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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Contrast Sensitivity

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Disease relevance of Contrast Sensitivity


Psychiatry related information on Contrast Sensitivity


High impact information on Contrast Sensitivity

  • These changes of contrast sensitivity function following treatment suggest that dopamine is a functional transmitter in the visual pathways [1].
  • CONCLUSIONS: In eyes with larger photopic pupil diameter, increases in spherical-like aberration dominantly affect contrast sensitivity, whereas in eyes with smaller pupil size, changes in coma-like aberration exert greater influence on visual performance [9].
  • PURPOSE: To determine whether asymptomatic 11778 LHON carriers demonstrated impairments in (1) chromatic red/green (R/G) and blue/yellow (B/Y) contrast sensitivity functions (CSF) and in (2) luminance contrast sensitivity functions in the spatial CSF (SCSF) and temporal CSF (TCSF) domains [10].
  • These VEP results are in general agreement with recent psychophysical studies of contrast sensitivity losses in patients with RP, and further they characterize contrast processing deficits in these patients at suprathreshold levels [11].
  • RESULTS: Five of the patients with RP who had Snellen visual acuities better than 20/25 had contrast sensitivity functions that were within the normal limits at all spatial frequencies for both testing paradigms [12].

Chemical compound and disease context of Contrast Sensitivity


Biological context of Contrast Sensitivity


Anatomical context of Contrast Sensitivity

  • Also following betaxolol treatment, contrast sensitivity improved significantly (p = .006), and a significant positive correlation was shown between change in contrast sensitivity and change in resistance index (r = .70; p = .015) of the ciliary arteries [22].
  • CONCLUSION: In virgin PCOS patients, when compared to transabdominal CBU, PIHI significantly improved the detection of ovarian follicles, especially in high BMI obese subjects, through increased contrast sensitivity for cystic structures and decreased intrafollicular artifactual echoes [23].
  • The ocular blood flow was measured by means of the ocular blood flow system, the optic nerve head blood flow with the continuous laser Doppler flowmeter (Riva), and contrast sensitivity using the MCT 8000 Multivision Contrast Tester [24].

Associations of Contrast Sensitivity with chemical compounds

  • We studied contrast sensitivity function in 10 parkinsonian patients before and after levodopa treatment [1].
  • These data also suggest that dynamic dioptric factors contribute to the magnitude of contrast sensitivity deficits in this patient population and indicate that the relationship between the individual tonus accommodation position and viewing distance is an important variable in CS testing [25].
  • Measurements of contrast sensitivity at four spatial frequencies (3, 6, 12, and 18 cycles/degree [c/deg]), macular capillary blood velocity (CBV), capillary density (PIA: perifoveal intercapillary area), foveal avascular zone (FAZ), and microaneurysm count were performed [26].
  • It is suggested that this effect is not caused by ethanol-induced changes in oculomotor mechanisms but may be caused by ethanol-induced decreases in contrast sensitivity [27].
  • We studied retinal contrast sensitivity, visual evoked EEG responses, and melatonin suppression by, and cerebral blood flow response to, full-spectrum artificial daylight [28].

Gene context of Contrast Sensitivity

  • In contrast sensitivity of the vg larvae to FUdR is observed [29].
  • The greater the amount of achieved myopia correction was, the more the changes in contrast sensitivity function and ocular higher-order aberrations were [30].
  • This method was based on a comparison of the measured change in contrast sensitivity (delta log (CSF)) of the eye and the calculated change in modulation transfer function of the cornea with undilated and dilated pupils [31].
  • Contrast sensitivity loss caused by forward scatter was assessed with a glare tester (Vistech MCT 8000) [32].
  • 2. Spatial contrast sensitivity was uniformly reduced compared with that of the normal trichromatic observer [33].

Analytical, diagnostic and therapeutic context of Contrast Sensitivity


  1. Effect of levodopa treatment on contrast sensitivity in Parkinson's disease. Bulens, C., Meerwaldt, J.D., Van der Wildt, G.J., Van Deursen, J.B. Ann. Neurol. (1987) [Pubmed]
  2. Selective broad-band spatial frequency loss in contrast sensitivity functions. Comparison with a model based on optical transfer functions. Bour, L.J., Apkarian, P. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  3. Subclinical visual involvement in multiple sclerosis: a study by MRI, VEPs, frequency-doubling perimetry, standard perimetry, and contrast sensitivity. Sisto, D., Trojano, M., Vetrugno, M., Trabucco, T., Iliceto, G., Sborgia, C. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  4. Suprathreshold responses of the visual system in normals and in demyelinating diseases. Medjbeur, S., Tulunay-Keesey, U. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  5. Contrast and glare sensitivity. Association with the type and severity of the cataract. Lasa, M.S., Datiles, M.B., Podgor, M.J., Magno, B.V. Ophthalmology (1992) [Pubmed]
  6. GABA-ergic control of visual perception in healthy volunteers: effects of midazolam, a benzodiazepine, on spatio-temporal contrast sensitivity. Blin, O., Mestre, D., Paut, O., Vercher, J.L., Audebert, C. British journal of clinical pharmacology. (1993) [Pubmed]
  7. Type 4 phosphodiesterase inhibition impairs detection of low odor concentrations in mice. Pho, V., Butman, M.L., Cherry, J.A. Behav. Brain Res. (2005) [Pubmed]
  8. Ophthalmic impairment at 7 years of age in children born very preterm. Cooke, R.W., Foulder-Hughes, L., Newsham, D., Clarke, D. Archives of disease in childhood. Fetal and neonatal edition. (2004) [Pubmed]
  9. Influence of pupil diameter on the relation between ocular higher-order aberration and contrast sensitivity after laser in situ keratomileusis. Oshika, T., Tokunaga, T., Samejima, T., Miyata, K., Kawana, K., Kaji, Y. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  10. Chromatic and luminance contrast sensitivities in asymptomatic carriers from a large Brazilian pedigree of 11778 Leber hereditary optic neuropathy. Ventura, D.F., Quiros, P., Carelli, V., Salomão, S.R., Gualtieri, M., Oliveira, A.G., Costa, M.F., Berezovsky, A., Sadun, F., de Negri, A.M., Sadun, A.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  11. Contrast response properties of magnocellular and parvocellular pathways in retinitis pigmentosa assessed by the visual evoked potential. Alexander, K.R., Rajagopalan, A.S., Seiple, W., Zemon, V.M., Fishman, G.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  12. Contrast sensitivity deficits in inferred magnocellular and parvocellular pathways in retinitis pigmentosa. Alexander, K.R., Barnes, C.S., Fishman, G.A., Pokorny, J., Smith, V.C. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  13. Baseline characteristics, natural history, and risk factors to progression in eyes with stage 2 macular holes. Results from a prospective randomized clinical trial. Vitrectomy for Macular Hole Study Group. Kim, J.W., Freeman, W.R., el-Haig, W., Maguire, A.M., Arevalo, J.F., Azen, S.P. Ophthalmology (1995) [Pubmed]
  14. Flicker sensitivity in treated ocular hypertension. Tytla, M.E., Trope, G.E., Buncic, J.R. Ophthalmology (1990) [Pubmed]
  15. Hyperoxia improves contrast sensitivity in early diabetic retinopathy. Harris, A., Arend, O., Danis, R.P., Evans, D., Wolf, S., Martin, B.J. The British journal of ophthalmology. (1996) [Pubmed]
  16. Optical coherence tomography can measure axonal loss in patients with ethambutol-induced optic neuropathy. Zoumalan, C.I., Agarwal, M., Sadun, A.A. Graefes Arch. Clin. Exp. Ophthalmol. (2005) [Pubmed]
  17. An evaluation of the effectiveness of intramuscular atropine or homatropine eyedrops in preventing the effects of physostigmine eyedrops on human vision. Kay, C.D., Morrison, J.D. Quarterly journal of experimental physiology (Cambridge, England) (1988) [Pubmed]
  18. Foveal vision function before and after fluorescein angiography. Friedman, N., Haegerstrom-Portnoy, G., Paul, O., Jampolsky, A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  19. Photoreceptor transplantation in retinitis pigmentosa: short-term follow-up. Berger, A.S., Tezel, T.H., Del Priore, L.V., Kaplan, H.J. Ophthalmology (2003) [Pubmed]
