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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Mouth


Psychiatry related information on Mouth


High impact information on Mouth

  • BACKGROUND: 9-cis-Retinoic acid (9-cis-RA) and N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive agents against epithelial tumors in the oral cavity, breast, and prostate [9].
  • Here we show that SKALP is constitutively expressed in several epithelia that are continuously subjected to inflammatory stimuli, such as the oral cavity and the vagina where it co-localizes with type 1 TGase [10].
  • CONCLUSIONS: Systemic absorption of nicotine, sodium, and carcinogenic chemicals from smokeless tobacco may cause or aggravate human illness in addition to the known adverse effects on the oral cavity [11].
  • Oral-facial-digital type 1 syndrome (OFD1 [MIM 311200]) is transmitted as an X-linked dominant condition with lethality in males and is characterized by malformations of the face, oral cavity, and digits, and by a highly variable expressivity even within the same family [12].
  • In rat and mouse embryos, nonneuronal structures around the oral cavity and in hip and shoulder regions also expressed the Prx3 gene [13].

Chemical compound and disease context of Mouth


Biological context of Mouth


Anatomical context of Mouth


Associations of Mouth with chemical compounds


Gene context of Mouth

  • Together, these results suggest that this subject does not express the PRB3 gene and that one of the consequences is an altered ability to interact with a bacterium known to colonize the oral cavity [34].
  • Location of the tumour in the oral cavity and EGFR expression had independent prognostic value for overall survival (OS) [35].
  • Thus, expression of VPF/VEGF and its receptors is markedly increased in high-grade squamous dysplasia and invasive squamous cell carcinoma of the oral cavity and larynx and may play an important role in the angiogenesis associated with these lesions [36].
  • CCND1 GG was associated with G3 tumors in the oral cavity/pharyngeal (P = 0.011), but not laryngeal, SCC cases [37].
  • Thus, GSTT1 null was associated with T3/T4 lesions in the oral cavity/pharyngeal (P = 0.029), but not laryngeal, SCC cases [37].

