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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Comparative study of the effects of two bleaching agents on oral microbiota.

This study evaluated the in vivo effects of bleaching agents containing 10% carbamide peroxide (Platinum/Colgate) or 7.5% hydrogen peroxide (Day White 2Z/Discus Dental) on mutans Streptococcus during dental bleaching. The products were applied on 30 volunteers who needed dental bleaching. In each volunteer, one of the two bleaching agents was used on both dental arches one hour a day for three weeks. Analysis of the bacterial counts was made by collecting saliva before (baseline values), during (7 and 21 days) bleaching treatments and 14 days posttreatment. The Friedman non-parametric analysis (alpha=0.05) found no differences in microorganism counts at different times for each group for both agents (p>0.05). The Mann Whitney nonparametric test (alpha=0.05) showed no differences in micro-organism counts for both agents (p>0.05). Different bleaching agents did not change the oral cavity mutans Streptococcus counts.[1]


  1. Comparative study of the effects of two bleaching agents on oral microbiota. Alkmin, Y.T., Sartorelli, R., Flório, F.M., Basting, R.T. Operative dentistry. (2005) [Pubmed]
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