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MeSH Review


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Disease relevance of Perimetry


High impact information on Perimetry

  • METHODS: Ophthalmologic tests including Goldmann perimetry were performed on 32 adult patients on long-term successful vigabatrin monotherapy (treatment duration 29 to 119 months) and on 18 patients on carbamazepine monotherapy (treatment duration 32 to 108 months) [6].
  • CONCLUSIONS: OCT of the RNFL can efficiently identify vigabatrin-induced damage and will be useful for adults and children unable to perform perimetry and when the perimetric outcome is equivocal [7].
  • PURPOSE: To compare test results from second-generation Frequency-Doubling Technology perimetry (FDT2, Humphrey Matrix; Carl-Zeiss Meditec, Dublin, CA) and standard automated perimetry (SAP) in patients with glaucoma [8].
  • METHODS: Thirteen members of a four-generation, nonconsanguineous British family were examined clinically and also underwent automated perimetry, fundus fluorescein angiography, and fundus autofluorescence imaging [9].
  • Effect of myopia on frequency-doubling perimetry [10].

Biological context of Perimetry


Anatomical context of Perimetry

  • RESULTS: A monocular enlarged blind spot was found on automated perimetry; fluorescein angiography showed a hypofluorescent peripapillary atrophic area and indocyanine green angiography highlighted diffuse, small hypofluorescent spots scattered throughout the posterior pole [16].
  • Malignant melanomas of the choroid that on fluorescein angiography and perimetry gave the impression of naevi [17].
  • All patients periodically underwent the following tests: 1) circadian IOP curve; 2) standard automated perimetry (SAP, Humphrey 30-2 SITA test); 3) short wavelength automated perimetry (SWAP); 4) frequency doubling technology perimetry (FDT, N-30 threshold test); 5) nerve fiber layer analysis with GDx; 6) ibopamine test; 7) ultrasonic pachymetry [18].
  • In 13 patients with diabetic retinopathy who had localised scotomata in the central visual field that could not be ascribed to haemorrhages, cotton wool spots or hard exudates, visual field data obtained by computerised perimetry were correlated with the corresponding retinal morphology as seen on fundus photographs and fluorescein angiograms [19].

Associations of Perimetry with chemical compounds

  • Using trained rhesus monkey subjects, the relative sensitivities of the vision mechanisms for the detection of perimetry test stimuli were determined through psychophysical measurements of spectral sensitivity at each of the test field locations of the C24-2 threshold program on the Humphrey Field Analyzer (Allergan Humphrey, San Leandro, CA) [20].
  • Effects of pupillary dilation on automated perimetry in glaucoma patients receiving pilocarpine [21].
  • Automated static threshold perimetry was performed on 64 eyes of 36 patients before and after modified grid therapy with the argon green or krypton red laser [22].
  • The effects of pupillary dilation (tropicamide 1%) on automated static threshold perimetry were studied in 18 normal subjects using the Humphrey field analyzer 30-2 and STATPAC programs [23].
  • METHODS: Subjects participating in the Rotterdam Study (n = 4178; ages, 55 years and older) were examined according to standard protocols, including a medical history interview, perimetry, applanation tonometry, funduscopy, and a nonfasting glucose tolerance test [24].

Gene context of Perimetry

  • METHODS: Eleven carriers from two families with XLRP and mutations in RPGR underwent clinical examination including fundus photography, AF, full-field electroretinography, Goldmann kinetic perimetry and two-colour threshold perimetry (2CT perimetry) [25].
  • METHODS: Two pairs of siblings with STGD1, for whom diagnosis had been confirmed by genetic linkage to the ABCA4 gene region, were examined regarding visual acuity, kinetic perimetry, fundus photography, full-field ERG and multifocal ERG (MERG) [26].
  • METHODS: A retrospective analysis was performed of 108 well characterised NTG patients who had been genotyped for OPA1 variations, and who had previously undergone automated perimetry and Heidelberg retina tomography (HRT) [27].
  • The findings made by perimetry suggest that the nerve fiber bundles in the nasal field (retina temporal to the fovea) may have a greater potential to recover function in LHON patients [28].
  • Repeatability of the Glaucoma Hemifield Test in automated perimetry [29].

