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Chemical Compound Review

Cordipin     dimethyl2,6-dimethyl-4-(2- nitrophenyl)-1...

Synonyms: Corinfar, Korinfar, Nifangin, Cordipine, Fenigidin, ...
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Disease relevance of Adalat


Psychiatry related information on Adalat


High impact information on Adalat


Chemical compound and disease context of Adalat

  • To assess whether vasodilator therapy reduces or delays the need for valve replacement, we randomly assigned 143 asymptomatic patients with isolated, severe aortic regurgitation and normal left ventricular systolic function to receive either nifedipine (20 mg twice daily, 69 patients) or digoxin (0.25 mg daily, 74 patients) [11].
  • Ventricular myocytes exhibit a nifedipine-sensitive inward calcium current (ICa) and contracture when they are voltage clamped from -40 to 0 millivolt in the presence of caffeine and in the absence of extracellular sodium [13].
  • Combined nitrate/beta-blocker/nifedipine therapy is commonly used to treat refractory angina pectoris [14].
  • The present study examined whether a pre- or postischemic infusion of verapamil (V) or a postischemic infusion of nifedipine (N), drugs which block calcium (Ca++) influx across plasma membranes, provides protection against ischemic acute renal failure (ARF) in dogs [15].
  • INSIGHT and NORDIL. International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment. Nordic Diltiazem Study [16].

Biological context of Adalat


Anatomical context of Adalat


Associations of Adalat with other chemical compounds

  • To determine whether abnormalities of myocardial perfusion in this disorder are potentially reversible, we evaluated the effect of the coronary vasodilator nifedipine on myocardial perfusion assessed by thallium-201 scanning in 20 patients [26].
  • The L-type Ca2+ channel blockers verapamil and nifedipine inhibited NE-stimulated incorporation of [3H]leucine in myocytes and [3H]thymidine in fibroblasts, and these effects were not additive with those of ANP, SNAP, or 8-bromo-cGMP [27].
  • Increased expression of the alpha1D receptor mRNA was inhibited by the receptor tyrosine kinase inhibitor genistein and the PI 3-kinase inhibitor wortmannin but was not inhibited by protein kinase C inhibitor H7 or the L-type calcium channel blocker nifedipine [28].
  • To test the hypothesis that Nifedipine alters CHOL metabolism, thereby decreasing free and esterified CHOL accumulation in smooth muscle cells (SMC), we cultured arterial SMC from rabbits fed a normal or egg-supplemented diet for 6 mo [29].
  • Total exercise duration was longer on atenolol plus mononitrate than on atenolol alone (mean difference 46 [95% confidence interval 18-88] s; p = 0.005), atenolol plus nifedipine (36 [2-71] s; p = 0.04), or triple therapy (28 [6-61] s; not significant) [30].

