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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells.

In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T<alpha-T3<gamma-T<gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.[1]

References

  1. Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. Conte, C., Floridi, A., Aisa, C., Piroddi, M., Floridi, A., Galli, F. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
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