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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Scotoma


High impact information on Scotoma

  • X-linked progressive cone dystrophy (COD1) causes progressive deterioration of visual acuity, deepening of central scotomas, macular changes, and bull's-eye lesions [6].
  • CONCLUSIONS: Changes in temporal tuning (both psychophysical and electroretinographic) were found only within visual field scotomas, whereas changes of the log sensitivity parameter were found also in the relatively preserved foveas of this group of patients with early stage RP [7].
  • The authors previously showed that a single dose of levodopa improves the contrast sensitivity and decreases the size of fixation point scotomas in amblyopic patients [8].
  • In conclusion, we found a short-term effect of levodopa on contrast sensitivity and fixation point scotomas in amblyopic eyes of adult patients [1].
  • Reading with a macular scotoma. II. Retinal locus for scanning text [9].

Chemical compound and disease context of Scotoma

  • These subjects had circumscribed hypopigmented maculae, retinal pigment epithelial window defects on fluorescein angiography, central scotomas, and electrophysiologic studies, ranging from normal to severely abnormal [10].
  • In the cefepime treated group the following side-effects were noted: headache (5), fatigue (4), nausea/stomach ache (2), soft stool (2), transient scotoma (1) [11].
  • Bilateral acute visual loss characterized by cecocentral scotomas and acquired dyschromatopsia developed in a patient receiving large oral doses of ciprofloxacin hydrochloride (Cipro) [12].
  • This paper presents an afferent excitatory synaptic plasticity rule and a lateral inhibitory synaptic plasticity rule--the EXIN rules (Marshall, 1995)--to model persistent RF changes after artificial scotoma conditioning and retinal lesions [13].
  • The patient was treated with doxycycline and made a dramatic improvement to visual acuity of 20/30 with a minimal residual relative central scotoma [14].

Anatomical context of Scotoma


Gene context of Scotoma

  • Hence, location of the scotoma predicted direction of the shift of the egocentric midline but not degree of shift [16].
  • They had progressive axial myopia starting at 6 and 12 years of age and later paracentral scotomas leading to poor central vision [17].
  • In conclusion, only 36% of subjects with strabismus were found to have a suppression scotoma [18].
  • After cataract surgery, the CPSD index worsened in many subjects with dense scotomas [19].
  • Reading performance for rapid serial visual presentation (RSVP) was compared to conventional text presentation (PAGE) in 14 subjects with dense central scotomas (central field loss, CFL) and 9 without central scotomas (noCFL) [20].

Analytical, diagnostic and therapeutic context of Scotoma


  1. Effect of levodopa on contrast sensitivity and scotomas in human amblyopia. Gottlob, I., Stangler-Zuschrott, E. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  2. Fixation patterns and reading rates in eyes with central scotomas from advanced atrophic age-related macular degeneration and Stargardt disease. Sunness, J.S., Applegate, C.A., Haselwood, D., Rubin, G.S. Ophthalmology (1996) [Pubmed]
  3. Psychophysics of reading--XIII. Predictors of magnifier-aided reading speed in low vision. Ahn, S.J., Legge, G.E. Vision Res. (1995) [Pubmed]
  4. Post-traumatic headache with scintillating scotoma treated with phenytoin (Dilantin). Robbins, L. Headache. (1989) [Pubmed]
  5. Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations. Brown, M.D., Allen, J.C., Van Stavern, G.P., Newman, N.J., Wallace, D.C. Am. J. Med. Genet. (2001) [Pubmed]
  6. Clinical diversity and chromosomal localization of X-linked cone dystrophy (COD1). Hong, H.K., Ferrell, R.E., Gorin, M.B. Am. J. Hum. Genet. (1994) [Pubmed]
  7. Photopic temporal processing in retinitis pigmentosa. Felius, J., Swanson, W.H. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  8. Visual acuities and scotomas after one week levodopa administration in human amblyopia. Gottlob, I., Charlier, J., Reinecke, R.D. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  9. Reading with a macular scotoma. II. Retinal locus for scanning text. Timberlake, G.T., Peli, E., Essock, E.A., Augliere, R.A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  10. The variable expressivity of a family with central areolar pigment epithelial dystrophy. Keithahn, M.A., Huang, M., Keltner, J.L., Small, K.W., Morse, L.S. Ophthalmology (1996) [Pubmed]
  11. Multiple dose pharmacokinetics, safety, and effects on faecal microflora, of cefepime in healthy volunteers. Bächer, K., Schaeffer, M., Lode, H., Nord, C.E., Borner, K., Koeppe, P. J. Antimicrob. Chemother. (1992) [Pubmed]
  12. Reversible visual loss in a patient receiving high-dose ciprofloxacin hydrochloride (Cipro). Vrabec, T.R., Sergott, R.C., Jaeger, E.A., Savino, P.J., Bosley, T.M. Ophthalmology (1990) [Pubmed]
  13. Models of receptive-field dynamics in visual cortex. Kalarickal, G.J., Marshall, J.A. Vis. Neurosci. (1999) [Pubmed]
  14. Optic disk edema with a macular star. Ghauri, R.R., Lee, A.G. Survey of ophthalmology. (1998) [Pubmed]
  15. Anterior ischemic optic neuropathy after a trans-Atlantic airplane journey. Kaiserman, I., Frucht-Pery, J. Am. J. Ophthalmol. (2002) [Pubmed]
  16. Displacement of the egocentric visual midline in altitudinal postchiasmatic scotomata. Kerkhoff, G. Neuropsychologia. (1993) [Pubmed]
  17. Ophthalmologic findings in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation: a new type of hereditary metabolic chorioretinopathy. Tyni, T., Kivelä, T., Lappi, M., Summanen, P., Nikoskelainen, E., Pihko, H. Ophthalmology (1998) [Pubmed]
  18. Quantitative perimetry under binocular viewing conditions in microstrabismus. Joosse, M.V., Simonsz, H.J., van Minderhout, H.M., de Jong, P.T., Noordzij, B., Mulder, P.G. Vision Res. (1997) [Pubmed]
  19. Effect of cataract extraction on the results of automated perimetry in glaucoma. Smith, S.D., Katz, J., Quigley, H.A. Arch. Ophthalmol. (1997) [Pubmed]
  20. Low vision reading with sequential word presentation. Rubin, G.S., Turano, K. Vision Res. (1994) [Pubmed]
  21. Scotoma and fixation patterns using scanning laser ophthalmoscope microperimetry in patients with macular dystrophy. Mori, F., Ishiko, S., Kitaya, N., Takamiya, A., Sato, E., Hikichi, T., Yoshida, A. Am. J. Ophthalmol. (2001) [Pubmed]
  22. Characteristics of AMD patients with low vision receiving visual rehabilitation. Schuchard, R.A., Naseer, S., de Castro, K. Journal of rehabilitation research and development. (1999) [Pubmed]
  23. Leber's hereditary optic neuroretinopathy (LHON) associated with mitochondrial DNA point mutation G11778A in two Croatian families. Martin-Kleiner, I., Gabrilovac, J., Bradvica, M., Vidović, T., Cerovski, B., Fumić, K., Boranić, M. Collegium antropologicum. (2006) [Pubmed]
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