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Gene Review

Abat  -  4-aminobutyrate aminotransferase

Mus musculus

Synonyms: (S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate aminotransferase, mitochondrial, 9630038C02Rik, AI255750, ENSMUSG00000051226, ...
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Disease relevance of Abat


Psychiatry related information on Abat


High impact information on Abat


Biological context of Abat


Anatomical context of Abat


Associations of Abat with chemical compounds


Other interactions of Abat


Analytical, diagnostic and therapeutic context of Abat

  • Induction of analgesia and morphine potentiation by irreversible inhibitors of GABA-transaminase [proceedings] [27].
  • Following chronic oral administration via drinking water containing the drugs, immobility was significantly reduced at days 5 and 10 in all of the GABA-T inhibitors examined [28].
  • When the aminotransferases were tested with the antibody against the purified 4-aminobutyrate aminotransferase from brain, no difference could be detected among brain, spinal cord, and kidney preparations as judged from the results of immunodiffusion, inhibition of enzyme activity by antibody, and microcomplement fixation [29].
  • Inhibition of GABA-T produced a significant increase of polyamine turnover in brain, in agreement with the known induction of ornithine decarboxylase activity after treatment with inhibitors of GABA-T [30].
  • The elicited syndrome can be antagonized dose-dependently by GABA-agonists, by GABA-transaminase inhibitors, by GABA neuronal uptake inhibitors, and by benzodiazepines stereospecifically after appropriate premedication times and routes [31].


