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Gene Review

Ereg  -  epiregulin

Mus musculus

Synonyms: EPR, Proepiregulin
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Disease relevance of Ereg


High impact information on Ereg


Biological context of Ereg


Anatomical context of Ereg


Associations of Ereg with chemical compounds


Physical interactions of Ereg


Regulatory relationships of Ereg


Other interactions of Ereg


Analytical, diagnostic and therapeutic context of Ereg


  1. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Lee, D., Pearsall, R.S., Das, S., Dey, S.K., Godfrey, V.L., Threadgill, D.W. Mol. Cell. Biol. (2004) [Pubmed]
  2. Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Shirasawa, S., Sugiyama, S., Baba, I., Inokuchi, J., Sekine, S., Ogino, K., Kawamura, Y., Dohi, T., Fujimoto, M., Sasazuki, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation-impact of specific HER1 inhibition. Tørring, N., Hansen, F.D., Sørensen, B.S., Ørntoft, T.F., Nexø, E. Prostate (2005) [Pubmed]
  4. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells. Baba, I., Shirasawa, S., Iwamoto, R., Okumura, K., Tsunoda, T., Nishioka, M., Fukuyama, K., Yamamoto, K., Mekada, E., Sasazuki, T. Cancer Res. (2000) [Pubmed]
  5. Molecular cloning of mouse epiregulin, a novel epidermal growth factor-related protein, expressed in the early stage of development. Toyoda, H., Komurasaki, T., Ikeda, Y., Yoshimoto, M., Morimoto, S. FEBS Lett. (1995) [Pubmed]
  6. Epiregulin stimulates proliferation of rabbit gastric cells in primary culture through autophosphorylation of the epidermal growth factor receptor. Sasaki, E., Arakawa, T., Fujiwara, Y., Kawada, N., Fukuda, T., Higuchi, K., Komurasaki, T., Kobayashi, K. Eur. J. Pharmacol. (1997) [Pubmed]
  7. Role of epiregulin in peptidoglycan-induced proinflammatory cytokine production by antigen presenting cells. Sugiyama, S., Nakabayashi, K., Baba, I., Sasazuki, T., Shirasawa, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Patel, R.D., Kim, D.J., Peters, J.M., Perdew, G.H. Toxicol. Sci. (2006) [Pubmed]
  9. Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. Toyoda, H., Komurasaki, T., Uchida, D., Takayama, Y., Isobe, T., Okuyama, T., Hanada, K. J. Biol. Chem. (1995) [Pubmed]
  10. Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the "window" of implantation. Das, S.K., Das, N., Wang, J., Lim, H., Schryver, B., Plowman, G.D., Dey, S.K. Dev. Biol. (1997) [Pubmed]
  11. Effect of epiregulin on pancreatic beta cell growth and insulin secretion. Kuntz, E., Broca, C., Komurasaki, T., Kaltenbacher, M.C., Gross, R., Pinget, M., Damgé, C. Growth Factors (2005) [Pubmed]
  12. Topical epiregulin enhances repair of murine excisional wounds. Draper, B.K., Komurasaki, T., Davidson, M.K., Nanney, L.B. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2003) [Pubmed]
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