- Inactivation of Ku-mediated end joining suppresses mec1Delta lethality by depleting the ribonucleotide reductase inhibitor Sml1 through a pathway controlled by Tel1 kinase and the Mre11 complex. Corda, Y., Lee, S.E., Guillot, S., Walther, A., Sollier, J., Arbel-Eden, A., Haber, J.E., Géli, V. Mol. Cell. Biol. (2005)