Gene Review:
Ikbkb - inhibitor of kappaB kinase beta
Mus musculus
Synonyms:
AI132552, I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-2, IKK-B, ...
- TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Pasparakis, M., Courtois, G., Hafner, M., Schmidt-Supprian, M., Nenci, A., Toksoy, A., Krampert, M., Goebeler, M., Gillitzer, R., Israel, A., Krieg, T., Rajewsky, K., Haase, I. Nature (2002)
- Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Luedde, T., Assmus, U., Wüstefeld, T., Meyer zu Vilsendorf, A., Roskams, T., Schmidt-Supprian, M., Rajewsky, K., Brenner, D.A., Manns, M.P., Pasparakis, M., Trautwein, C. J. Clin. Invest. (2005)
- The IKK-2/Ikappa Balpha /NF-kappa B pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in Ikappa Balpha -deficient mice. Huber, M.A., Denk, A., Peter, R.U., Weber, L., Kraut, N., Wirth, T. J. Biol. Chem. (2002)
- IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cai, D., Frantz, J.D., Tawa, N.E., Melendez, P.A., Oh, B.C., Lidov, H.G., Hasselgren, P.O., Frontera, W.R., Lee, J., Glass, D.J., Shoelson, S.E. Cell (2004)
- IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Maeda, S., Kamata, H., Luo, J.L., Leffert, H., Karin, M. Cell (2005)
- Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., De Lorenzi, R., Krone, W., Rajewsky, K., Brüning, J.C. J. Clin. Invest. (2004)
- Binding of manumycin A inhibits IkappaB kinase beta activity. Bernier, M., Kwon, Y.K., Pandey, S.K., Zhu, T.N., Zhao, R.J., Maciuk, A., He, H.J., Decabo, R., Kole, S. J. Biol. Chem. (2006)
- Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents. Murata, T., Shimada, M., Sakakibara, S., Yoshino, T., Masuda, T., Shintani, T., Sato, H., Koriyama, Y., Fukushima, K., Nunami, N., Yamauchi, M., Fuchikami, K., Komura, H., Watanabe, A., Ziegelbauer, K.B., Bacon, K.B., Lowinger, T.B. Bioorg. Med. Chem. Lett. (2004)
- Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.F., Verma, I.M. Science (1999)
- The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. Li, Z.W., Chu, W., Hu, Y., Delhase, M., Deerinck, T., Ellisman, M., Johnson, R., Karin, M. J. Exp. Med. (1999)
- IKK beta is required for peripheral B cell survival and proliferation. Li, Z.W., Omori, S.A., Labuda, T., Karin, M., Rickert, R.C. J. Immunol. (2003)
- Mature T cells depend on signaling through the IKK complex. Schmidt-Supprian, M., Courtois, G., Tian, J., Coyle, A.J., Israël, A., Rajewsky, K., Pasparakis, M. Immunity (2003)
- Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Tanaka, M., Fuentes, M.E., Yamaguchi, K., Durnin, M.H., Dalrymple, S.A., Hardy, K.L., Goeddel, D.V. Immunity (1999)
- I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. Ruocco, M.G., Maeda, S., Park, J.M., Lawrence, T., Hsu, L.C., Cao, Y., Schett, G., Wagner, E.F., Karin, M. J. Exp. Med. (2005)
- Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H., Okumura, K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Lang, V., Janzen, J., Fischer, G.Z., Soneji, Y., Beinke, S., Salmeron, A., Allen, H., Hay, R.T., Ben-Neriah, Y., Ley, S.C. Mol. Cell. Biol. (2003)
- Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Cai, D., Yuan, M., Frantz, D.F., Melendez, P.A., Hansen, L., Lee, J., Shoelson, S.E. Nat. Med. (2005)
- IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Egan, L.J., Eckmann, L., Greten, F.R., Chae, S., Li, Z.W., Myhre, G.M., Robine, S., Karin, M., Kagnoff, M.F. Proc. Natl. Acad. Sci. U.S.A. (2004)
- IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Maeda, S., Chang, L., Li, Z.W., Luo, J.L., Leffert, H., Karin, M. Immunity (2003)
- Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells. Chen, T.H., Kao, Y.C., Chen, B.C., Chen, C.H., Chan, P., Lee, H.M. Eur. J. Pharmacol. (2006)
- Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Li, Q., Lu, Q., Bottero, V., Estepa, G., Morrison, L., Mercurio, F., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity. Jeong, S.J., Pise-Masison, C.A., Radonovich, M.F., Park, H.U., Brady, J.N. J. Biol. Chem. (2005)
- A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. Kamon, J., Yamauchi, T., Muto, S., Takekawa, S., Ito, Y., Hada, Y., Ogawa, W., Itai, A., Kasuga, M., Tobe, K., Kadowaki, T. Biochem. Biophys. Res. Commun. (2004)
- Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation. Otero, J.E., Dai, S., Foglia, D., Alhawagri, M., Vacher, J., Pasparakis, M., Abu-Amer, Y. J. Biol. Chem. (2008)
- Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Sakurai, T., Maeda, S., Chang, L., Karin, M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Ikappab kinase-beta (ikkbeta) modulation of epithelial sodium channel activity. Lebowitz, J., Edinger, R.S., An, B., Perry, C.J., Onate, S., Kleyman, T.R., Johnson, J.P. J. Biol. Chem. (2004)