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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

HIV Infections

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Disease relevance of HIV Infections


Psychiatry related information on HIV Infections

  • CONCLUSIONS: Steadily increasing the methadone dosage in a harm reduction setting may be useful in supporting injecting drug users in the process of cessation of injecting and reducing the spread of HIV-infection [6].

High impact information on HIV Infections

  • HIV-infection status was known for 363 births (180 in the zidovudine group and 183 in the placebo group) [7].
  • The fact that prostaglandins are used clinically in the treatment of several diseases, suggests a potential use of cyclopentenone PGs in the treatment of HIV-infection [8].
  • PATIENTS AND METHODS: Twenty-six patients with TGCT and HIV-infection from the GICAT were retrospectively analyzed [9].
  • Different experimental approaches were used to prove or disprove the "TH1/TH2 switch theory" of HIV-infection [10].
  • These results demonstrate that elevated levels of IL-6 are associated with HIV-infection, and suggest that IL-6 over-production may contribute to the polyclonal B cell activation seen in AIDS and HIV infection [11].

Chemical compound and disease context of HIV Infections

  • The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine. Prometheus Study Group [12].
  • The results of this animal study indicate that abacavir would be a useful addition to a treatment regimen against HIV-infection within the brain [13].
  • In contrast, the serum DHEA concentrations were closely correlated with the stage of HIV-infection, being higher in the early stages (stages II and III or > 500 CD4) than in advanced stages (IV C or < 500 CD4)-in the latter being below those of HIV-negative men-or in controls (+40 to 100%, p < .01 to p < .001) [14].
  • CONCLUSION: Supplementation with whey proteins persistently increased plasma glutathione levels in patients with advanced HIV-infection [15].
  • Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment [16].

Biological context of HIV Infections


Anatomical context of HIV Infections

  • This review is intended to provide an update on the use of immune-based therapies, in particular structured treatment interruptions and cytokines, such as IL-2 and IFN-alpha, as potential stimulants of the immune system of patients with HIV-infections and to discuss risks and benefits of each alternative [20].