Analytical, diagnostic and therapeutic context of Mouth


  1. Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia. Sueoka, E., Sueoka, N., Goto, Y., Matsuyama, S., Nishimura, H., Sato, M., Fujimura, S., Chiba, H., Fujiki, H. Cancer Res. (2001) [Pubmed]
  2. High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers. Jourenkova-Mironova, N., Mitrunen, K., Bouchardy, C., Dayer, P., Benhamou, S., Hirvonen, A. Cancer Res. (2000) [Pubmed]
  3. Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer. Schneider-Stock, R., Mawrin, C., Motsch, C., Boltze, C., Peters, B., Hartig, R., Buhtz, P., Giers, A., Rohrbeck, A., Freigang, B., Roessner, A. Am. J. Pathol. (2004) [Pubmed]
  4. Anatomic dissociation between HIV-1 and its endogenous inhibitor in mucosal tissues. Wahl, S.M., Worley, P., Jin, W., McNeely, T.B., Eisenberg, S., Fasching, C., Orenstein, J.M., Janoff, E.N. Am. J. Pathol. (1997) [Pubmed]
  5. A neuraminidase from Streptococcus sanguis that can release O-acetylated sialic acids. Varki, A., Diaz, S. J. Biol. Chem. (1983) [Pubmed]
  6. Xylitol-induced increase of lactoperoxidase activity. Mäkinen, K.K., Tenovuo, J., Scheinin, A. J. Dent. Res. (1976) [Pubmed]
  7. Onset and duration of hypoalgesia of lidocaine spray applied to oral mucosa--a dose response study. Schønemann, N.K., van der Burght, M., Arendt-Nielsen, L., Bjerring, P. Acta anaesthesiologica Scandinavica. (1992) [Pubmed]
  8. Differences in coping style and locus of control between older and younger patients with head and neck cancer. Derks, W., Leeuw, J.R., Hordijk, G.J., Winnubst, J.A. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. (2005) [Pubmed]
  9. Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. Gupta, A., Nines, R., Rodrigo, K.A., Aziz, R.A., Carlton, P.S., Gray, D.L., Steele, V.E., Morse, M.A., Stoner, G.D. J. Natl. Cancer Inst. (2001) [Pubmed]
  10. Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. Pfundt, R., van Ruissen, F., van Vlijmen-Willems, I.M., Alkemade, H.A., Zeeuwen, P.L., Jap, P.H., Dijkman, H., Fransen, J., Croes, H., van Erp, P.E., Schalkwijk, J. J. Clin. Invest. (1996) [Pubmed]
  11. Daily use of smokeless tobacco: systemic effects. Benowitz, N.L., Jacob, P., Yu, L. Ann. Intern. Med. (1989) [Pubmed]
  12. Identification of the gene for oral-facial-digital type I syndrome. Ferrante, M.I., Giorgio, G., Feather, S.A., Bulfone, A., Wright, V., Ghiani, M., Selicorni, A., Gammaro, L., Scolari, F., Woolf, A.S., Sylvie, O., Bernard, L., Malcolm, S., Winter, R., Ballabio, A., Franco, B. Am. J. Hum. Genet. (2001) [Pubmed]
  13. Homeobox gene Prx3 expression in rodent brain and extraneural tissues. van Schaick, H.S., Smidt, M.P., Rovescalli, A.C., Luijten, M., van der Kleij, A.A., Asoh, S., Kozak, C.A., Nirenberg, M., Burbach, J.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  14. Functional Relevance of Urinary-type Plasminogen Activator Receptor-{alpha}3beta1 Integrin Association in Proteinase Regulatory Pathways. Ghosh, S., Johnson, J.J., Sen, R., Mukhopadhyay, S., Liu, Y., Zhang, F., Wei, Y., Chapman, H.A., Stack, M.S. J. Biol. Chem. (2006) [Pubmed]
  15. Identification and treatment of infections in multiply traumatized patients. Caplan, E.S., Hoyt, N.J. Am. J. Med. (1985) [Pubmed]
  16. p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomas. Shahnavaz, S.A., Regezi, J.A., Bradley, G., Dubé, I.D., Jordan, R.C. J. Pathol. (2000) [Pubmed]
  17. Prevalence of tetracycline resistance genes in oral bacteria. Villedieu, A., Diaz-Torres, M.L., Hunt, N., McNab, R., Spratt, D.A., Wilson, M., Mullany, P. Antimicrob. Agents Chemother. (2003) [Pubmed]
  18. Oral presentation of posttransplantation lymphoproliferative disorders. An unusual manifestation. Oda, D., Persson, G.R., Haigh, W.G., Sabath, D.E., Penn, I., Aziz, S. Transplantation (1996) [Pubmed]
  19. Role of the oropharynx in regulation of glycemia. Proietto, J., Rohner-Jeanrenaud, F., Ionescu, E., Jeanrenaud, B. Diabetes (1987) [Pubmed]
  20. Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity. Jordan, R.C., Bradley, G., Slingerland, J. Am. J. Pathol. (1998) [Pubmed]
  21. Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. Matthias, C., Branigan, K., Jahnke, V., Leder, K., Haas, J., Heighway, J., Jones, P.W., Strange, R.C., Fryer, A.A., Hoban, P.R. Clin. Cancer Res. (1998) [Pubmed]
