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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Developmental regulation of Foxp3 expression during ontogeny.

Thymectomy of neonatal mice can result in the development of autoimmune pathology. It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the development of autoimmune disease in neonatally thymectomized mice is caused by the escape of self-reactive T cells before thymectomy without accompanying T reg cells. However, the kinetics of T reg cell production within the thymus during ontogeny has not been assessed. We demonstrate that the development of Foxp3-expressing T reg cells is substantially delayed relative to nonregulatory thymocytes during ontogeny. Based on our data, we speculate that induction of Foxp3 in developing thymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla.[1]

References

  1. Developmental regulation of Foxp3 expression during ontogeny. Fontenot, J.D., Dooley, J.L., Farr, A.G., Rudensky, A.Y. J. Exp. Med. (2005) [Pubmed]
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