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MeSH Review

Subfornical Organ

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Disease relevance of Subfornical Organ


Psychiatry related information on Subfornical Organ


High impact information on Subfornical Organ


Chemical compound and disease context of Subfornical Organ


Biological context of Subfornical Organ


Anatomical context of Subfornical Organ


Associations of Subfornical Organ with chemical compounds

  • ICV carbachol (Carb), on the other hand, did not elicit drinking before 4 days, despite the fact that these dipsogens (Carb and Ang II) may both affect receptors in the subfornical organ [26].
  • The circumventricular organs, organum vasculosum lamina terminalis (OVLT) and subfornical organ (SFO), are potential sites that could detect increases in plasma lactate levels and activate the DMH [27].
  • ANF was significantly decreased in seven brain areas in SHR at both ages investigated; the most pronounced decreases were found in the subfornical organ, in the perifornical and periventricular hypothalamic nuclei, and in the medial preoptic nucleus [28].
  • In brain, ACE activity was markedly reduced 4 hours after lisinopril administration in the circumventricular organs, including the subfornical organ (16-22%) and organum vasculosum of the lamina terminalis (7%; p less than 0.05) [29].
  • Control injections of losartan into areas adjacent to the subfornical organ had no effect on the responses to hypertonic saline [30].

Gene context of Subfornical Organ


Analytical, diagnostic and therapeutic context of Subfornical Organ


  1. Subfornical organ. Does it protect against angiotensin II-induced hypertension in the rat? Bruner, C.A., Mangiapane, M.L., Fink, G.D. Circ. Res. (1985) [Pubmed]
  2. The angiotensin II pressor system of the rat forebrain. Hartle, D.K., Brody, M.J. Circ. Res. (1984) [Pubmed]
  3. Lesions of the subfornical organ block angiotensin-induced drinking in the dog. Thrasher, T.N., Simpson, J.B., Ramsay, D.J. Neuroendocrinology (1982) [Pubmed]
  4. Disruption of the blood-brain barrier during TNBS colitis. Natah, S.S., Mouihate, A., Pittman, Q.J., Sharkey, K.A. Neurogastroenterol. Motil. (2005) [Pubmed]
  5. CNS pathways mediating cardiovascular regulation of vasopressin. Renaud, L.P. Clin. Exp. Pharmacol. Physiol. (1996) [Pubmed]
  6. Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ. Nomura, M., Ueta, Y., Larsen, P.J., Hannibal, J., Serino, R., Kabashima, N., Shibuya, I., Yamashita, H. Endocrinology (1997) [Pubmed]
  7. Atriopeptin prevents angiotensin II-stimulated glucose utilization in the subfornical organ. Nermo-Lindquist, E., Kadekaro, M., Terrell, M.L., Nassar, J., Lekan, H., Freeman, S. Peptides (1990) [Pubmed]
  8. Systemic angiotensin II acts at the subfornical organ to suppress voluntary alcohol consumption. Grupp, L.A., Perlanski, E., Stewart, R.B. Pharmacol. Biochem. Behav. (1989) [Pubmed]
  9. Self-stimulation of the subfornical organ and lateral hypothalamus: differential effects of atropine and methysergide. Robertson, A., Kucharczyk, J., Mogenson, G.J. Pharmacol. Biochem. Behav. (1977) [Pubmed]
  10. Subfornical organ: a dipsogenic site of action of angiotensin II. Simpson, J.B., Routtenberg, A. Science (1978) [Pubmed]
  11. Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat. Sunn, N., Egli, M., Burazin, T.C., Burns, P., Colvill, L., Davern, P., Denton, D.A., Oldfield, B.J., Weisinger, R.S., Rauch, M., Schmid, H.A., McKinley, M.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  12. Angiotensin II receptors in paraventricular nucleus, subfornical organ, and pituitary gland of hypophysectomized, adrenalectomized, and vasopressin-deficient rats. Castrén, E., Saavedra, J.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  13. Rich ependymal investment of luliberin (LHRH) fibers revealed immunocytochemically in an image like that from Golgi stain. Burchanowski, B.J., Knigge, K.M., Sternberger, L.A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  14. Metabolic mapping of functional activity in rat brain and pituitary after water deprivation. Duncan, G.E., Oglesby, S.A., Greenwood, R.S., Meeker, R.B., Hayward, J.N., Stumpf, W.E. Neuroendocrinology (1989) [Pubmed]
  15. Effect of water deprivation and salt loading on atrial natriuretic peptide-stimulated guanylate cyclase activity in the rat subfornical organ. Israel, A., del Rosario Garrido, M., Barbella, Y., Becemberg, I. Neuroendocrinology (1989) [Pubmed]