Gene context of HIV Infections


Analytical, diagnostic and therapeutic context of HIV Infections


  1. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Woitas, R.P., Ahlenstiel, G., Iwan, A., Rockstroh, J.K., Brackmann, H.H., Kupfer, B., Matz, B., Offergeld, R., Sauerbruch, T., Spengler, U. Gastroenterology (2002) [Pubmed]
  2. Complement receptor 1 (CD35) on human reticulocytes: normal expression in systemic lupus erythematosus and HIV-infected patients. Lach-Trifilieff, E., Marfurt, J., Schwarz, S., Sadallah, S., Schifferli, J.A. J. Immunol. (1999) [Pubmed]
  3. Beta-propiolactone UV inactivated clotting factor concentrate is the source of HIV-infection of 8 hemophilia B patients: confirmed. Kupfer, B., Oldenburg, J., Brackmann, H.H., Matz, B., Schneweis, K.E., Kaiser, R. Thromb. Haemost. (1995) [Pubmed]
  4. New developments in serologic screening of corneal donors for HIV-1 and hepatitis B virus infections. Pepose, J.S., Buerger, D.G., Paul, D.A., Quinn, T.C., Darragh, T.M., Donegan, E. Ophthalmology (1992) [Pubmed]
  5. Interferons in the persistence, pathogenesis, and treatment of HIV infection. Francis, M.L., Meltzer, M.S., Gendelman, H.E. AIDS Res. Hum. Retroviruses (1992) [Pubmed]
  6. Methadone maintenance and cessation of injecting drug use: results from the Amsterdam Cohort Study. Langendam, M.W., van Brussel, G.H., Coutinho, R.A., van Ameijden, E.J. Addiction (2000) [Pubmed]
  7. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Connor, E.M., Sperling, R.S., Gelber, R., Kiselev, P., Scott, G., O'Sullivan, M.J., VanDyke, R., Bey, M., Shearer, W., Jacobson, R.L. N. Engl. J. Med. (1994) [Pubmed]
  8. Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. Rozera, C., Carattoli, A., De Marco, A., Amici, C., Giorgi, C., Santoro, M.G. J. Clin. Invest. (1996) [Pubmed]
  9. Testicular germ cell tumors and human immunodeficiency virus infection: a report of 26 cases. Italian Cooperative Group on AIDS and Tumors. Bernardi, D., Salvioni, R., Vaccher, E., Repetto, L., Piersantelli, N., Marini, B., Talamini, R., Tirelli, U. J. Clin. Oncol. (1995) [Pubmed]
  10. Role of TH1/TH2 cytokines in HIV infection. Romagnani, S., Del Prete, G., Manetti, R., Ravina, A., Annunziato, F., De Carli, M., Mazzetti, M., Piccinni, M.P., D'Elios, M.M., Parronchi, P. Immunol. Rev. (1994) [Pubmed]
  11. Infection with HIV is associated with elevated IL-6 levels and production. Breen, E.C., Rezai, A.R., Nakajima, K., Beall, G.N., Mitsuyasu, R.T., Hirano, T., Kishimoto, T., Martinez-Maza, O. J. Immunol. (1990) [Pubmed]
  12. The effect of treatment intensification in HIV-infection: a study comparing treatment with ritonavir/saquinavir and ritonavir/saquinavir/stavudine. Prometheus Study Group. Gisolf, E.H., Jurriaans, S., Pelgrom, J., van Wanzeele, F., van der Ende, M.E., Brinkman, K., Borst, M.J., de Wolf, F., Japour, A.J., Danner, S.A. AIDS (2000) [Pubmed]
  13. Transport characteristics of the anti-human immunodeficiency virus nucleoside analog, abacavir, into brain and cerebrospinal fluid. Thomas, S.A., Bye, A., Segal, M.B. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  14. Serum cortisol and DHEA concentrations during HIV infection. Christeff, N., Gherbi, N., Mammes, O., Dalle, M.T., Gharakhanian, S., Lortholary, O., Melchior, J.C., Nunez, E.A. Psychoneuroendocrinology (1997) [Pubmed]
  15. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Micke, P., Beeh, K.M., Buhl, R. European journal of nutrition. (2002) [Pubmed]
  16. Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment. Folkers, K., Langsjoen, P., Nara, Y., Muratsu, K., Komorowski, J., Richardson, P.C., Smith, T.H. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  17. Cognitive and emotional deficits in early stages of HIV infection: an event-related potentials study. Bungener, C., Le Houezec, J.L., Pierson, A., Jouvent, R. Prog. Neuropsychopharmacol. Biol. Psychiatry (1996) [Pubmed]
  18. Endocrine testicular function in HIV-infected outpatients. Schürmeyer, T.H., Müller, V., von zur Mühlen, A., Schmidt, R.E. Eur. J. Med. Res. (1997) [Pubmed]
  19. HLA class II (DRB1, DQA1 and DQB1) allele and haplotype frequencies among HIV-infection discordant Thai couples. Bejrachandra, S., Kitayaporn, D., Kaewkungwal, J., Piya-Anant, M., Permpikul, P., Sirikong, M., Siriboonrit, U., Chandanayingyong, D. Asian Pac. J. Allergy Immunol. (2004) [Pubmed]
  20. Cytokine therapy or structured treatment interruptions in HIV infection: which is best? Parienti, J.J. Expert opinion on pharmacotherapy. (2002) [Pubmed]
  21. Matrix metalloproteinases-1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection. Mellanen, L., Ingman, T., Lähdevirta, J., Lauhio, A., Ainamo, A., Konttinen, Y.T., Sukura, A., Salo, T., Sorsa, T. Oral diseases. (1996) [Pubmed]
  22. T(H)1 to T(H)2 shift of cytokines in peripheral blood of HIV-infected patients is detectable by reverse transcriptase polymerase chain reaction but not by enzyme-linked immunosorbent assay under nonstimulated conditions. Altfeld, M., Addo, M.M., Kreuzer, K.A., Rockstroh, J.K., Dumoulin, F.L., Schliefer, K., Leifeld, L., Sauerbruch, T., Spengler, U. J. Acquir. Immune Defic. Syndr. (2000) [Pubmed]
  23. Effect of 1,25-dihydroxyvitamin D3 and its analogs on human immunodeficiency virus infection in monocytes/macrophages. Kizaki, M., Ikeda, Y., Simon, K.J., Nanjo, M., Koeffler, H.P. Leukemia (1993) [Pubmed]
  24. Comparison between subcutaneous and intravenous interleukin-2 treatment in HIV disease. Witzke, O., Winterhagen, T., Reinhardt, W., Heemann, U., Grosse-Wilde, H., Kreuzfelder, E., Roggendorf, M., Philipp, T. J. Intern. Med. (1998) [Pubmed]
  25. Regulation of interleukin-18 by THP-1 monocytoid cells stimulated with HIV-1 and Nef viral protein. Pugliese, A., Vidotto, V., Beltramo, T., Torre, D. Eur. Cytokine Netw. (2005) [Pubmed]
  26. Effect of placental malaria and HIV infection on the antibody responses to Plasmodium falciparum in infants. Ned, R.M., Price, A.E., Crawford, S.B., Ayisi, J.G., van Eijk, A.M., Otieno, J.A., Nahlen, B.L., Steketee, R.W., Slutsker, L., Shi, Y.P., Lanar, D.E., Udhayakumar, V. J. Infect. Dis. (2008) [Pubmed]
  27. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. Dunham, R.M., Cervasi, B., Brenchley, J.M., Albrecht, H., Weintrob, A., Sumpter, B., Engram, J., Gordon, S., Klatt, N.R., Frank, I., Sodora, D.L., Douek, D.C., Paiardini, M., Silvestri, G. J. Immunol. (2008) [Pubmed]
  28. Chronic pentamidine aerosol prophylaxis does not induce QT prolongation. Thalhammer, C., Bogner, J.R., Lohmöller, G. The Clinical investigator. (1993) [Pubmed]
  29. Quantitative analysis of CD6, CD4 and CD8 cell surface molecules compared to the absolute numbers of CD6+, CD4+ and CD8+ T-cells in peripheral blood in patients with HIV-infection. Gruber, R., Endl, J., Fröschl, M., Rieber, E.P., Ziegler-Heitbrock, H.W., Riethmüller, G. Journal of clinical & laboratory immunology. (1991) [Pubmed]
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