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How Useful is ((123)I) b-CIT SPECT in the Diagnosis of Parkinson's Disease?

Because clinical features of parkinsonism can occur in other forms of parkinsonian syndromes in addition to Parkinson's disease, neuroimaging may have a role in determining true disease status. Iodine-123 ((123)I) (2b-carboxymethoxy-3b-[4-iodophenyl] tropane) or ((123)I) b-CIT is a recently developed diagnostic biomarker of Parkinson's disease that provides in vivo information about nigrostriatal degeneration. In clinical trials, b-CIT single photon emission computed tomography (SPECT) has been shown to be a highly sensitive diagnostic tool in differentiating clinically probable Parkinson's disease from normal subjects and essential tremor patients. As a tool for differentiating Parkinson's disease from atypical parkinsonian syndromes, ((123)I) b-CIT SPECT may have more limited use because of more extensive postsynaptic pathology in the latter. Differentiating among various parkinsonian syndromes may be improved by methodological refinements, a combined strategy of imaging presynaptic and postsynaptic sites, or by metabolic imaging.[1]

References

  1. How Useful is ((123)I) b-CIT SPECT in the Diagnosis of Parkinson's Disease? Bhidayasiri, R. Reviews in neurological diseases. (2006) [Pubmed]
 
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