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Isab, A.A. et al.

Isab, Wazeer,

Solid and solution NMR studies of the complexation of Ag(+) with the trans isomer of captopril: Biological activities of this high blood pressure drug along with its Ag(+) complex.

Complexation of Ag(+) with captopril, 1-[(2S)-3-mercapto-2-methylpropionyl]-l-proline, has been studied by (1)H and (13)C-NMR spectroscopy. The equilibrium constants for the trans to cis isomers of captopril bound to Ag(+) were measured by (1)H NMR spectroscopy. It is observed that the trans isomer of the drug binds more strongly to Ag(+) between pH 5 and 8, as shown by the broadening of the trans isomer's resonances in (13)C NMR spectra on complexation. A monodentate complexation of the trans captopril with Ag(+) via the thiol site is proposed based on the solid-state NMR and IR data. A superior antimicrobial activity is exhibited by the Cap-Ag(I) complex compared to captopril ligand itself against Heterotrotropic Plate Counts (HPC), Pseudomonas aeruginosa and Fecal streptococcus bacteria.[1]

References

Solid and solution NMR studies of the complexation of Ag(+) with the trans isomer of captopril: Biological activities of this high blood pressure drug along with its Ag(+) complex. Isab, A.A., Wazeer, M.I. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2006) [Pubmed]

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