The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Immunocompetence


Psychiatry related information on Immunocompetence


High impact information on Immunocompetence


Chemical compound and disease context of Immunocompetence


Biological context of Immunocompetence


Anatomical context of Immunocompetence


Associations of Immunocompetence with chemical compounds


Gene context of Immunocompetence

  • Because reduced expression of CD28 in T cells compromises immunocompetence, we examined whether CD28 expression is reduced in patients with RA in vivo and whether the reduction is related to TNFalpha [31].
  • Stimulation with IL-2 alone partially restored the immunocompetence of EALs to kill the tumor targets [32].
  • In conclusion, our experimental system is suitable for the investigation of chemokine and cytokine production by the human peritoneum, with the aim of assessing aspects of local immunocompetence [33].
  • In immune-compromised dwarf mice, prolactin restores immunocompetence [34].
  • We postulate that the inescapable lethality of the motheaten defect is due to the lack of immunocompetence during the critical developmental period before adulthood and perhaps to an autoaggressive component as well [35].

Analytical, diagnostic and therapeutic context of Immunocompetence


  1. Survival in Hodgkin's disease: the role of immunocompetence and other major risk factors. Faguet, G.B., Davis, H.C. Blood (1982) [Pubmed]
  2. Effect of hyperthermia on the immune response of normal rabbits. Shah, S.A., Dickson, J.A. Cancer Res. (1978) [Pubmed]
  3. Effects of vitamin B6 deficiency on thymic epithelial cells and T lymphocyte differentiation. Willis-Carr, J.I., St Pierre, R.L. J. Immunol. (1978) [Pubmed]
  4. Nutrients and their role in host resistance to infection. Field, C.J., Johnson, I.R., Schley, P.D. J. Leukoc. Biol. (2002) [Pubmed]
  5. Indomethacin enhancement of immunocompetence in melanoma patients. Tilden, A.B., Balch, C.M. Surgery (1981) [Pubmed]
  6. Cell-mediated immune response in MDMA users after repeated dose administration: studies in controlled versus noncontrolled settings. Pacifici, R., Zuccaro, P., Farré, M., Pichini, S., Di Carlo, S., Roset, P.N., Palmi, I., Ortuño, J., Menoyo, E., Segura, J., de la Torre, R. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  7. Immunity costs and behavioural modulation in male laboratory mice (Mus musculus) exposed to the odours of females. Barnard, C.J., Behnke, J.M., Gage, A.R., Brown, H., Smithurst, P.R. Physiol. Behav. (1997) [Pubmed]
  8. Effects of sexual dimorphism on facial attractiveness. Perrett, D.I., Lee, K.J., Penton-Voak, I., Rowland, D., Yoshikawa, S., Burt, D.M., Henzi, S.P., Castles, D.L., Akamatsu, S. Nature (1998) [Pubmed]
  9. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. Vazeux, R., Hoffman, P.A., Tomita, J.K., Dickinson, E.S., Jasman, R.L., St John, T., Gallatin, W.M. Nature (1992) [Pubmed]
  10. 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: possible mechanisms. Holsapple, M.P., Morris, D.L., Wood, S.C., Snyder, N.K. Annu. Rev. Pharmacol. Toxicol. (1991) [Pubmed]
  11. Single-nutrient effects on immunologic functions. Report of a workshop sponsored by the Department of Food and Nutrition and its nutrition advisory group of the American Medical Association. Beisel, W.R., Edelman, R., Nauss, K., Suskind, R.M. JAMA (1981) [Pubmed]
  12. A transforming growth factor beta 2 (TGF-beta 2)-like immunosuppressive factor in amniotic fluid and localization of TGF-beta 2 mRNA in the pregnant uterus. Altman, D.J., Schneider, S.L., Thompson, D.A., Cheng, H.L., Tomasi, T.B. J. Exp. Med. (1990) [Pubmed]
  13. THF-gamma 2, a thymic hormone, increases immunocompetence and survival in 5-fluorouracil-treated mice bearing MOPC-315 plasmacytoma. Ophir, R., Pecht, M., Halperin, D., Rashid, G., Burstein, Y., Ben-Efraim, S., Trainin, N. Cancer Immunol. Immunother. (1989) [Pubmed]
  14. Golan memorial lecture. Nutritional regulation of immunity and infection: from epidemiology to phenomenology to clinical practice. Chandra, R.K. J. Pediatr. Gastroenterol. Nutr. (1986) [Pubmed]
  15. Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion. Valenti, G. J. Endocrinol. Invest. (2002) [Pubmed]
  16. Chemoimmunotherapy of disseminated malignant melanoma with DTIC-BCG, transfer factor + melphalan. Schwarz, M.A., Gutterman, J.U., Burgess, M.A., Heilbrun, L.K., Murphy, W.K., Bodey, G.P., Stone, E., Turner-Chism, V., Hersh, E.M. Cancer (1980) [Pubmed]
