- I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. Ruocco, M.G., Maeda, S., Park, J.M., Lawrence, T., Hsu, L.C., Cao, Y., Schett, G., Wagner, E.F., Karin, M. J. Exp. Med. (2005)