  22. Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity. Juarez, J., Clayman, G., Nakajima, M., Tanabe, K.K., Saya, H., Nicolson, G.L., Boyd, D. Int. J. Cancer (1993) [Pubmed]
  23. Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods. Fujita, Y., Wakabayashi, K., Takayama, S., Nagao, M., Sugimura, T. Carcinogenesis (1987) [Pubmed]
  24. Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. Miliani de Marval, P.L., Macias, E., Rounbehler, R., Sicinski, P., Kiyokawa, H., Johnson, D.G., Conti, C.J., Rodriguez-Puebla, M.L. Mol. Cell. Biol. (2004) [Pubmed]
  25. Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Rinaldi, A.L., Morse, M.A., Fields, H.W., Rothas, D.A., Pei, P., Rodrigo, K.A., Renner, R.J., Mallery, S.R. Cancer Res. (2002) [Pubmed]
  26. Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: an update. Marti, U., Burwen, S.J., Jones, A.L. Hepatology (1989) [Pubmed]
  27. Serotonin and morphogenesis. I. Sites of serotonin uptake and -binding protein immunoreactivity in the midgestation mouse embryo. Lauder, J.M., Tamir, H., Sadler, T.W. Development (1988) [Pubmed]
  28. Mouse skin carcinogenicity tests of the flame retardants tris(2,3-dibromopropyl)phosphate, tetrakis(hydroxymethyl)phosphonium chloride, and polyvinyl bromide. Van Duuren, B.L., Loewengart, G., Seidman, I., Smith, A.C., Melchionne, S. Cancer Res. (1978) [Pubmed]
  29. Loss of a novel mucin-like epithelial glycoprotein in oral and cervical squamous cell carcinomas. Nielsen, P.A., Mandel, U., Therkildsen, M.H., Ravn, V., David, L., Reis, C.A., Wandall, H.H., Dabelsteen, E., Clausen, H. Cancer Res. (1997) [Pubmed]
  30. Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. Hecht, S.S., Rivenson, A., Braley, J., DiBello, J., Adams, J.D., Hoffmann, D. Cancer Res. (1986) [Pubmed]
  31. Comparative metabolism of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured F344 rat oral tissue and esophagus. Murphy, S.E., Heiblum, R., Trushin, N. Cancer Res. (1990) [Pubmed]
  32. Effects of route of administration and dose on the carcinogenicity of N-nitrosodiethanolamine in the Syrian golden hamster. Hoffman, D., Rivenson, A., Adams, J.D., Juchatz, A., Vinchkoski, N., Hecht, S.S. Cancer Res. (1983) [Pubmed]
  33. Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva. Freije, J.P., Balbín, M., Abrahamson, M., Velasco, G., Dalbøge, H., Grubb, A., López-Otín, C. J. Biol. Chem. (1993) [Pubmed]
  34. PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. Azen, E., Prakobphol, A., Fisher, S.J. Infect. Immun. (1993) [Pubmed]
  35. Prognostic value of the epidermal growth factor receptor (EGRF) and p53 in advanced head and neck squamous cell carcinoma patients treated with induction chemotherapy. Hitt, R., Ciruelos, E., Amador, M.L., Benito, A., Sanchez, J.J., Ballestin, C., Cortes-Funes, H. Eur. J. Cancer (2005) [Pubmed]
  36. Vascular permeability factor/vascular endothelial growth factor and its receptors in oral and laryngeal squamous cell carcinoma and dysplasia. Denhart, B.C., Guidi, A.J., Tognazzi, K., Dvorak, H.F., Brown, L.F. Lab. Invest. (1997) [Pubmed]
  37. Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis. Matthias, C., Jahnke, V., Jones, P.W., Hoban, P.R., Alldersea, J.E., Worrall, S.F., Fryer, A.A., Strange, R.C. Cancer Epidemiol. Biomarkers Prev. (1999) [Pubmed]
  38. Oral lactoferrin treatment of experimental oral candidiasis in mice. Takakura, N., Wakabayashi, H., Ishibashi, H., Teraguchi, S., Tamura, Y., Yamaguchi, H., Abe, S. Antimicrob. Agents Chemother. (2003) [Pubmed]
  39. Multiple regions of deletion on chromosome arm 13q in head-and-neck squamous-cell carcinoma. Gupta, V.K., Schmidt, A.P., Pashia, M.E., Sunwoo, J.B., Scholnick, S.B. Int. J. Cancer (1999) [Pubmed]
  40. Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx. Fazekas, J.T., Sommer, C., Kramer, S. Int. J. Radiat. Oncol. Biol. Phys. (1980) [Pubmed]
  41. Oral plasmablastic lymphomas in AIDS patients are associated with human herpesvirus 8. Cioc, A.M., Allen, C., Kalmar, J.R., Suster, S., Baiocchi, R., Nuovo, G.J. Am. J. Surg. Pathol. (2004) [Pubmed]
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