The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Serby, M.D. et al.

Serby, Zhao, Szczepankiewicz, Kosogof, Xin, Liu, Liu, Nelson, Kaszubska, Falls, Schaefer, Bush, Shapiro, Droz, Knourek-Segel, Fey, Brune, Beno, Turner, Collins, Jacobson, Sham, Liu,

2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.

Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions with ghrelin antibody, peptidyl GHS-R antagonists, and antisense oligonucleosides resulted in weight loss and food intake decrease in rodents. Here we report the effects of GHS-R antagonists, some of which were potent, selective, and orally bioavailable. A structure-activity relationship study led to the discovery of 8a, which was effective in decreasing food intake and body weight in several acute rat studies.[1]

References

2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists. Serby, M.D., Zhao, H., Szczepankiewicz, B.G., Kosogof, C., Xin, Z., Liu, B., Liu, M., Nelson, L.T., Kaszubska, W., Falls, H.D., Schaefer, V., Bush, E.N., Shapiro, R., Droz, B.A., Knourek-Segel, V.E., Fey, T.A., Brune, M.E., Beno, D.W., Turner, T.M., Collins, C.A., Jacobson, P.B., Sham, H.L., Liu, G. J. Med. Chem. (2006) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg