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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Pneumonia


Psychiatry related information on Pneumonia


High impact information on Pneumonia


Chemical compound and disease context of Pneumonia


Biological context of Pneumonia


Anatomical context of Pneumonia


Gene context of Pneumonia

  • OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation [28].
  • Treatment of mice with IL-12 at the time of a second antigen challenge also prevented airway hyperresponsiveness and significantly reduced numbers of BAL inflammatory cells, reflecting the ability of IL-12 to inhibit responses associated with ongoing antigen-induced pulmonary inflammation [29].
  • In contrast, Ptgs1-deficient mice had pancreatitis and pulmonary inflammation, which was as severe or, in some instances, more severe than in the wild-type mice [30].
  • Here we report that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung inflammation associated with airway remodeling and mucus hypersecretion [31].
  • These data suggest that a TM mutation that impairs APC generation results in uncontrolled lung inflammation during tuberculosis [32].

Analytical, diagnostic and therapeutic context of Pneumonia


  1. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Munger, J.S., Huang, X., Kawakatsu, H., Griffiths, M.J., Dalton, S.L., Wu, J., Pittet, J.F., Kaminski, N., Garat, C., Matthay, M.A., Rifkin, D.B., Sheppard, D. Cell (1999) [Pubmed]
  2. Controlled comparison of amikacin and gentamicin. Smith, C.R., Baughman, K.L., Edwards, C.Q., Rogers, J.F., Lietman, P.S. N. Engl. J. Med. (1977) [Pubmed]
  3. The importance of leukotrienes in airway inflammation in a mouse model of asthma. Henderson, W.R., Lewis, D.B., Albert, R.K., Zhang, Y., Lamm, W.J., Chiang, G.K., Jones, F., Eriksen, P., Tien, Y.T., Jonas, M., Chi, E.Y. J. Exp. Med. (1996) [Pubmed]
  4. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. Blackburn, M.R., Volmer, J.B., Thrasher, J.L., Zhong, H., Crosby, J.R., Lee, J.J., Kellems, R.E. J. Exp. Med. (2000) [Pubmed]
  5. Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis. Gudmundsson, G., Hunninghake, G.W. J. Clin. Invest. (1997) [Pubmed]
  6. Amiodarone-induced pneumonitis. Assessment of risk factors and possible risk reduction. Adams, G.D., Kehoe, R., Lesch, M., Glassroth, J. Chest (1988) [Pubmed]
  7. Adverse reactions to voriconazole. Boyd, A.E., Modi, S., Howard, S.J., Moore, C.B., Keevil, B.G., Denning, D.W. Clin. Infect. Dis. (2004) [Pubmed]
  8. Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone. Medina, I., Mills, J., Leoung, G., Hopewell, P.C., Lee, B., Modin, G., Benowitz, N., Wofsy, C.B. N. Engl. J. Med. (1990) [Pubmed]
  9. Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. Bitterman, P.B., Rennard, S.I., Keogh, B.A., Wewers, M.D., Adelberg, S., Crystal, R.G. N. Engl. J. Med. (1986) [Pubmed]
  10. Cyclophosphamide pneumonitis. Spector, J.I., Zimbler, H. N. Engl. J. Med. (1982) [Pubmed]
  11. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. Hughes, W.T., Kuhn, S., Chaudhary, S., Feldman, S., Verzosa, M., Aur, R.J., Pratt, C., George, S.L. N. Engl. J. Med. (1977) [Pubmed]
  12. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Akbari, O., Freeman, G.J., Meyer, E.H., Greenfield, E.A., Chang, T.T., Sharpe, A.H., Berry, G., DeKruyff, R.H., Umetsu, D.T. Nat. Med. (2002) [Pubmed]
  13. Reversibility of severe bleomycin-induced pneumonitis. Brown, W.G., Hasan, F.M., Barbee, R.A. JAMA (1978) [Pubmed]
  14. Naproxen and pneumonitis. Londino, A.V., Wolf, G.L., Calabro, J.J., Perrone, S.J. JAMA (1984) [Pubmed]
  15. Pneumonitis caused by metronidazole. Kristenson, M., Frydén, A. JAMA (1988) [Pubmed]
  16. The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity. McMillan, S.J., Bishop, B., Townsend, M.J., McKenzie, A.N., Lloyd, C.M. J. Exp. Med. (2002) [Pubmed]