Analytical, diagnostic and therapeutic context of Perimetry


  1. Cotton-wool spots and retinal light sensitivity in diabetic retinopathy. Bek, T., Lund-Andersen, H. The British journal of ophthalmology. (1991) [Pubmed]
  2. Peripapillary fluorescein angiographic findings in primary open angle glaucoma. Yamazaki, S., Inoue, Y., Yoshikawa, K. The British journal of ophthalmology. (1996) [Pubmed]
  3. Topical dorzolamide increases pericentral visual function in age-related maculopathy: pilot study findings with short-wavelength automated perimetry. Remky, A., Weber, A., Arend, O., Sponsel, W.E. Acta ophthalmologica Scandinavica. (2005) [Pubmed]
  4. Static and kinetic perimetry results of krypton red laser treatment for macular edema complicating branch vein occlusion. Kremer, I., Hartman, B., Siegal, R., Ben-Sira, I. Annals of ophthalmology. (1990) [Pubmed]
  5. Occipital lobe infarction after open heart surgery. Smith, J.L., Cross, S.A. Journal of clinical neuro-ophthalmology. (1983) [Pubmed]
  6. Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual field defects. Kälviäinen, R., Nousiainen, I., Mäntyjärvi, M., Nikoskelainen, E., Partanen, J., Partanen, K., Riekkinen, P. Neurology (1999) [Pubmed]
  7. Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer. Wild, J.M., Robson, C.R., Jones, A.L., Cunliffe, I.A., Smith, P.E. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  8. Threshold and variability properties of matrix frequency-doubling technology and standard automated perimetry in glaucoma. Artes, P.H., Hutchison, D.M., Nicolela, M.T., LeBlanc, R.P., Chauhan, B.C. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  9. An early-onset autosomal dominant macular dystrophy (MCDR3) resembling North Carolina macular dystrophy maps to chromosome 5. Michaelides, M., Johnson, S., Tekriwal, A.K., Holder, G.E., Bellmann, C., Kinning, E., Woodruff, G., Trembath, R.C., Hunt, D.M., Moore, A.T. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  10. Effect of myopia on frequency-doubling perimetry. Ito, A., Kawabata, H., Fujimoto, N., Adachi-Usami, E. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  11. A long-term clinical trial of timolol therapy versus no treatment in the management of glaucoma suspects. Epstein, D.L., Krug, J.H., Hertzmark, E., Remis, L.L., Edelstein, D.J. Ophthalmology (1989) [Pubmed]
  12. A controlled study comparing visual function in patients treated with vigabatrin and tiagabine. Krauss, G.L., Johnson, M.A., Sheth, S., Miller, N.R. J. Neurol. Neurosurg. Psychiatr. (2003) [Pubmed]
  13. Deletion in the peripherin/RDS gene in two unrelated Sardinian families with autosomal dominant butterfly-shaped macular dystrophy. Fossarello, M., Bertini, C., Galantuomo, M.S., Cao, A., Serra, A., Pirastu, M. Arch. Ophthalmol. (1996) [Pubmed]
  14. Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy. Sponsel, W.E., Paris, G., Trigo, Y., Pena, M., Weber, A., Sanford, K., McKinnon, S. Am. J. Ophthalmol. (2002) [Pubmed]
  15. Short term effects of timolol in chronic glaucoma. A double blind study using computerized perimetry. Holmin, C., Krakau, C.E. Acta ophthalmologica. (1982) [Pubmed]
  16. Indocyanine green angiography in enlarged blind spot syndrome. Pece, A., Sadun, F., Trabucchi, G., Brancato, R. Am. J. Ophthalmol. (1998) [Pubmed]
  17. Malignant melanomas of the choroid that on fluorescein angiography and perimetry gave the impression of naevi. Hogeweg, M., Bos, P.J., Greve, E.L. Documenta ophthalmologica. Advances in ophthalmology. (1976) [Pubmed]
