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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Visual acuities and scotomas after one week levodopa administration in human amblyopia.

The authors previously showed that a single dose of levodopa improves the contrast sensitivity and decreases the size of fixation point scotomas in amblyopic patients. In the present study, they investigated the effect of levodopa after 1 wk of daily administration using a cross-over, double masked design. The decrease of fixation point scotomas was confirmed with automatic static perimetry. An improvement of visual acuity occurred in 70% of the patients after 1 wk of levodopa administration compared to only 22% in the authors' previous study using one single dose. The improvements in visual acuities and visual fields persisted even after the levodopa administration was completed.[1]


  1. Visual acuities and scotomas after one week levodopa administration in human amblyopia. Gottlob, I., Charlier, J., Reinecke, R.D. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
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