Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Miller-Lotan, R. et al.

Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus.

BACKGROUND: The human haptoglobin (Hp) gene is polymorphic with two functional classes of alleles, denoted 1 and 2. We have demonstrated in three longitudinal studies and several cross-sectional studies that the Hp genotype is an independent risk factor for diabetic vascular disease. These studies have presented a compelling argument that diabetic individuals homozygous for the Hp 1 allele are at decreased risk of vascular complications as compared to diabetic individuals with the Hp 2 allele. METHODS: The naturally occurring (wild type) mouse Hp is a class 1 Hp allele. We examined renal hypertrophy in wild-type mice, Hp knockout mice (Hp 0), and in mice with the Hp 2 allele (Hp 2) with and without diabetes. RESULTS: In the absence of diabetes, we found that renal hypertrophy was significantly increased in Hp 0 mice and that this could be prevented with vitamin E. There was no difference between wild type and Hp 2 mice with regard to renal hypertrophy in the absence of diabetes. However, in the presence of diabetes, Hp 2 mice demonstrated a significant increase in renal hypertrophy as compared to wild-type mice. CONCLUSIONS: These results support a direct linkage between diabetic vascular disease and the Hp genotype. These Hp-modified mice may serve as a platform on which to test a variety of pharmacological agents in order to decrease diabetic vascular disease.[1]

References

Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus. Miller-Lotan, R., Herskowitz, Y., Kalet-Litman, S., Nakhoul, F., Aronson, D., Zoabi, R., Asaf, R., Ben-Izhak, O., Sabo, E., Lim, S.K., Baumann, H., Berger, F.G., Levy, A.P. Diabetes Metab. Res. Rev. (2005) [Pubmed]

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