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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Increased TGF-alpha and EGF Receptor mRNA Expression in Response to Neonatal Unilateral Partial Ureter Obstruction in Rats.

Aim: To evaluate the potential role of members of the epidermal growth factor (EGF) family in altered renal growth caused by partial ureteral obstruction in the developing obstructed and non-obstructed kidneys. Methods: During anesthesia either the upper fourth (n = 6-7) or the upper two-thirds of the left ureter (n = 6-7) were embedded into the psoas muscle in newborn rats resulting in mild or severe partial unilateral obstruction, respectively, which was maintained during the following 24 weeks. Sham-operated control rats were prepared in parallel (n = 6-7). Real time PCR assays were used to quantify mRNA encoding EGF, TGF-alpha, HB-EGF and EGF receptor. The expression of ribosomal RNA was determined to relate the specific mRNA expression of members of the EGF system. Results: Relative expression of TGF-alpha and EGF receptor mRNA levels were elevated significantly both in the severe and mild obstructed kidney compared with the contralateral or sham-operated kidneys after 24 weeks of obstruction. However, the expression of neither EGF nor HB-EGF was changed after obstruction. Conclusion: The increased expression of TGF-alpha and its receptor in the obstructed kidney might be related to a cell-survival function in the affected cells possibly by protecting them from entering apoptosis. Copyright (c) 2006 S. Karger AG, Basel.[1]

References

  1. Increased TGF-alpha and EGF Receptor mRNA Expression in Response to Neonatal Unilateral Partial Ureter Obstruction in Rats. Bor, M.V., Shi, Y., Sorensen, B.S., Wen, J.G., Frokiaer, J., Djurhuus, J.C., Nexo, E. Nephron Exp. Nephrol. (2006) [Pubmed]
 
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