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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Role of epiregulin in peptidoglycan- induced proinflammatory cytokine production by antigen presenting cells.

We have previously found that epiregulin, a member of epidermal growth factor superfamily, is involved in proinflammatory cytokine production in bone marrow-derived macrophages. In this report, to further assess the role of epiregulin in innate immunity, we measured IL-6 production levels upon lipopolysaccharide and peptidoglycan stimulation in antigen presenting cells including macrophages and dendritic cells. Our analyses using epiregulin-deficient mice with mixed and inbred genetic backgrounds revealed that epiregulin deficiency results in the reduction of IL-6 production levels in both cell types upon peptidoglycan stimulation, and that the extent of this reduction is more evident under the BALB/c background compared with the C57BL/6J background. These results indicated that epiregulin may have a critical role in the regulation of peptidoglycan- mediated proinflammatory cytokine production in antigen presenting cells and innate immunity.[1]

References

  1. Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Sugiyama, S., Nakabayashi, K., Baba, I., Sasazuki, T., Shirasawa, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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