Disease relevance of Macaca nemestrina

• In order to investigate the effects of the calcium entry blocker lidoflazine on neurologic outcome in primates following an episode of global brain ischemia, 12 pigtail monkeys (Macaca nemestrina) were subjected to 17 min of complete cerebral ischemia, followed by 48 h of intensive care treatment and daily neurologic evaluations for 96 h [1].
• Groups of four pigtail macaques were immunized four times over a 25-week span with either a recombinant Semliki Forest virus expressing the SIV-PBj14 Env gp160 (SFV-SIVgp160) or purified recombinant SIV-PBj14 gp120 (rgp120) in SBN-1 adjuvant [2].
• NM-3rN, which carries HIV-1 vpr and SIVmac nef, was inoculated intravenously into three rhesus monkeys, three cynomolgus monkeys and two pig-tailed monkeys [3].
• Cholesterol-fed male pigtail monkeys were used to determine the metabolic mechanism of dietary hypercholesterolemia [4].

Psychiatry related information on Macaca nemestrina

• In this pilot study the oral administration of melatonin to two Pigtail macaques (Macaca Nemestrina) at different times of the day significantly decreased motor activity and promoted earlier sleep onset, as measured actigraphically [5].

High impact information on Macaca nemestrina

• Sustained antiestrogenic effects, following a single parenteral dose of ICI 182,780 in oil suspension, were apparent in both rats and pigtail monkeys [6].
• Using ovariectomized pigtail macaques (Macaca nemestrina), we evaluated the potential for MPA to antagonize estradiol (E2) effects on female sociosexual behavior [7].
• Mhc-DRB genes of the pigtail macaque (Macaca nemestrina): implications for the evolution of human DRB genes [8].
• In pigtail macaques, hGH was also a more potent stimulant of alpha-lactalbumin production than oPRL, but the differences wer not as great as in rhesus monkeys. alpha-Lactalbumin in medium was higher in hGH-containing dishes than in those containing oPRL in over 85% of the cases [9].
• Healthy male pigtail monkeys (Macaca nemestrina) were procured at the age of 6-9 months, and fed either a 20 percent casein diet or a diet containing 2 percent casein as the sole source of protein [10].

Chemical compound and disease context of Macaca nemestrina

• The authors investigated the value of high-dose thiopental (TH) therapy after 16-min complete global brain ischemia (GBI) in three groups of pigtailed monkeys, using a neck cuff model of GBI with 96 h intensive care postischemia (PI) [11].

Biological context of Macaca nemestrina

• Daily measurement of serum luteinizing hormone, estradiol-17beta, and progesterone were made during the menstrual cycle in nine pigtail macaques (Macaca nemestrina) [12].

Anatomical context of Macaca nemestrina

• Two intratubal devices, one covered with a flock made from ethylene vinyl acetate and the other constructed of titanium-aluminum-vanadium alloy with an etched surface were evaluated after being placed in the Fallopian tubes of pigtail monkeys [13].
• Titanium implants were placed surgically into the maxillary, zygomatic, frontal, and occipital bones of four pigtail monkeys [14].

Associations of Macaca nemestrina with chemical compounds

• In three male pigtail macaques, motoneurons were labeled by retrograde transport of cholera toxin-horseradish peroxidase that was injected into TS muscles bilaterally and visualized with tetramethylbenzidine stabilized with diaminobenzidine [15].
• Effect of carbidopa on the metabolism of L-dopa in the pigtail monkey [16].
• To compare the local and systemic effects of chronic intracavernous injection of papaverine, prostaglandin E1, and saline on erectile tissue, eight pigtail monkeys underwent 75 injections over a nine-month period [17].
• The results showed both primate species have a well-developed olfactory sensitivity for aliphatic ketones, and pigtail macaques generally perform better than squirrel monkeys in detecting members of this class of odorants [18].
• Didanosine but not high doses of hydroxyurea rescue pigtail macaque from a lethal dose of SIV(smmpbj14) [19].

Gene context of Macaca nemestrina

• Studies were undertaken on the heat denaturation and proteolytic degradation by alpha-chymotrypsin of the normal red cell carbonic anhydrase isozyme, CA II, and two electrophoretic variants of carbonic anhydrase I, CA Ia and CA Ib, of the pigtail macaque [20].
• Glutathione peroxidase activity of the olive baboon lens increased steadily with age while that of the pigtail monkey increased during the first 6-8 years and then plateaued [21].
• The activities of gamma-glutamylcysteine synthetase and glutathione synthetase, the two enzymes required for glutathione synthesis, were determined as a function of age in lenses of three species of Old World higher primates: orangutan, pigtail monkey and olive baboon [22].
• We sequenced the flanking regions of the C4-CYP21 modules and the intermodular regions of the chimpanzee, gorilla, and orangutan, as well as the intermodular region of an Old World monkey, the pigtail macaque [23].
• Deletion of the nef gene abrogates the ability of SIV smmPBj to induce acutely lethal disease in pigtail macaques [24].

References