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Chemical Compound Review

Iodine-123     iodane

Synonyms: AC1L2Y42, 123I, 15715-08-9, Iodine, isotope of mass 123, Iodine, isotope of mass 123, at.
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Disease relevance of hydrogen iodide


Psychiatry related information on hydrogen iodide


High impact information on hydrogen iodide


Chemical compound and disease context of hydrogen iodide


Biological context of hydrogen iodide

  • PURPOSE: To evaluate the feasibility of noninvasive imaging of estrogen receptors (ERs) in primary and metastatic breast cancer with the iodine-123-labeled ER-specific ligand cis-11beta-methoxy-17alpha-iodovinylestradiol-17beta (Z-[123I]MIVE) using conventional nuclear medicine techniques [21].
  • OBJECTIVES: We sought to prospectively compare the prognostic value of cardiac iodine-123 (I-123) metaiodobenzylguanidine (MIBG) imaging with that of heart rate variability (HRV) in patients with mild-to-moderate chronic heart failure (HF) [22].
  • Inhalation scintigraphy with iodine-123-labeled interferon gamma-1b: pulmonary deposition and dose escalation study in healthy volunteers [23].
  • The aim of our study was to examine the early kinetics of I*-FIAU and the possibility of utilising iodine-123-labelled FIAU for imaging of gene expression [24].
  • Iodine-123 orthoiodohippurate (OIH) scintigraphy and simultaneous para-aminohippurate clearance study for measuring standard ERPF were performed in three hospitals in 24 patients with normal or mildly impaired renal function [25].

Anatomical context of hydrogen iodide


Associations of hydrogen iodide with other chemical compounds


Gene context of hydrogen iodide


Analytical, diagnostic and therapeutic context of hydrogen iodide


  1. Differentiating Parkinson disease from multiple-system atrophy by measuring cardiac iodine-123 metaiodobenzylguanidine accumulation. Takatsu, H., Nagashima, K., Murase, M., Fujiwara, H., Nishida, H., Matsuo, H., Watanabe, S., Satomi, K. JAMA (2000) [Pubmed]
  2. Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours. Epenetos, A.A., Britton, K.E., Mather, S., Shepherd, J., Granowska, M., Taylor-Papadimitriou, J., Nimmon, C.C., Durbin, H., Hawkins, L.R., Malpas, J.S., Bodmer, W.F. Lancet (1982) [Pubmed]
  3. Contralateral thalamic perfusion in patients with reflex sympathetic dystrophy syndrome. Fukumoto, M., Ushida, T., Zinchuk, V.S., Yamamoto, H., Yoshida, S. Lancet (1999) [Pubmed]
  4. Therapeutic delivery of proteins to macrophages: implications for treatment of Gaucher's disease. Mistry, P.K., Wraight, E.P., Cox, T.M. Lancet (1996) [Pubmed]
  5. Clinical value of iodine-123-alpha-methyl-L-tyrosine single-photon emission tomography in the differential diagnosis of recurrent brain tumor in patients pretreated for glioma at follow-up. Samnick, S., Bader, J.B., Hellwig, D., Moringlane, J.R., Alexander, C., Romeike, B.F., Feiden, W., Kirsch, C.M. J. Clin. Oncol. (2002) [Pubmed]
  6. Diagnosis of Alzheimer's disease and multiple infarct dementia by tomographic imaging of iodine-123 IMP. Cohen, M.B., Graham, L.S., Lake, R., Metter, E.J., Fitten, J., Kulkarni, M.K., Sevrin, R., Yamada, L., Chang, C.C., Woodruff, N. J. Nucl. Med. (1986) [Pubmed]
  7. Iodine-123 iodoamphetamine brain scan in a patient with auditory hallucination. Matsuda, H., Gyobu, T., Ii, M., Hisada, K. J. Nucl. Med. (1988) [Pubmed]
  8. Iodine-123 HIPDM brain imaging findings in subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). Shih, W.J., Markesbery, W.R., Clark, D.B., Goldstein, S., Domstad, P.A., Coupal, J.J., Kung, H., DeKosky, S.T., DeLand, F.H. J. Nucl. Med. (1987) [Pubmed]
  9. The diagnosis of dementia with single photon emission computed tomography. Jagust, W.J., Budinger, T.F., Reed, B.R. Arch. Neurol. (1987) [Pubmed]
  10. Decreased iodine-123 IMP caudate nucleus uptake in patients with Huntington's disease. Nagel, J.S., Johnson, K.A., Ichise, M., English, R.J., Walshe, T.M., Morris, J.H., Holman, B.L. Clinical nuclear medicine. (1988) [Pubmed]
  11. Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. Virgolini, I., Raderer, M., Kurtaran, A., Angelberger, P., Banyai, S., Yang, Q., Li, S., Banyai, M., Pidlich, J., Niederle, B., Scheithauer, W., Valent, P. N. Engl. J. Med. (1994) [Pubmed]
  12. Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Begent, R.H., Verhaar, M.J., Chester, K.A., Casey, J.L., Green, A.J., Napier, M.P., Hope-Stone, L.D., Cushen, N., Keep, P.A., Johnson, C.J., Hawkins, R.E., Hilson, A.J., Robson, L. Nat. Med. (1996) [Pubmed]
  13. Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics. Tiihonen, J., Kuikka, J., Bergström, K., Hakola, P., Karhu, J., Ryynänen, O.P., Föhr, J. Nat. Med. (1995) [Pubmed]
  14. Preoperative imaging of parathyroid glands with technetium-99m-labelled sestamibi and iodine-123 subtraction scanning in secondary hyperparathyroidism. Hindié, E., Urenã, P., Jeanguillaume, C., Mellière, D., Berthelot, J.M., Menoyo-Calonge, V., Chiappini-Briffa, D., Janin, A., Galle, P. Lancet (1999) [Pubmed]
  15. Detection of activated lymphocytes in endocrine pancreas of BB/W rats by injection of 123I-interleukin-2: an early sign of type 1 diabetes. Signore, A., Parman, A., Pozzilli, P., Andreani, D., Beverley, P.C. Lancet (1987) [Pubmed]
  16. Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia. Joho, S., Asanoi, H., Takagawa, J., Kameyama, T., Hirai, T., Nozawa, T., Umeno, K., Shimizu, M., Seto, H., Inoue, H. J. Am. Coll. Cardiol. (2002) [Pubmed]
  17. In vitro and in vivo targeting properties of iodine-123- or iodine-131-labeled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model. Burvenich, I., Schoonooghe, S., Cornelissen, B., Blanckaert, P., Coene, E., Cuvelier, C., Mertens, N., Slegers, G. Clin. Cancer Res. (2005) [Pubmed]
  18. Imaging of dopamine transporters with iodine-123-beta-CIT and SPECT in Parkinson's disease. Asenbaum, S., Brücke, T., Pirker, W., Podreka, I., Angelberger, P., Wenger, S., Wöber, C., Müller, C., Deecke, L. J. Nucl. Med. (1997) [Pubmed]
  19. Diagnosis of recurrent glioma with SPECT and iodine-123-alpha-methyl tyrosine. Kuwert, T., Woesler, B., Morgenroth, C., Lerch, H., Schäfers, M., Palkovic, S., Matheja, P., Brandau, W., Wassmann, H., Schober, O. J. Nucl. Med. (1998) [Pubmed]
  20. Evaluation of a radiolabeled somatostatin analog (I-123 octreotide) in the detection and localization of carcinoid and islet cell tumors. Kvols, L.K., Brown, M.L., O'Connor, M.K., Hung, J.C., Hayostek, R.J., Reubi, J.C., Lamberts, S.W. Radiology. (1993) [Pubmed]
  21. Imaging of estrogen receptors in primary and metastatic breast cancer patients with iodine-123-labeled Z-MIVE. Rijks, L.J., Bakker, P.J., van Tienhoven, G., Noorduyn, L.A., Boer, G.J., Rietbroek, R.C., Taat, C.W., Janssen, A.G., Veenhof, C.H., van Royen, E.A. J. Clin. Oncol. (1997) [Pubmed]
