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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Intranasal Administration of the Growth-Compromised HSV-2 Vector DeltaRR Prevents Kainate-Induced Seizures and Neuronal Loss in Rats and Mice.

Identification of targets and delivery platforms for gene therapy of neurodegenerative disorders is a clinical challenge. We describe a novel paradigm in which the neuroprotective gene is the herpes simplex virus type 2 (HSV-2) antiapoptotic gene ICP10PK and the vector is the growth-compromised HSV-2 mutant DeltaRR. DeltaRR is delivered intranasally. It is not toxic in rats and mice. ICP10PK is expressed in the hippocampus of the DeltaRR-treated animals for at least 42 days in the absence of virus replication and late virus gene expression. Its expression is regulated by an AP-1 amplification loop. Intranasally delivered DeltaRR prevents kainic acid-induced seizures, neuronal loss, and inflammation, in both rats and mice. The data suggest that DeltaRR is a promising therapeutic platform for neurodegenerative diseases.[1]

References

  1. Intranasal Administration of the Growth-Compromised HSV-2 Vector DeltaRR Prevents Kainate-Induced Seizures and Neuronal Loss in Rats and Mice. Laing, J.M., Gober, M.D., Golembewski, E.K., Thompson, S.M., Gyure, K.A., Yarowsky, P., Aurelian, L. Mol. Ther. (2006) [Pubmed]
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