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Chemical Compound Review

PubChem7056     pyrimidine-2,4-diamine

Synonyms: SureCN53016, ACMC-1BUYI, AG-K-61747, CHEMBL1233987, SureCN6961664, ...
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Gene context of NSC 30856

  • The current study examined the effects of etoprine, a highly lipophilic 2,4-diaminopyrimidine that is also a potent DHFR inhibitor, on the fertility of male mice at various dosages (0.1-50 mg/kg/day) for 55 days and male rats at 5 mg/kg/day for 65 days [11].


  1. Effects of coenzyme analogues on the binding of p-aminobenzoyl-L-glutamate and 2,4-diaminopyrimidine to Lactobacillus casei dihydrofolate reductase. Birdsall, B., Burgen, A.S., Roberts, G.C. Biochemistry (1980) [Pubmed]
  2. 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. Hocková, D., Holý, A., Masojídková, M., Andrei, G., Snoeck, R., De Clercq, E., Balzarini, J. J. Med. Chem. (2003) [Pubmed]
  3. Immunopotentiation by pyrimethamine in the mouse. Thong, Y.H., Ferrante, A. Clin. Exp. Immunol. (1980) [Pubmed]
  4. 2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists. Serby, M.D., Zhao, H., Szczepankiewicz, B.G., Kosogof, C., Xin, Z., Liu, B., Liu, M., Nelson, L.T., Kaszubska, W., Falls, H.D., Schaefer, V., Bush, E.N., Shapiro, R., Droz, B.A., Knourek-Segel, V.E., Fey, T.A., Brune, M.E., Beno, D.W., Turner, T.M., Collins, C.A., Jacobson, P.B., Sham, H.L., Liu, G. J. Med. Chem. (2006) [Pubmed]
  5. Efficacies of lipophilic inhibitors of dihydrofolate reductase against parasitic protozoa. Lau, H., Ferlan, J.T., Brophy, V.H., Rosowsky, A., Sibley, C.H. Antimicrob. Agents Chemother. (2001) [Pubmed]
  6. Molecular structures of 2,4-diaminopyrimidine antifolates with antineoplastic activity. Cody, V., Zakrzewski, S.F. J. Med. Chem. (1982) [Pubmed]
  7. Selective hydrolysis of 2,4-diaminopyrimidine systems: a theoretical and experimental insight into an old rule. Teixidó, J., Borrell, J.I., Colominas, C., Deupí, X., Matallana, J.L., Falcó, J.L., Martinez-Teipel, B. J. Org. Chem. (2001) [Pubmed]
  8. Mobility of the spin-labeled side chains of some novel antifolate inhibitors in their complexes with dihydrofolate reductase. Blakley, R.L., Piper, J.R., Maharaj, G., Appleman, J.R., Delcamp, T.J., Freisheim, J.H., Kulinski, R.F., Montgomery, J.A. Eur. J. Biochem. (1991) [Pubmed]
  9. Theoretical investigation of the molecular structure of the pi kappa DNA base pair. Florián, J., Leszczyński, J. J. Biomol. Struct. Dyn. (1995) [Pubmed]
  10. Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration. Liu, B., Liu, M., Xin, Z., Zhao, H., Serby, M.D., Kosogof, C., Nelson, L.T., Szczepankiewicz, B.G., Kaszubska, W., Schaefer, V.G., Falls, H.D., Lin, C.W., Collins, C.A., Sham, H.L., Liu, G. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  11. The contraceptive effects of etoprine on male mice and rats. Malik, N.S., Matlin, S.A., Fried, J., Pakyz, R.E., Consentino, M.J. J. Androl. (1995) [Pubmed]
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