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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.

Human metapneumovirus (hMPV)-infected BALB/c mice were treated with ribavirin (40 mg/kg of body weight twice a day intraperitoneally), corticosterone (0.2 mg/ml in water), or both modalities. Ribavirin significantly decreased both hMPV replication in lungs (by 5 log10) and global pulmonary inflammation on day 5 postinfection, whereas glucocorticoids reduced only alveolar and interstitial inflammation, compared to controls.[1]

References

  1. Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Hamelin, M.E., Prince, G.A., Boivin, G. Antimicrob. Agents Chemother. (2006) [Pubmed]
 
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