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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations.

Vigabatrin and (S)-4-allenylGABA (MDL 72483), two anticonvulsant GABA-T inhibitors, partially antagonize phencyclidine (PCP)-induced hyperactivity in mice at doses that do not affect spontaneous motor activity. The PCP antagonism is related to whole-brain GABA concentrations. The results indicate the potential use of GABA-T inhibitors in the therapy of PCP intoxications and perhaps also in the treatment of certain forms of endogenous psychoses.[1]

References

  1. Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations. Seiler, N., Grauffel, C. Pharmacol. Biochem. Behav. (1992) [Pubmed]
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