  22. Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure: a prospective study. Yamada, T., Shimonagata, T., Fukunami, M., Kumagai, K., Ogita, H., Hirata, A., Asai, M., Makino, N., Kioka, H., Kusuoka, H., Hori, M., Hoki, N. J. Am. Coll. Cardiol. (2003) [Pubmed]
  23. Inhalation scintigraphy with iodine-123-labeled interferon gamma-1b: pulmonary deposition and dose escalation study in healthy volunteers. Virgolini, I., Kurtaran, A., Leimer, M., Smith-Jones, P., Agis, H., Angelberger, P., Kletter, K., Valent, P., Linkesch, W., Eichler, H.G. J. Nucl. Med. (1997) [Pubmed]
  24. In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU. Haubner, R., Avril, N., Hantzopoulos, P.A., Gansbacher, B., Schwaiger, M. European journal of nuclear medicine. (2000) [Pubmed]
  25. Evaluation of gamma camera-based measurement of individual kidney function using iodine-123 orthoiodohippurate. Oriuchi, N., Inoue, T., Hayashi, I., Mizuiri, S., Kosaka, N., Nishikawa, J., Sasaki, Y., Endo, K. European journal of nuclear medicine. (1996) [Pubmed]
  26. Bismuth 213-labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts. Sandmaier, B.M., Bethge, W.A., Wilbur, D.S., Hamlin, D.K., Santos, E.B., Brechbiel, M.W., Fisher, D.R., Storb, R. Blood (2002) [Pubmed]
  27. Thyroid uptake of 123I in a normal population. Hooper, P.L., Turner, J.R., Conway, M.J., Plymate, S.R. Arch. Intern. Med. (1980) [Pubmed]
  28. Iodine-123 metaiodobenzylguanidine cardiac imaging to identify and localize vasospastic angina without significant coronary artery narrowing. Sakata, K., Shirotani, M., Yoshida, H., Kurata, C. J. Am. Coll. Cardiol. (1997) [Pubmed]
  29. Effect of spironolactone on cardiac sympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy. Kasama, S., Toyama, T., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T., Kurabayashi, M. J. Am. Coll. Cardiol. (2003) [Pubmed]
  30. Localization of temporal lobe epileptic foci with iodine-123 iododexetimide cholinergic neuroreceptor single-photon emission computed tomography. Boundy, K.L., Rowe, C.C., Black, A.B., Kitchener, M.I., Barnden, L.R., Sebben, R., Kneebone, A., Kassiou, M., Katsifis, A., Lambrecht, R. Neurology (1996) [Pubmed]
  31. Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. Dong, Y., Fukuyama, H., Nabatame, H., Yamauchi, H., Shibasaki, H., Yonekura, Y. Stroke (1997) [Pubmed]
  32. Thallium-201 scintigraphy of the suppressed thyroid: an alternative for iodine-123 scanning after TSH stimulation. Corstens, F., Huysmans, D., Kloppenborg, P. J. Nucl. Med. (1988) [Pubmed]
  33. Cognitive correlates of regional cerebral blood flow in Alzheimer's disease. Eberling, J.L., Reed, B.R., Baker, M.G., Jagust, W.J. Arch. Neurol. (1993) [Pubmed]
  34. Thyroid uptake and imaging with iodine-123 at 4-5 hours: replacement of the 24-hour iodine-131 standard. Floyd, J.L., Rosen, P.R., Borchert, R.D., Jackson, D.E., Weiland, F.L. J. Nucl. Med. (1985) [Pubmed]
  35. Critical cerebral blood flow thresholds studied by SPECT using xenon-133 and iodine-123 iodoamphetamine. Nakano, S., Kinoshita, K., Jinnouchi, S., Hoshi, H., Watanabe, K. J. Nucl. Med. (1989) [Pubmed]
  36. Vasoactive intestinal peptide receptor scintigraphy in patients with pancreatic adenocarcinomas or neuroendocrine tumours. Hessenius, C., Bäder, M., Meinhold, H., Böhmig, M., Faiss, S., Reubi, J.C., Wiedenmann, B. European journal of nuclear medicine. (2000) [Pubmed]
  37. Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas. Becker, W., Marienhagen, J., Scheubel, R., Saptogino, A., Bakker, W.H., Breeman, W.A., Wolf, F. European journal of nuclear medicine. (1991) [Pubmed]
  38. Imaging of infection in rabbits with radioiodinated interleukin-1 (alpha and beta), its receptor antagonist and a chemotactic peptide: a comparative study. van der Laken, C.J., Boerman, O.C., Oyen, W.J., van de Ven, M.T., van der Meer, J.W., Corstens, F.H. European journal of nuclear medicine. (1998) [Pubmed]
  39. Lack of myocardial iodine-123 15-(p-iodiphenyl)-3-R,S-methylpentadecanoic acid (BMIPP) uptake and CD36 abnormality--CD36 deficiency and hypertrophic cardiomyopathy. Tanaka, T., Okamoto, F., Sohmiya, K., Kawamura, K. Jpn. Circ. J. (1997) [Pubmed]
  40. Iodine-123 meta-iodobenzylguanidine scintigraphy: a noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy. Schofer, J., Spielmann, R., Schuchert, A., Weber, K., Schlüter, M. J. Am. Coll. Cardiol. (1988) [Pubmed]
  41. Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter. Dingli, D., Peng, K.W., Harvey, M.E., Greipp, P.R., O'Connor, M.K., Cattaneo, R., Morris, J.C., Russell, S.J. Blood (2004) [Pubmed]
  42. Presymptomatic diagnosis of experimental Parkinsonism with 123I-PE2I SPECT. Prunier, C., Bézard, E., Montharu, J., Mantzarides, M., Besnard, J.C., Baulieu, J.L., Gross, C., Guilloteau, D., Chalon, S. Neuroimage (2003) [Pubmed]
  43. Cerebral perfusion imaging with iodine 123-labeled amines. Holman, B.L., Hill, T.C., Polak, J.F., Lee, R.G., Royal, H.D., O'Leary, D.H. Arch. Neurol. (1984) [Pubmed]
  44. Scintillation camera imaging with I-123. Graham, L.S., Zielinski, F.W. Radiology. (1979) [Pubmed]
  45. Radiation dosimetry from breast milk excretion of iodine-123. Blue, P.W., Dydek, G.J., Ghaed, N. J. Nucl. Med. (1987) [Pubmed]
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