  20. Evidence for a potential role of glucagon during eye growth regulation in chicks. Feldkaemper, M.P., Schaeffel, F. Vis. Neurosci. (2002) [Pubmed]
  21. The effect of anthocyanosides in a multiple oral dose on night vision. Zadok, D., Levy, Y., Glovinsky, Y. Eye (London, England) (1999) [Pubmed]
  22. Primary open-angle glaucoma patients characterized by ocular vasospasm demonstrate a different ocular vascular response to timolol versus betaxolol. Evans, D.W., Harris, A., Cantor, L.B. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1999) [Pubmed]
  23. Transabdominal pulse inversion harmonic imaging improves assessment of ovarian morphology in virgin patients with PCOS: comparison with conventional B-mode sonography. Mahmutyazicioğlu, K., Tanriverdi, H.A., Ozdemir, H., Barut, A., Davşanci, H., Gündoğdu, S. European journal of radiology. (2005) [Pubmed]
  24. Visual function and perfusion of the optic nerve head after application of centrally acting calcium-channel blockers. Boehm, A.G., Breidenbach, K.A., Pillunat, L.E., Bernd, A.S., Mueller, M.F., Koeller, A.U. Graefes Arch. Clin. Exp. Ophthalmol. (2003) [Pubmed]
  25. Visual accommodation and sustained visual resolution in multiple sclerosis. Ogden, N.A., Raymond, J.E., Seland, T.P. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  26. Contrast sensitivity loss is coupled with capillary dropout in patients with diabetes. Arend, O., Remky, A., Evans, D., Stüber, R., Harris, A. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  27. Ingested ethanol and binocular rivalry. Donnelly, M., Miller, R.J. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  28. Seasonal affective disorder: response to light as measured by electroencephalogram, melatonin suppression, and cerebral blood flow. Murphy, D.G., Murphy, D.M., Abbas, M., Palazidou, E., Binnie, C., Arendt, J., Campos Costa, D., Checkley, S.A. The British journal of psychiatry : the journal of mental science. (1993) [Pubmed]
  29. Vestigial mutants of Drosophila melanogaster live better in the presence of aminopterin: increased level of dihydrofolate reductase in a mutant. Silber, J., Bazin, C., Le Menn, A. Mol. Gen. Genet. (1989) [Pubmed]
  30. Ocular higher-order aberrations and contrast sensitivity after conventional laser in situ keratomileusis. Yamane, N., Miyata, K., Samejima, T., Hiraoka, T., Kiuchi, T., Okamoto, F., Hirohara, Y., Mihashi, T., Oshika, T. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  31. Method for estimating the spheric aberration of the human crystalline lens in vivo. Tomlinson, A., Hemenger, R.P., Garriott, R. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  32. Intraocular light scattering in age-related cataracts. de Waard, P.W., IJspeert, J.K., van den Berg, T.J., de Jong, P.T. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  33. Human photopic vision with only short wavelength cones: post-receptoral properties. Hess, R.F., Mullen, K.T., Zrenner, E. J. Physiol. (Lond.) (1989) [Pubmed]
  34. Effect of levodopa on contrast sensitivity and scotomas in human amblyopia. Gottlob, I., Stangler-Zuschrott, E. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  35. Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity. Schreiber, J.S., Hudnell, H.K., Geller, A.M., House, D.E., Aldous, K.M., Force, M.S., Langguth, K., Prohonic, E.J., Parker, J.C. Environ. Health Perspect. (2002) [Pubmed]
  36. Corneal irregular astigmatism and contrast sensitivity after photorefractive keratectomy. Tomidokoro, A., Soya, K., Miyata, K., Armin, B., Tanaka, S., Amano, S., Oshika, T. Ophthalmology (2001) [Pubmed]
  37. Laser in situ keratomileusis for myopia and the contrast sensitivity function. Quesnel, N.M., Lovasik, J.V., Ferremi, C., Boileau, M., Ieraci, C. Journal of cataract and refractive surgery. (2004) [Pubmed]
  38. Pharmacological separation of mechanisms contributing to human contrast sensitivity. Smith, A.T., Baker-Short, C.M. Vis. Neurosci. (1993) [Pubmed]
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