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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells.

UDP-glucose dehydrogenase (UGDH) catalyzes two oxidations of UDP-glucose to yield UDP-glucuronic acid. Pathological over-production of extracellular matrix components may be linked to the availability of UDP-glucuronic acid, therefore UGDH is a potential therapeutic target. RNA interference (RNAi) has been adapted to knock down the expression of human UGDH. A UGDH siRNA plasmid was constructed using a pRNA-U6.1/Neo vector and transfected into breast cancer cells, ZR-75-1, with an efficiency of up to 50%. Western blot analysis showed that the UGDH expression was efficiently knocked down at protein levels by RNAi in ZR-75-1 cells.[1]

References

  1. Inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells. Huh, J.W., Choi, M.M., Yang, S.J., Yoon, S.Y., Choi, S.Y., Cho, S.W. Biotechnol. Lett. (2005) [Pubmed]
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