  16. Polydipsia and abolition of angiotensin-induced drinking after transections of subfornical organ efferent projections in the rat. Eng, R., Miselis, R.R. Brain Res. (1981) [Pubmed]
  17. Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats. Carmona-Calero, E.M., Perez-Gonzalez, H., Martinez-Peña Y Valenzuela, I., Gonzalez-Marrero, I., Perez-Garcia, C.G., Marrero-Gordillo, N., Ormazabal-Ramos, C., Castañeyra-Perdomo, A., Ferres-Torres, R. Histol. Histopathol. (2005) [Pubmed]
  18. Decreased number and affinity of rat atrial natriuretic peptide (6-33) binding sites in the subfornical organ of spontaneously hypertensive rats. Saavedra, J.M., Israel, A., Kurihara, M., Fuchs, E. Circ. Res. (1986) [Pubmed]
  19. Role of the subfornical organ in the relaxin-induced prolongation of gestation in the rat. Summerlee, A.J., Wilson, B.C. Endocrinology (1994) [Pubmed]
  20. Noradrenaline release in the rat subfornical organ area to blood pressure changes. Tanaka, J., Hayashi, Y., Watai, T., Hori, K., Nomura, M. Exp. Neurol. (1998) [Pubmed]
  21. The subfornical organ and relaxin-induced inhibition of reflex milk ejection in lactating rats. Summerlee, A.J., O'Byrne, K.T., Jones, S.A., Eltringham, L. J. Endocrinol. (1987) [Pubmed]
  22. Ventricular obstruction: effect on drinking induced by intracranial injection of angiotensin. Buggy, J., Fisher, A.E., Hoffman, W.E., Johnson, A.L., Phillips, M.I. Science (1975) [Pubmed]
  23. Autoradiographic localization and characterization of atrial natriuretic peptide binding sites in the rat central nervous system and adrenal gland. Gibson, T.R., Wildey, G.M., Manaker, S., Glembotski, C.C. J. Neurosci. (1986) [Pubmed]
  24. Subfornical organ-median preoptic connections and drinking and pressor responses to angiotensin II. Lind, R.W., Johnson, A.K. J. Neurosci. (1982) [Pubmed]
  25. Increased brain transcription factor expression by angiotensin in genetic hypertension. Blume, A., Lebrun, C.J., Herdegen, T., Bravo, R., Linz, W., Möllenhoff, E., Unger, T. Hypertension (1997) [Pubmed]
  26. The arousal of ingestive behaviors by chemical injection into the brain of the suckling rat. Ellis, S., Axt, K., Epstein, A.N. J. Neurosci. (1984) [Pubmed]
  27. The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder. Shekhar, A., Keim, S.R. J. Neurosci. (1997) [Pubmed]
  28. Atrial natriuretic factor in specific brain areas of spontaneously hypertensive rats. Bahner, U., Geiger, H., Palkovits, M., Heidland, A. Hypertension (1988) [Pubmed]
  29. Inhibition of tissue angiotensin converting enzyme. Quantitation by autoradiography. Sakaguchi, K., Chai, S.Y., Jackson, B., Johnston, C.I., Mendelsohn, F.A. Hypertension (1988) [Pubmed]
  30. Osmotically induced natriuresis and blood pressure response involves angiotensin AT1 receptors in the subfornical organ. Rohmeiss, P., Beyer, C., Hocher, B., Qadri, F., Gretz, N., Strauch, M., Unger, T. J. Hypertens. (1995) [Pubmed]
  31. Expression of basic fibroblast growth factor and its receptor in the rat subfornical organ. Frautschy, S.A., Gonzalez, A.M., Martinez Murillo, R., Carceller, F., Cuevas, P., Baird, A. Neuroendocrinology (1991) [Pubmed]
  32. Water deprivation upregulates ANG II AT1 binding and mRNA in rat subfornical organ and anterior pituitary. Sanvitto, G.L., Jöhren, O., Häuser, W., Saavedra, J.M. Am. J. Physiol. (1997) [Pubmed]
  33. Receptor pharmacology. Young, A. Adv. Pharmacol. (2005) [Pubmed]
  34. TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ. Son, Y.J., Hur, M.K., Ryu, B.J., Park, S.K., Damante, G., D'Elia, A.V., Costa, M.E., Ojeda, S.R., Lee, B.J. J. Biol. Chem. (2003) [Pubmed]
  35. Astrocytes in sensory circumventricular organs of the rat brain express functional binding sites for endothelin. Gebke, E., Müller, A.R., Pehl, U., Gerstberger, R. Neuroscience (2000) [Pubmed]
  36. Estrogen decreases the responsiveness of subfornical organ neurons to angiotensinergic neural inputs from the lateral hypothalamic area in the female rat. Tanaka, J., Miyakubo, H., Nomura, M. Exp. Neurol. (2001) [Pubmed]
  37. Angiotensin II-induced calcium signalling in neurons and astrocytes of rat circumventricular organs. Gebke, E., Müller, A.R., Jurzak, M., Gerstberger, R. Neuroscience (1998) [Pubmed]
  38. Differential increase in Fos immunoreactivity in hypothalamic and septal nuclei by arginine8-vasopressin and desglycinamide9-arginine8-vasopressin. Lança, A.J., Wu, P.H., Jung, B., Liu, J.F., Ng, V., Kalant, H. Neuroscience (1999) [Pubmed]
  39. Luliberin and somatostatin fiber-terminals in the subfornical organ of the rat. Krisch, B., Leonhardt, H. Cell Tissue Res. (1980) [Pubmed]
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