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Chemical Compound Review

UDPGA     (2S,3S,4S,5R,6R)-6- [[[(2R,3S,4R,5R)-5-(2,4...

Synonyms: UDPglucuronate, udp-glcua, CHEMBL228057, CHEBI:17200, HMDB00935, ...
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Disease relevance of Uridine diphosphoglucuronic acid


High impact information on Uridine diphosphoglucuronic acid


Chemical compound and disease context of Uridine diphosphoglucuronic acid


Biological context of Uridine diphosphoglucuronic acid


Anatomical context of Uridine diphosphoglucuronic acid


Associations of Uridine diphosphoglucuronic acid with other chemical compounds


Gene context of Uridine diphosphoglucuronic acid

  • Pathological overproduction of extracellular matrix components may be linked to the availability of UDP-glucuronic acid; therefore UGDH is an intriguing therapeutic target [29].
  • In contrast, the Michaelis-Menten kinetics for UDPGA observed with UGT2B7 (K(m)(app) 493.2 microM) suggested that kinetic interactions with UGTs were specific to the xenobiotic substrate and the co-substrate (UDPGA) [30].
  • SLC35D2 was localized in the Golgi membrane and exhibited around 50% similarity with three nucleotide sugar transporters: human SLC35D1 (UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter), fruitfly fringe connection (frc) transporter, and nematode SQV-7 transporter, the latter two being involved in developmental and organogenetic processes [31].
  • Despite the identical primary structure of the C-terminal halves of the UGT1A isoforms, there were marked differences in the respective K(m) values for UDPGA, ranging from 52 microM for UGT1A6 to 1256 microM for UGT1A8 [32].
  • The glucuronidation of entacapone by UGT1A9 was inhibited by 1-naphthol in a competitive fashion, with respect to entacapone, and an uncompetitive fashion, with respect to UDP-glucuronic acid (UDPGA) [32].

Analytical, diagnostic and therapeutic context of Uridine diphosphoglucuronic acid


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  12. Effect of glutathione and uridine 5'-diphosphoglucuronic acid on mutagenesis by benzo[a]pyrene and aflatoxin B1 in the Salmonella/microsome assay. Malaveille, C., Brun, G., Hautefeuille, A., Bartsch, H. Mutat. Res. (1981) [Pubmed]
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  15. Distribution of UDPglucuronosyltransferase in rat tissue. Chowdhury, J.R., Novikoff, P.M., Chowdhury, N.R., Novikoff, A.B. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  16. Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling. Binari, R.C., Staveley, B.E., Johnson, W.A., Godavarti, R., Sasisekharan, R., Manoukian, A.S. Development (1997) [Pubmed]
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  18. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. Breazeale, S.D., Ribeiro, A.A., McClerren, A.L., Raetz, C.R. J. Biol. Chem. (2005) [Pubmed]
  19. Calcium-mediated inhibition of glucuronide production by epinephrine in the perfused rat liver. Belinsky, S.A., Kauffman, F.C., Sokolove, P.M., Tsukuda, T., Thurman, R.G. J. Biol. Chem. (1984) [Pubmed]
  20. Bilirubin diglucuronide synthesis by a UDP-glucuronic acid-dependent enzyme system in rat liver microsomes. Blanckaert, N., Gollan, J., Schmid, R. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  21. Defective function of a microsomal UDP-glucuronyltransferase in Gunn rats. Nakata, D., Zakim, D., Vessey, D.A. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
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  24. UDP-glucuronate carboxy-lyase in cultured chondrocytes. John, K.V., Schwartz, N.B., Ankel, H. J. Biol. Chem. (1977) [Pubmed]
  25. Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. Breazeale, S.D., Ribeiro, A.A., Raetz, C.R. J. Biol. Chem. (2002) [Pubmed]
  26. Mutational Analysis of the Medicago Glycosyltransferase UGT71G1 Reveals Residues That Control Regioselectivity for (Iso)flavonoid Glycosylation. He, X.Z., Wang, X., Dixon, R.A. J. Biol. Chem. (2006) [Pubmed]
  27. The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues. Ouzzine, M., Gulberti, S., Levoin, N., Netter, P., Magdalou, J., Fournel-Gigleux, S. J. Biol. Chem. (2002) [Pubmed]
  28. Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4. Pillot, T., Ouzzine, M., Fournel-Gigleux, S., Lafaurie, C., Radominska, A., Burchell, B., Siest, G., Magdalou, J. J. Biol. Chem. (1993) [Pubmed]
  29. Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations. Sommer, B.J., Barycki, J.J., Simpson, M.A. J. Biol. Chem. (2004) [Pubmed]
  30. Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7. Tsoutsikos, P., Miners, J.O., Stapleton, A., Thomas, A., Sallustio, B.C., Knights, K.M. Biochem. Pharmacol. (2004) [Pubmed]
  31. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Ishida, N., Kuba, T., Aoki, K., Miyatake, S., Kawakita, M., Sanai, Y. Genomics (2005) [Pubmed]
  32. Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Luukkanen, L., Taskinen, J., Kurkela, M., Kostiainen, R., Hirvonen, J., Finel, M. Drug Metab. Dispos. (2005) [Pubmed]
  33. Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Gouze, J.N., Bordji, K., Gulberti, S., Terlain, B., Netter, P., Magdalou, J., Fournel-Gigleux, S., Ouzzine, M. Arthritis Rheum. (2001) [Pubmed]
  34. Separation and allosteric properties of two forms of UDP-glucuronate carboxy-lyase. John, K.V., Schutzbach, J.S., Ankel, H. J. Biol. Chem. (1977) [Pubmed]
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  36. Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus. Quirós, L.M., Aguirrezabalaga, I., Olano, C., Méndez, C., Salas, J.A. Mol. Microbiol. (1998) [Pubmed]
  37. Characterisation and expression of the pathway from UDP-glucose to UDP-xylose in differentiating tobacco tissue. Bindschedler, L.V., Wheatley, E., Gay, E., Cole, J., Cottage, A., Bolwell, G.P. Plant Mol. Biol. (2005) [Pubmed]
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