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Carmona-Calero, E.M. et al.

Carmona-Calero, Perez-Gonzalez, Martinez-Peña Y Valenzuela, Gonzalez-Marrero, Perez-Garcia, Marrero-Gordillo, Ormazabal-Ramos, Castañeyra-Perdomo, Ferres-Torres,

Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats.

We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using anti-angiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment.[1]

References

Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats. Carmona-Calero, E.M., Perez-Gonzalez, H., Martinez-Peña Y Valenzuela, I., Gonzalez-Marrero, I., Perez-Garcia, C.G., Marrero-Gordillo, N., Ormazabal-Ramos, C., Castañeyra-Perdomo, A., Ferres-Torres, R. Histol. Histopathol. (2005) [Pubmed]

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