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Patton, D.L. et al.

Dorothy L. Patton, Yvonne T. Cosgrove Sweeney, Kathy J. Agnew, Jennifer E. Balkus, Lorna K. Rabe, Sharon L. Hillier,

Development of a nonhuman primate model for Trichomonas vaginalis infection.

OBJECTIVE: Trichomoniasis, caused by Trichomonas vaginalis, is a prevalent sexually transmitted infection associated with increased risk of HIV infection. An animal model of T. vaginalis infection would enable scientists to further investigate trichomoniasis. STUDY DESIGN: Seven macaques (4 test vs. 3 control) were enrolled in a 2-week pilot study. Eight additional animals participated in a 2-arm (T. vaginalis vs. sham inoculated) crossover study lasting 5 weeks before treatment. In all, 12 Macaca nemestrina monkeys were challenged with a single intravaginal inoculation of 6.6 to 7.1 x 10(5) trichomonads (ATCC 50148). Vaginal culture (InPouch TV), colposcopy, microbiology, pH, and cervical cytokines were assessed at baseline, day 2, and weekly thereafter. RESULTS: Ten of 12 challenged animals tested positive for trichomoniasis for 2 weeks or longer. One animal tested positive on days 2 and 7 but negative thereafter. Only one animal was not infected. Oral metronidazole treatment (35 mg/kg per day for 3 days) resolved infection in all animals. Trichomoniasis infection did not lead to shifts in vaginal microbiology or pH. CONCLUSIONS: A single T. vaginalis inoculation results in persistent infection in the pigtailed macaque.[1]

References

Development of a nonhuman primate model for Trichomonas vaginalis infection. Patton, D.L., Sweeney, Y.T., Agnew, K.J., Balkus, J.E., Rabe, L.K., Hillier, S.L. Sex. Transm. Dis (2006) [Pubmed]

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