  1. A bioluminescent gamma-aminobutyrate assay for monitoring its release from inhibitory nerve endings. Israël, M., Lesbats, B. J. Neurochem. (1996) [Pubmed]
  2. Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations. Seiler, N., Grauffel, C. Pharmacol. Biochem. Behav. (1992) [Pubmed]
  3. Sequential neuropathology of dogs treated with vigabatrin, a GABA-transaminase inhibitor. Yarrington, J.T., Gibson, J.P., Dillberger, J.E., Hurst, G., Lippert, B., Sussman, N.M., Heydorn, W.E., Marler, R.J. Toxicologic pathology. (1993) [Pubmed]
  4. Effects of ammonia on monoamine oxidase and enzymes of GABA metabolism in mouse brain. Sadasivudu, B., Radha Krishna Murthy, C. Arch. Int. Physiol. Biochim. (1978) [Pubmed]
  5. GABAergic modulation of memory with regard to passive avoidance and conditioned suppression task in mice. Nabeshima, T., Noda, Y., Kameyama, T. Psychopharmacology (Berl.) (1988) [Pubmed]
  6. Gamma-aminobutyric acid controls the mouse hypothalamic-pituitary-testicular response to the presence of female. Naumenko, E.V., Serova, L.I. Pharmacol. Biochem. Behav. (1991) [Pubmed]
  7. Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro. Towers, S.K., Gloveli, T., Traub, R.D., Driver, J.E., Engel, D., Fradley, R., Rosahl, T.W., Maubach, K., Buhl, E.H., Whittington, M.A. J. Physiol. (Lond.) (2004) [Pubmed]
  8. Alteration of amino acid metabolism in epileptogenic mice by elevation of brain pyridoxal phosphate. Norris, D.K., Murphy, R.A., Chung, S.H. J. Neurochem. (1985) [Pubmed]
  9. Possible involvement of humoral regulation in the effects of elevated cerebral 4-aminobutyric acid levels on the polyamine metabolism in brain. Lapinjoki, S.P., Pulkka, A.E., Laitinen, S.I., Pajunen, A.E. J. Neurochem. (1983) [Pubmed]
  10. Combined effects of a metabolic inhibitor (gabaculine) and an uptake inhibitor (ketamine) on the gamma-aminobutyrate system in mouse brain. Wood, J.D., Geddes, J.W., Tsui, S.K., Kurylo, E. J. Neurochem. (1982) [Pubmed]
  11. Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice. Löscher, W. Biochem. Pharmacol. (1982) [Pubmed]
  12. Comparative study of the inhibition of GABA aminotransferase by different anticonvulsant drugs. Löscher, W. Archives internationales de pharmacodynamie et de thérapie. (1980) [Pubmed]
  13. Inhibitory effects of the essential oil from SuHeXiang Wan on the central nervous system after inhalation. Koo, B.S., Lee, S.I., Ha, J.H., Lee, D.U. Biol. Pharm. Bull. (2004) [Pubmed]
  14. Interactions of di-n-propylacetate, gabaculine, and aminooxyacetic acid: anticonvulsant activity and the gamma-aminobutyrate system. Wood, J.D., Kurylo, E., Tsui, S.K. J. Neurochem. (1981) [Pubmed]
  15. The effects of sodium valproate on gamma-aminobutyrate metabolism and behaviour in naive and ethanolamine-O-sulphate pretreated rats and mice. Phillips, N.I., Fowler, L.J. Biochem. Pharmacol. (1982) [Pubmed]
  16. Development of homospecific activity of GABA-transaminase in the mouse cerebral cortex and cerebellum and in neurons cultured from these brain areas. Schousboe, I., Larsson, O.M., Schousboe, A. Int. J. Dev. Neurosci. (1989) [Pubmed]
  17. Effects of selective dopamine D1 and D2 receptor agonists on the rate of GABA synthesis in mouse brain. Steulet, A.F., Bernasconi, R., Leonhardt, T., Martin, P., Grünenwald, C., Bischoff, S., Heinrich, M., Bandelier, V., Maître, L. Eur. J. Pharmacol. (1990) [Pubmed]
  18. Kinetic characterization of GABA-transaminase from cultured neurons and astrocytes. Larsson, O.M., Schousboe, A. Neurochem. Res. (1990) [Pubmed]
  19. Effect of inhibitors of GABA aminotransferase on the metabolism of GABA in brain tissue and synaptosomal fractions. Löscher, W. J. Neurochem. (1981) [Pubmed]
  20. The use of inhibitors of GABA-transaminase for the determination of GABA turnover in mouse brain regions: an evaluation of aminooxyacetic acid and gabaculine. Bernasconi, R., Maitre, L., Martin, P., Raschdorf, F. J. Neurochem. (1982) [Pubmed]
  21. omega-Fluoromethyl analogues of omega-amino acids as irreversible inhibitors of 4-aminobutyrate:2-oxoglutarate aminotransferase. Bey, P., Jung, M.J., Gerhart, F., Schirlin, D., Van Dorsselaer, V., Casara, P. J. Neurochem. (1981) [Pubmed]
  22. Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters. Staines, W.A., Morassutti, D.J., Reuhl, K.R., Ally, A.I., McBurney, M.W. Neuroscience (1994) [Pubmed]
  23. Effects of alcohol and acetaldehyde on metabolism and function of neurotransmitter systems in cerebral cortical neurons in primary culture. Kuriyama, K., Ohkuma, S., Tomono, S., Hirouchi, M. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. (1987) [Pubmed]
  24. GABAergic influences on plus-maze behaviour in mice. Dalvi, A., Rodgers, R.J. Psychopharmacology (Berl.) (1996) [Pubmed]
  25. Antiepileptic action induced by a combination of vigabatrin and tiagabine. Fueta, Y., Kunugita, N., Schwarz, W. Neuroscience (2005) [Pubmed]
  26. GABA metabolism in Venezuelan equine encephalomyelitis virus infection. Bonilla, E., Ryder, E., Ryder, S. Neurochem. Res. (1980) [Pubmed]
  27. Induction of analgesia and morphine potentiation by irreversible inhibitors of GABA-transaminase [proceedings]. Buckett, W.R. Br. J. Pharmacol. (1980) [Pubmed]
  28. Potential antidepressant properties of subchronic GABA transaminase inhibitors in the forced swimming test in mice. Semba, J., Kuroda, Y., Takahashi, R. Neuropsychobiology (1989) [Pubmed]
  29. Distribution and tissue specificity of 4-aminobutyrate-2-oxoglutarate aminotransferase. Wu, J.Y., Moss, L.G., Chude, O. Neurochem. Res. (1978) [Pubmed]
  30. Polyamine reutilization and turnover in brain. Seiler, N., Bolkenius, F.N. Neurochem. Res. (1985) [Pubmed]
  31. Intravenous bicuculline test in mice: characterization with GABAergic drugs. Buckett, W.R. Journal of pharmacological methods. (1981) [Pubmed]
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