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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T-bet is required for optimal proinflammatory CD4+ T-cell trafficking.

Inflammatory responses are controlled by T helper 1 ( Th1) lymphocytes. An important function of this polarity is the ability of T cells to traffick appropriately in vivo. This differential trafficking is dependent upon the binding of P-selectin glycoprotein ligand-1 to P- and E-selectin on inflamed endothelium as well as the expression of specific chemokine receptors. Here we show that in the absence of T-box expressed in T cells (T-bet), selective migration of T cells in vivo is completely abrogated and that T-bet regulates the binding of CD4(+) T cells to P-selectin. T-bet is also required for the expression of the chemokine receptor CXCR3. Thus, T-bet controls Th1-cell migration to inflammatory sites, which has fundamental consequences for the control of immunologic disease.[1]

References

  1. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Lord, G.M., Rao, R.M., Choe, H., Sullivan, B.M., Lichtman, A.H., Luscinskas, F.W., Glimcher, L.H. Blood (2005) [Pubmed]
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