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Mühling, J. et al.

Mühling, Nickolaus, Halabi, Fuchs, Krüll, Engel, Wolff, Matejec, Langefeld, Welters, Menges, Dehne, Sablotzki, Hempelmann,

Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine.

The objective of this study was to determine the dose as well as duration of exposure-dependent effects of L-alanyl-L-glutamine, arginine or taurine on polymorphonuclear neutrophil (PMN) free alpha-keto acid profiles and, in a parallel study, on PMN immune functions. Exogenous L-alanyl-L-glutamine significantly increased PMN alpha-ketoglutarate, pyruvate PMN superoxide anion (O(2) (-)) generation, hydrogen peroxide (H(2)O(2)) formation and released myeloperoxidase ( MPO) activity. Arginine also led to significant increases in alpha-ketoglutarate, pyruvate, MPO release and H(2)O(2) generation. Formation of O(2) (-) on the other hand was decreased by arginine. Incubation with taurine resulted in lower intracellular pyruvate and alpha-ketobutyrate levels, decreased O(2) (-) and H(2)O(2) formation and a concomitant significantly increased MPO activity. We therefore believe that considerable changes in PMN free-alpha-keto-acid profiles, induced for example by L-alanyl-L-glutamine, arginine or taurine, may be one of the determinants in cell nutrition that considerably modulates the immunological competence of PMN.[1]

References

Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine. Mühling, J., Nickolaus, K.A., Halabi, M., Fuchs, M., Krüll, M., Engel, J., Wolff, M., Matejec, R., Langefeld, T.W., Welters, I.D., Menges, T., Dehne, M.G., Sablotzki, A., Hempelmann, G. Amino Acids (2005) [Pubmed]

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