  17. Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro. Marom, Z., Shelhamer, J., Berger, M., Frank, M., Kaliner, M. J. Exp. Med. (1985) [Pubmed]
  18. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler, T.W., Yamamoto, M., Petrache, I., Tuder, R.M., Biswal, S. J. Clin. Invest. (2004) [Pubmed]
  19. Oral tolerance in the absence of naturally occurring Tregs. Mucida, D., Kutchukhidze, N., Erazo, A., Russo, M., Lafaille, J.J., Curotto de Lafaille, M.A. J. Clin. Invest. (2005) [Pubmed]
  20. Effect of erythrocytes on alveolar macrophage cytostatic activity induced by bleomycin lung damage in rats. Huot, A.E., Gundel, R.M., Hacker, M.P. Cancer Res. (1990) [Pubmed]
  21. IL-12 modulates expression of hypersensitivity pneumonitis. Gudmundsson, G., Monick, M.M., Hunninghake, G.W. J. Immunol. (1998) [Pubmed]
  22. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. Blackwell, T.S., Blackwell, T.R., Holden, E.P., Christman, B.W., Christman, J.W. J. Immunol. (1996) [Pubmed]
  23. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Levy, B.D., De Sanctis, G.T., Devchand, P.R., Kim, E., Ackerman, K., Schmidt, B.A., Szczeklik, W., Drazen, J.M., Serhan, C.N. Nat. Med. (2002) [Pubmed]
  24. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Umetsu, S.E., Lee, W.L., McIntire, J.J., Downey, L., Sanjanwala, B., Akbari, O., Berry, G.J., Nagumo, H., Freeman, G.J., Umetsu, D.T., DeKruyff, R.H. Nat. Immunol. (2005) [Pubmed]
  25. Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. Huang, W.W., Garcia-Zepeda, E.A., Sauty, A., Oettgen, H.C., Rothenberg, M.E., Luster, A.D. J. Exp. Med. (1998) [Pubmed]
  26. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. Höpken, U.E., Lu, B., Gerard, N.P., Gerard, C. J. Exp. Med. (1997) [Pubmed]
  27. Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. Khalil, N., Whitman, C., Zuo, L., Danielpour, D., Greenberg, A. J. Clin. Invest. (1993) [Pubmed]
  28. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. Salek-Ardakani, S., Song, J., Halteman, B.S., Jember, A.G., Akiba, H., Yagita, H., Croft, M. J. Exp. Med. (2003) [Pubmed]
  29. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. Gavett, S.H., O'Hearn, D.J., Li, X., Huang, S.K., Finkelman, F.D., Wills-Karp, M. J. Exp. Med. (1995) [Pubmed]
  30. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Ethridge, R.T., Chung, D.H., Slogoff, M., Ehlers, R.A., Hellmich, M.R., Rajaraman, S., Saito, H., Uchida, T., Evers, B.M. Gastroenterology (2002) [Pubmed]
  31. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. Fainaru, O., Woolf, E., Lotem, J., Yarmus, M., Brenner, O., Goldenberg, D., Negreanu, V., Bernstein, Y., Levanon, D., Jung, S., Groner, Y. EMBO J. (2004) [Pubmed]
  32. A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis. Weijer, S., Wieland, C.W., Florquin, S., van der Poll, T. Blood (2005) [Pubmed]
  33. Bone marrow transplantation reveals an essential synergy between neuronal and hemopoietic cell neurokinin production in pulmonary inflammation. Chavolla-Calderón, M., Bayer, M.K., Fontán, J.J. J. Clin. Invest. (2003) [Pubmed]
  34. Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. Henderson, W.R., Chi, E.Y., Albert, R.K., Chu, S.J., Lamm, W.J., Rochon, Y., Jonas, M., Christie, P.E., Harlan, J.M. J. Clin. Invest. (1997) [Pubmed]
  35. Radiation pneumonitis: a possible lymphocyte-mediated hypersensitivity reaction. Roberts, C.M., Foulcher, E., Zaunders, J.J., Bryant, D.H., Freund, J., Cairns, D., Penny, R., Morgan, G.W., Breit, S.N. Ann. Intern. Med. (1993) [Pubmed]
  36. Serum levels of surfactant protein D are increased in mice with lung tumors. Zhang, F., Pao, W., Umphress, S.M., Jakowlew, S.B., Meyer, A.M., Dwyer-Nield, L.D., Nielsen, L.D., Takeda, K., Gelfand, E.W., Fisher, J.H., Zhang, L., Malkinson, A.M., Mason, R.J. Cancer Res. (2003) [Pubmed]
  37. Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide. Fan, J., Marshall, J.C., Jimenez, M., Shek, P.N., Zagorski, J., Rotstein, O.D. J. Immunol. (1998) [Pubmed]
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