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Gene Review

Selp  -  selectin, platelet

Mus musculus

Synonyms: CD62 antigen-like family member P, CD62P, GMP-140, Granule membrane protein 140, Grmp, ...
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Disease relevance of Selp


Psychiatry related information on Selp


High impact information on Selp


Chemical compound and disease context of Selp


Biological context of Selp


Anatomical context of Selp


Associations of Selp with chemical compounds


Physical interactions of Selp

  • These studies confirmed that core-2 O-glycans attached to Thr-57 play a critical role in supporting L- and P-selectin-dependent rolling and revealed that additional binding sites support >75% of E-selectin-mediated rolling [26].
  • P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin controls early leukocyte rolling during inflammation [27].
  • Treatment of WEHI-3B cells with trypsin or neuraminidase abolished their ability to interact with P-selectin [28].
  • Both P-selectin expression and fibrinogen binding in response to CRP were also decreased to a similar extent in p85alpha-/- platelets [29].
  • Treatment of HSA with OSGE significantly reduced binding of both P-selectin and I [30].

Enzymatic interactions of Selp

  • Fuc-TVII deficiency also deletes expression of E- and P-selectin ligands by Th1 and T cytotoxic 1 (Tc1) lymphocytes, annuls T cell trafficking to inflamed cutaneous sites in vivo, and thereby controls an essential component of the efferent phase of the cutaneous immune response [31].

Co-localisations of Selp


Regulatory relationships of Selp


Other interactions of Selp

  • In contrast, an mAb (KAT-1) blocking ICAM-1 binding to leukocyte function-associated antigen 1 did not block residual rolling in P-selectin-deficient mice [33].
  • Recently, our laboratory showed that platelets, like leukocytes, roll on activated endothelium expressing P-selectin, thus suggesting a role for P-selectin in hemostasis (Frenette et at, Proc Natl Acad Sci USA 92:7450, 1995) [37].
  • Significant levels of eotaxin were detected in response to IL-13/IL-4 in both tissues in P-selectin-deficient animals [38].
  • In conclusion, the regulatory role of P-selectin in leukocyte transmigration elicited by IL-13 appears to be tissue-specific, a phenomenon that is independent of the ability of the cytokine to stimulate eotaxin generation [38].
  • MMP-9 blockade is associated with an attenuation of TNF-alpha release and endothelial CD62P expression, weakly protects from early microvascular/hepatocellular I/R damage, but improves postischemic survival [39].