Gene context of Adalat


Analytical, diagnostic and therapeutic context of Adalat


  1. Myocardial infarction during nifedipine therapy for preterm labor. Oei, S.G., Oei, S.K., Brölmann, H.A. N. Engl. J. Med. (1999) [Pubmed]
  2. Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. Antman, E., Muller, J., Goldberg, S., MacAlpin, R., Rubenfire, M., Tabatznik, B., Liang, C.S., Heupler, F., Achuff, S., Reichek, N., Geltman, E., Kerin, N.Z., Neff, R.K., Braunwald, E. N. Engl. J. Med. (1980) [Pubmed]
  3. Nifedipine in unstable angina: a double-blind, randomized trial. Gerstenblith, G., Ouyang, P., Achuff, S.C., Bulkley, B.H., Becker, L.C., Mellits, E.D., Baughman, K.L., Weiss, J.L., Flaherty, J.T., Kallman, C.H., Llewellyn, M., Weisfeldt, M.L. N. Engl. J. Med. (1982) [Pubmed]
  4. Nifedipine for relief of esophageal chest pain. Cargill, G., Theodore, C., Paolaggi, J.A. N. Engl. J. Med. (1982) [Pubmed]
  5. Nifedipine in severe aortic regurgitation. Klein, L.J., Reichert, C.L., Arnold, A.E. N. Engl. J. Med. (1995) [Pubmed]
  6. Effect of nifedipine on sphincter of Oddi motor activity: studies in healthy volunteers and patients with biliary dyskinesia. Guelrud, M., Mendoza, S., Rossiter, G., Ramirez, L., Barkin, J. Gastroenterology (1988) [Pubmed]
  7. Shared Capgras syndrome and nifedipine. Franklin, G.S., Brown, J.W., Freedman, M.L. Lancet (1982) [Pubmed]
  8. Atenolol compared with nifedipine: effect on cognitive function and mood in elderly hypertensive patients. Skinner, M.H., Futterman, A., Morrissette, D., Thompson, L.W., Hoffman, B.B., Blaschke, T.F. Ann. Intern. Med. (1992) [Pubmed]
  9. Once-daily therapy for angina pectoris with nifedipine gastrointestinal therapeutic system. Dosing and clinical efficacy. Vetrovec, G.W. Am. J. Med. (1989) [Pubmed]
  10. The effect of electroconvulsive shock and nifedipine on spatial learning and memory in rats. Popik, P., Mamczarz, J., Vetulani, J. Biol. Psychiatry (1994) [Pubmed]
  11. Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. Scognamiglio, R., Rahimtoola, S.H., Fasoli, G., Nistri, S., Dalla Volta, S. N. Engl. J. Med. (1994) [Pubmed]
  12. Death in a patient with primary pulmonary hypertension after 20 mg of nifedipine. Partanen, J., Nieminen, M.S., Luomanmäki, K. N. Engl. J. Med. (1993) [Pubmed]
  13. The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Bridge, J.H., Smolley, J.R., Spitzer, K.W. Science (1990) [Pubmed]
  14. Nifedipine-induced hypotension and myocardial ischemia in refractory angina pectoris. Boden, W.E., Korr, K.S., Bough, E.W. JAMA (1985) [Pubmed]
  15. Protective effect of intrarenal calcium membrane blockers before or after renal ischemia. Functional, morphological, and mitochondrial studies. Burke, T.J., Arnold, P.E., Gordon, J.A., Bulger, R.E., Dobyan, D.C., Schrier, R.W. J. Clin. Invest. (1984) [Pubmed]
  16. INSIGHT and NORDIL. International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment. Nordic Diltiazem Study. García-López, F.J., de Alvaro, F. Lancet (2000) [Pubmed]
  17. Inhibition of hypoxic pulmonary vasoconstriction by nifedipine. Simonneau, G., Escourrou, P., Duroux, P., Lockhart, A. N. Engl. J. Med. (1981) [Pubmed]
  18. Gingival sequestration of nifedipine in nifedipine-induced gingival overgrowth. Ellis, J.S., Seymour, R.A., Monkman, S.C., Idle, J.R. Lancet (1992) [Pubmed]
  19. Interaction of citrus juices with felodipine and nifedipine. Bailey, D.G., Spence, J.D., Munoz, C., Arnold, J.M. Lancet (1991) [Pubmed]
  20. Nifedipine inhibits deep-inspiration-induced bronchoconstriction in asthmatics. Rolla, G., Bucca, C., Polizzi, S., Maina, A., Giachino, O., Salvini, P. Lancet (1982) [Pubmed]
  21. Nifedipine for coronary-artery spasm after revascularization. Lewis, B.H., Muller, J.E., Rutherford, J., Mudge, G.H., Collins, J.J. N. Engl. J. Med. (1982) [Pubmed]
  22. Prevention of high-altitude pulmonary edema by nifedipine. Bärtsch, P., Maggiorini, M., Ritter, M., Noti, C., Vock, P., Oelz, O. N. Engl. J. Med. (1991) [Pubmed]
  23. Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels. Schramm, M., Thomas, G., Towart, R., Franckowiak, G. Nature (1983) [Pubmed]
  24. Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens. Blakeley, A.G., Brown, D.A., Cunnane, T.C., French, A.M., McGrath, J.C., Scott, N.C. Nature (1981) [Pubmed]
  25. Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes. Dascal, N., Snutch, T.P., Lübbert, H., Davidson, N., Lester, H.A. Science (1986) [Pubmed]
  26. Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis. Kahan, A., Devaux, J.Y., Amor, B., Menkès, C.J., Weber, S., Nitenberg, A., Venot, A., Guérin, F., Degeorges, M., Roucayrol, J.C. N. Engl. J. Med. (1986) [Pubmed]
  27. Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. Calderone, A., Thaik, C.M., Takahashi, N., Chang, D.L., Colucci, W.S. J. Clin. Invest. (1998) [Pubmed]
  28. Insulin and insulin-like growth factor I differentially induce alpha1-adrenergic receptor subtype expression in rat vascular smooth muscle cells. Hu, Z.W., Shi, X.Y., Hoffman, B.B. J. Clin. Invest. (1996) [Pubmed]
  29. Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells. A possible mechanism for its antiatherogenic effect. Etingin, O.R., Hajjar, D.P. J. Clin. Invest. (1985) [Pubmed]
  30. Efficacy of nifedipine and isosorbide mononitrate in combination with atenolol in stable angina. Akhras, F., Jackson, G. Lancet (1991) [Pubmed]
  31. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Wandel, C., Kim, R.B., Kajiji, S., Guengerich, P., Wilkinson, G.R., Wood, A.J. Cancer Res. (1999) [Pubmed]
  32. Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. Paine, M.J., McLaughlin, L.A., Flanagan, J.U., Kemp, C.A., Sutcliffe, M.J., Roberts, G.C., Wolf, C.R. J. Biol. Chem. (2003) [Pubmed]
  33. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Schuetz, E.G., Beck, W.T., Schuetz, J.D. Mol. Pharmacol. (1996) [Pubmed]
  34. Nifedipine increases cytochrome P4502C expression and endothelium-derived hyperpolarizing factor-mediated responses in coronary arteries. Fisslthaler, B., Hinsch, N., Chataigneau, T., Popp, R., Kiss, L., Busse, R., Fleming, I. Hypertension (2000) [Pubmed]
  35. Effects of nifedipine in achalasia and in patients with high-amplitude peristaltic esophageal contractions. Traube, M., Hongo, M., Magyar, L., McCallum, R.W. JAMA (1984) [Pubmed]
  36. Controlled trial of nifedipine in the treatment of Raynaud's phenomenon. Smith, C.D., McKendry, R.J. Lancet (1982) [Pubmed]
  37. Effect of nifedipine in metastatic colon cancer with DNA mismatch repair gene defect. Yang, J.L., Friedlander, M.L. Lancet (2001) [Pubmed]
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