  17. Role of chloramphenicol reduction products in aplastic anemia. Pazdernik, T.L., Corbett, M.D. Pharmacology (1980) [Pubmed]
  18. Prolactin as a modulator of lymphocyte responsiveness provides a possible mechanism of action for cyclosporine. Hiestand, P.C., Mekler, P., Nordmann, R., Grieder, A., Permmongkol, C. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  19. The effects of bleomycin on immunocompetence in man. Lehane, D.E., Hurd, E., Lane, M. Cancer Res. (1975) [Pubmed]
  20. Generation of stable cellular phenotypes in a human malignant cell line conditioned by alterations in the cellular microenvironment. Honsik, C.J., Diamant, M., Olsson, L. Cancer Res. (1986) [Pubmed]
  21. The effects of hormones on sex differences in infection: from genes to behavior. Klein, S.L. Neuroscience and biobehavioral reviews. (2000) [Pubmed]
  22. Acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction. Soderberg, L.S., Flick, J.T., Barnett,, J.B. Exp. Hematol. (1996) [Pubmed]
  23. Effect of iodoacetate on the bone marrow immunocompetence of AKR mice. Rheins, M.S., Filppi, J.A., Moore, V.S. Cancer Res. (1975) [Pubmed]
  24. Properties of a herpesvirus-transformed hamster cell line: immunogenicity of sublines of high and low metastatic potential. Teale, D.M., Rees, R.C., Clark, A., Potter, C.W. Int. J. Cancer (1984) [Pubmed]
  25. Expression and localization of prolactin messenger ribonucleic acid in the human immune system. Wu, H., Devi, R., Malarkey, W.B. Endocrinology (1996) [Pubmed]
  26. Localization of Fc gamma receptors and complement receptors CR1 on human peripheral nerve fibres by immunoelectron microscopy. Vedeler, C.A., Nilsen, R., Matre, R. J. Neuroimmunol. (1989) [Pubmed]
  27. Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence. Milas, L., Furuta, Y., Hunter, N., Nishiguchi, I., Runkel, S. Cancer Res. (1990) [Pubmed]
  28. Drug-mediated increase of tumor immunogenicity in vivo for a new approach to experimental cancer immunotherapy. Giampietri, A., Bonmassar, A., Puccetti, P., Circolo, A., Goldin, A., Bonmassar, E. Cancer Res. (1981) [Pubmed]
  29. Modulation of immunological competence in 1,2-dimethylhydrazine-sensitive SWR/J mice during colorectal carcinogenesis. Szakal, A.K., Diwan, B.A., Blackman, K.E. Cancer Res. (1980) [Pubmed]
  30. Influence of adult thymectomy on immunocompetence in patients with myasthenia gravis. Wijermans, P., Oosterhuis, H.J., Astaldi, G.C., Schellekens, P.T., Astaldi, A. J. Immunol. (1980) [Pubmed]
  31. Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Bryl, E., Vallejo, A.N., Matteson, E.L., Witkowski, J.M., Weyand, C.M., Goronzy, J.J. Arthritis Rheum. (2005) [Pubmed]
  32. Cross regulation by IL-10 and IL-2/IL-12 of the helper T cells and the cytolytic activity of lymphocytes from malignant effusions of lung cancer patients. Chen, Y.M., Yang, W.K., Ting, C.C., Tsai, W.Y., Yang, D.M., Whang-Peng, J., Perng, R.P. Chest (1997) [Pubmed]
  33. Secretion of IL-6, monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha, and TNFalpha by cultured intact human peritoneum. Riese, J., Denzel, C., Zowe, M., Mehler, C., Hohenberger, W., Haupt, W. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1999) [Pubmed]
  34. New aspects of prolactin and immunity: a lymphocyte-derived prolactin-like product and nuclear protein kinase C activation. Russell, D.H. Trends Pharmacol. Sci. (1989) [Pubmed]
  35. The mouse mutant "motheaten." II. Functional studies of the immune system. Sidman, C.L., Shultz, L.D., Unanue, E.R. J. Immunol. (1978) [Pubmed]
  36. Delayed recovery of CDR3 complexity of the T-cell receptor-beta chain in recipients of allogeneic bone marrow transplants who had virus-associated interstitial pneumonia: monitor of T-cell function by CDR3 spectratyping. Hirokawa, M., Horiuchi, T., Kitabayashi, A., Kawabata, Y., Matsutani, T., Suzuki, R., Chihara, J., Miura, A.B. J. Allergy Clin. Immunol. (2000) [Pubmed]
  37. The immunocompetence of residual lymphocytes at various stages of red cell cryopreservation with 40% w/v glycerol in an ionic medium at -80 C. Kurtz, S.R., Van Deinse, W.H., Valeri, C.R. Transfusion (1978) [Pubmed]
  38. Hepatitis C virus serotype-specific core and NS4 antibodies in injecting drug users participating in the Amsterdam cohort studies. Beld, M., Penning, M., van Putten, M., van den Hoek, A., Lukashov, V., McMorrow, M., Goudsmit, J. J. Clin. Microbiol. (1998) [Pubmed]
  39. Androgen control of immunocompetence in the male house finch, Carpodacus mexicanus Müller. Deviche, P., Cortez, L. J. Exp. Biol. (2005) [Pubmed]
WikiGenes - Universities