Analytical, diagnostic and therapeutic context of Selp


  1. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Hrachovinová, I., Cambien, B., Hafezi-Moghadam, A., Kappelmayer, J., Camphausen, R.T., Widom, A., Xia, L., Kazazian, H.H., Schaub, R.G., McEver, R.P., Wagner, D.D. Nat. Med. (2003) [Pubmed]
  2. Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent. Symon, F.A., Walsh, G.M., Watson, S.R., Wardlaw, A.J. J. Exp. Med. (1994) [Pubmed]
  3. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Borsig, L., Wong, R., Hynes, R.O., Varki, N.M., Varki, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Iwaki, T., Sandoval-Cooper, M.J., Brechmann, M., Ploplis, V.A., Castellino, F.J. Blood (2006) [Pubmed]
  5. Complement-dependent P-selectin expression and injury following ischemic stroke. Atkinson, C., Zhu, H., Qiao, F., Varela, J.C., Yu, J., Song, H., Kindy, M.S., Tomlinson, S. J. Immunol. (2006) [Pubmed]
  6. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Fernekorn, U., Butcher, E.C., Behrends, J., Hartz, S., Kruse, A. Eur. J. Immunol. (2004) [Pubmed]
  7. Mechanisms that regulate the function of the selectins and their ligands. Vestweber, D., Blanks, J.E. Physiol. Rev. (1999) [Pubmed]
  8. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Malý, P., Thall, A., Petryniak, B., Rogers, C.E., Smith, P.L., Marks, R.M., Kelly, R.J., Gersten, K.M., Cheng, G., Saunders, T.L., Camper, S.A., Camphausen, R.T., Sullivan, F.X., Isogai, Y., Hindsgaul, O., von Andrian, U.H., Lowe, J.B. Cell (1996) [Pubmed]
  9. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Mayadas, T.N., Johnson, R.C., Rayburn, H., Hynes, R.O., Wagner, D.D. Cell (1993) [Pubmed]
  10. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Läubli, H., Stevenson, J.L., Varki, A., Varki, N.M., Borsig, L. Cancer Res. (2006) [Pubmed]
  11. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. Yanaba, K., Kaburagi, Y., Takehara, K., Steeber, D.A., Tedder, T.F., Sato, S. Am. J. Pathol. (2003) [Pubmed]
  12. E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. Horikawa, M., Fujimoto, M., Hasegawa, M., Matsushita, T., Hamaguchi, Y., Kawasuji, A., Matsushita, Y., Fujita, T., Ogawa, F., Takehara, K., Steeber, D.A., Sato, S. Am. J. Pathol. (2006) [Pubmed]
  13. Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice. Broide, D.H., Humber, D., Sullivan, S., Sriramarao, P. Blood (1998) [Pubmed]
  14. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E-selectin-mediated neutrophil rolling and migration. Yang, J., Hirata, T., Croce, K., Merrill-Skoloff, G., Tchernychev, B., Williams, E., Flaumenhaft, R., Furie, B.C., Furie, B. J. Exp. Med. (1999) [Pubmed]
  15. Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells. Yao, L., Pan, J., Setiadi, H., Patel, K.D., McEver, R.P. J. Exp. Med. (1996) [Pubmed]
  16. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. Collins, R.G., Velji, R., Guevara, N.V., Hicks, M.J., Chan, L., Beaudet, A.L. J. Exp. Med. (2000) [Pubmed]
  17. Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. Hahne, M., Jäger, U., Isenmann, S., Hallmann, R., Vestweber, D. J. Cell Biol. (1993) [Pubmed]
  18. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Barkalow, F.J., Goodman, M.J., Gerritsen, M.E., Mayadas, T.N. Blood (1996) [Pubmed]
  19. Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditions. Fernekorn, U., Butcher, E.C., Behrends, J., Karsten, C.M., Röbke, A., Schulze, T.J., Kirchner, H., Kruse, A. Biol. Reprod. (2007) [Pubmed]
  20. Genetic control of the immune response in pathogenesis. Baker, P.J. J. Periodontol. (2005) [Pubmed]
  21. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Huo, Y., Schober, A., Forlow, S.B., Smith, D.F., Hyman, M.C., Jung, S., Littman, D.R., Weber, C., Ley, K. Nat. Med. (2003) [Pubmed]
  22. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. Xia, L., Sperandio, M., Yago, T., McDaniel, J.M., Cummings, R.D., Pearson-White, S., Ley, K., McEver, R.P. J. Clin. Invest. (2002) [Pubmed]
  23. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo. Norman, K.E., Katopodis, A.G., Thoma, G., Kolbinger, F., Hicks, A.E., Cotter, M.J., Pockley, A.G., Hellewell, P.G. Blood (2000) [Pubmed]
  24. Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. Carrithers, M.D., Visintin, I., Kang, S.J., Janeway, C.A. Brain (2000) [Pubmed]
  25. Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells. Pan, J., Xia, L., McEver, R.P. J. Biol. Chem. (1998) [Pubmed]
  26. Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. Martinez, M., Joffraud, M., Giraud, S., Baïsse, B., Bernimoulin, M.P., Schapira, M., Spertini, O. J. Biol. Chem. (2005) [Pubmed]
  27. L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited. Ridger, V.C., Hellewell, P.G., Norman, K.E. Am. J. Pathol. (2005) [Pubmed]
  28. Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor. Yang, J., Galipeau, J., Kozak, C.A., Furie, B.C., Furie, B. Blood (1996) [Pubmed]
  29. Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation. Watanabe, N., Nakajima, H., Suzuki, H., Oda, A., Matsubara, Y., Moroi, M., Terauchi, Y., Kadowaki, T., Suzuki, H., Koyasu, S., Ikeda, Y., Handa, M. Blood (2003) [Pubmed]
  30. Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1. Sammar, M., Aigner, S., Altevogt, P. Biochim. Biophys. Acta (1997) [Pubmed]
  31. Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. Smithson, G., Rogers, C.E., Smith, P.L., Scheidegger, E.P., Petryniak, B., Myers, J.T., Kim, D.S., Homeister, J.W., Lowe, J.B. J. Exp. Med. (2001) [Pubmed]
  32. Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice. Denis, C.V., André, P., Saffaripour, S., Wagner, D.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  33. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. Kunkel, E.J., Jung, U., Bullard, D.C., Norman, K.E., Wolitzky, B.A., Vestweber, D., Beaudet, A.L., Ley, K. J. Exp. Med. (1996) [Pubmed]
  34. Peritoneal macrophages express both P-selectin and PSGL-1. Tchernychev, B., Furie, B., Furie, B.C. J. Cell Biol. (2003) [Pubmed]
  35. Enhanced expression of P-selectin (CD62P) by endothelial cells seeded onto synthetic arterial prostheses (PET, Dacron) is correlated with leukocyte interactions. Guidollet, J., Chignier, E., Pillot, R., Gayet, O., MacGregor, J., Louisot, P. J. Biomed. Mater. Res. (1999) [Pubmed]
  36. E- and P-selectins are essential for the development of cockroach allergen-induced airway responses. Lukacs, N.W., John, A., Berlin, A., Bullard, D.C., Knibbs, R., Stoolman, L.M. J. Immunol. (2002) [Pubmed]
  37. Defects in hemostasis in P-selectin-deficient mice. Subramaniam, M., Frenette, P.S., Saffaripour, S., Johnson, R.C., Hynes, R.O., Wagner, D.D. Blood (1996) [Pubmed]
  38. P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. Larbi, K.Y., Dangerfield, J.P., Culley, F.J., Marshall, D., Haskard, D.O., Jose, P.J., Williams, T.J., Nourshargh, S. J. Leukoc. Biol. (2003) [Pubmed]
  39. Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver. Khandoga, A., Kessler, J.S., Hanschen, M., Khandoga, A.G., Burggraf, D., Reichel, C., Hamann, G.F., Enders, G., Krombach, F. J. Leukoc. Biol. (2006) [Pubmed]
  40. Platelet-endothelial interactions in inflamed mesenteric venules. Frenette, P.S., Moyna, C., Hartwell, D.W., Lowe, J.B., Hynes, R.O., Wagner, D.D. Blood (1998) [Pubmed]
  41. Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow. Woltmann, G., McNulty, C.A., Dewson, G., Symon, F.A., Wardlaw, A.J. Blood (2000) [Pubmed]
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