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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Human herpesvirus 6 (HHV-6) U94/REP protein inhibits betaherpesvirus replication.

Human herpesvirus 6 (HHV-6) is the only human herpesvirus encoding U94/rep, homologue to the parvovirus non-structural gene rep68/78. Results to date suggest that HHV-6 U94/rep might regulate viral gene expression and have a role in viral latency. To determine the effect of U94/REP upon viral replication, the protein was produced. The purified U94/REP retained the characteristic immunological features. It was internalized and localized in the nucleus of human cells, showing marked inhibitory activity on the replication of HHV-6 (both variants A and B). The effect of U94/REP was dose-dependent and sensitive to treatment with single-stranded but not double-stranded DNA. U94/REP inhibited the replication of other betaherpesviruses, HHV-7 and human cytomegalovirus, but had no effect on herpes simplex virus. These results confirm the action of U94/rep latency gene in the regulation of HHV-6 replication with implications for co-reactivations and latency of human betaherpesviruses.[1]


  1. Human herpesvirus 6 (HHV-6) U94/REP protein inhibits betaherpesvirus replication. Caselli, E., Bracci, A., Galvan, M., Boni, M., Rotola, A., Bergamini, C., Cermelli, C., Dal Monte, P., Gompels, U.A., Cassai, E., Di Luca, D. Virology (2006) [Pubmed]
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