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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Boc-protected amines via a mild and efficient one-pot Curtius rearrangement.

[reaction: see text] The reaction of a carboxylic acid with di-tert-butyl dicarbonate and sodium azide allowed the formation of an acyl azide intermediate, which undergoes a Curtius rearrangement in the presence of tetrabutylammonium bromide and zinc(II) triflate. The trapping of the isocyanate derivative in the reaction mixture led to the desired tert-butyl carbamate in high yields at low temperature. These reaction conditions are compatible with a variety of substrates, including malonate derivatives, which provide access to protected amino acids.[1]

References

  1. Boc-protected amines via a mild and efficient one-pot Curtius rearrangement. Lebel, H., Leogane, O. Org. Lett. (2005) [Pubmed]
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