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U94  -  U94, Rep

Human herpesvirus 6A

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Disease relevance of U94

  • These results confirm the action of U94/rep latency gene in the regulation of HHV-6 replication with implications for co-reactivations and latency of human betaherpesviruses [1].
  • Human herpesvirus 6 (HHV-6) is the only human herpesvirus encoding U94/rep, homologue to the parvovirus non-structural gene rep68/78 [1].
  • U94/REP inhibited the replication of other betaherpesviruses, HHV-7 and human cytomegalovirus, but had no effect on herpes simplex virus [1].

High impact information on U94


Analytical, diagnostic and therapeutic context of U94

  • Quantitative RT-PCR and PCR with primers specific for MSRV/HERV-W env and pol and HHV-6 U94/rep and DNA-pol were used to determine virus copy numbers [2].


  1. Human herpesvirus 6 (HHV-6) U94/REP protein inhibits betaherpesvirus replication. Caselli, E., Bracci, A., Galvan, M., Boni, M., Rotola, A., Bergamini, C., Cermelli, C., Dal Monte, P., Gompels, U.A., Cassai, E., Di Luca, D. Virology (2006) [Pubmed]
  2. Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6. Mameli, G., Astone, V., Arru, G., Marconi, S., Lovato, L., Serra, C., Sotgiu, S., Bonetti, B., Dolei, A. J. Gen. Virol. (2007) [Pubmed]
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