  18. Ocular hypertension and corneal thickness: a long-term prospective study. Results after two years. Brusini, P., Tosoni, C., Parisi, L., Rizzi, L. European journal of ophthalmology. (2005) [Pubmed]
  19. Localised scotomata and types of vascular occlusion in diabetic retinopathy. Bek, T. Acta ophthalmologica. (1991) [Pubmed]
  20. Mechanisms mediating visual detection in static perimetry. Harwerth, R.S., Smith, E.L., DeSantis, L. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  21. Effects of pupillary dilation on automated perimetry in glaucoma patients receiving pilocarpine. Rebolleda, G., Muñoz, F.J., Fernández Victorio, J.M., Pellicer, T., del Castillo, J.M. Ophthalmology (1992) [Pubmed]
  22. Modified grid laser photocoagulation for diabetic macular edema. The effect on the central visual field. Striph, G.G., Hart, W.M., Olk, R.J. Ophthalmology (1988) [Pubmed]
  23. Effects of pupillary dilation on automated perimetry in normal patients. Lindenmuth, K.A., Skuta, G.L., Rabbani, R., Musch, D.C., Bergstrom, T.J. Ophthalmology (1990) [Pubmed]
  24. Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population. The Rotterdam Study. Dielemans, I., de Jong, P.T., Stolk, R., Vingerling, J.R., Grobbee, D.E., Hofman, A. Ophthalmology (1996) [Pubmed]
  25. Fundus autofluorescence in carriers of X-linked recessive retinitis pigmentosa associated with mutations in RPGR, and correlation with electrophysiological and psychophysical data. Wegscheider, E., Preising, M.N., Lorenz, B. Graefes Arch. Clin. Exp. Ophthalmol. (2004) [Pubmed]
  26. Different clinical expressions in two families with Stargardt's macular dystrophy (STGD1). Eksandh, L., Ekström, U., Abrahamson, M., Bauer, B., Andréasson, S. Acta ophthalmologica Scandinavica. (2001) [Pubmed]
  27. The phenotype of normal tension glaucoma patients with and without OPA1 polymorphisms. Aung, T., Okada, K., Poinoosawmy, D., Membrey, L., Brice, G., Child, A.H., Bhattacharya, S.S., Lehmann, O.J., Garway-Heath, D.F., Hitchings, R.A. The British journal of ophthalmology. (2003) [Pubmed]
  28. Macular nerve fibers temporal to fovea may have a greater potential to recover function in patients with Leber's hereditary optic neuropathy. Mashima, Y., Sato, E.A., Ohde, H., Oguchi, Y. Jpn. J. Ophthalmol. (2002) [Pubmed]
  29. Repeatability of the Glaucoma Hemifield Test in automated perimetry. Katz, J., Quigley, H.A., Sommer, A. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  30. Human neural retinal transplantation. Humayun, M.S., de Juan, E., del Cerro, M., Dagnelie, G., Radner, W., Sadda, S.R., del Cerro, C. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  31. The spectrum of retinal phenotypes caused by mutations in the ABCA4 gene. Klevering, B.J., Deutman, A.F., Maugeri, A., Cremers, F.P., Hoyng, C.B. Graefes Arch. Clin. Exp. Ophthalmol. (2005) [Pubmed]
  32. Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy. Schuman, J.S., Wollstein, G., Farra, T., Hertzmark, E., Aydin, A., Fujimoto, J.G., Paunescu, L.A. Am. J. Ophthalmol. (2003) [Pubmed]
  33. The effect of topical antiglaucoma drugs on the results of high-pass resolution perimetry. Martin-Boglind, L.M., Graves, A., Wanger, P. Am. J. Ophthalmol. (1991) [Pubmed]
  34. Clinical importance of the electro-oculogram with special reference to the chloroquine retinopathy. van Lith, G.H., Mak, G.T., Wijnands, H. Bibliotheca ophthalmologica : supplementa ad ophthalmologica. (1976) [Pubmed]
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