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MeSH Review

Ureteral Obstruction

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Disease relevance of Ureteral Obstruction


High impact information on Ureteral Obstruction

  • Tubular epithelial cell proliferation and apoptosis was also increased in p27-/- mice following ureteral obstruction. p27Kip1 may have a general role in protecting cells and tissues from inflammatory injury [6].
  • Unmasking of thromboxane A2 synthesis by ureteral obstruction in the rabbit kidney [7].
  • Mice lacking tPA developed less morphological injury and displayed a reduced deposition of interstitial collagen III and fibronectin as well as total tissue collagen in the kidneys after sustained ureteral obstruction, when compared with their wild-type counterparts [8].
  • Ureteral obstruction causes impaired salt wastage and K+ secretion in the distal nephron segments, including the cortical collecting duct (CCD) [9].
  • We conclude that ureteral obstruction reduces the amounts of both luminal Na-K-2Cl cotransporter and basolateral Na-K-ATPase in mTAL of obstructed kidney and that these reductions contribute to the salt wasting observed after release of obstruction [10].

Chemical compound and disease context of Ureteral Obstruction


Biological context of Ureteral Obstruction


Anatomical context of Ureteral Obstruction


Gene context of Ureteral Obstruction


Analytical, diagnostic and therapeutic context of Ureteral Obstruction


  1. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. Sato, M., Muragaki, Y., Saika, S., Roberts, A.B., Ooshima, A. J. Clin. Invest. (2003) [Pubmed]
  2. Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction. Park, K.M., Kramers, C., Vayssier-Taussat, M., Chen, A., Bonventre, J.V. J. Biol. Chem. (2002) [Pubmed]
  3. Amyloid deposition in serosal membranes. Its occurrence with cardiac tamponade, bilateral ureteral obstruction, and gastrointestinal bleeding. Weinrauch, L.A., Desautels, R.E., Christlieb, A.R., Kaldany, A., D'Elia, J.A. Arch. Intern. Med. (1984) [Pubmed]
  4. Bilateral ureteral obstruction due to uric acid stones in association with immune hemolytic anemia. Schroder, L.E., Vilter, R.W. Arch. Intern. Med. (1983) [Pubmed]
  5. Renal tubulointerstitial injury from ureteral obstruction in the neonatal rat is attenuated by IGF-1. Chevalier, R.L., Goyal, S., Kim, A., Chang, A.Y., Landau, D., LeRoith, D. Kidney Int. (2000) [Pubmed]
  6. The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury. Ophascharoensuk, V., Fero, M.L., Hughes, J., Roberts, J.M., Shankland, S.J. Nat. Med. (1998) [Pubmed]
  7. Unmasking of thromboxane A2 synthesis by ureteral obstruction in the rabbit kidney. Morrison, A.R., Nishikawa, K., Needleman, P. Nature (1977) [Pubmed]
  8. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. Yang, J., Shultz, R.W., Mars, W.M., Wegner, R.E., Li, Y., Dai, C., Nejak, K., Liu, Y. J. Clin. Invest. (2002) [Pubmed]
  9. Electrical properties of the rabbit cortical collecting duct from obstructed kidneys after unilateral ureteral obstruction. Effects of renal decapsulation. Muto, S., Asano, Y. J. Clin. Invest. (1994) [Pubmed]
  10. Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Hwang, S.J., Haas, M., Harris, H.W., Silva, P., Yalla, S., Sullivan, M.R., Otuechere, G., Kashgarian, M., Zeidel, M.L. J. Clin. Invest. (1993) [Pubmed]
  11. Effects of acute bilateral ureteral obstruction on deep nephron and terminal collecting duct function in the young rat. Buerkert, J., Head, M., Klahr, S. J. Clin. Invest. (1977) [Pubmed]
  12. Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney. Nishikawa, K., Morrison, A., Needleman, P. J. Clin. Invest. (1977) [Pubmed]
  13. Cross-circulation study of natriuretic factors in postobstructive diuresis. Wilson, D.R., Honrath, U. J. Clin. Invest. (1976) [Pubmed]
  14. Mesangial function in ureteral obstruction in the rat. Blockade of the efferent limb. Raij, L., Keane, W.F., Osswald, H., Michael, A. J. Clin. Invest. (1979) [Pubmed]
  15. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney. Higuchi, T., Orita, T., Nakanishi, S., Katsuya, K., Watanabe, H., Yamasaki, Y., Waga, I., Nanayama, T., Yamamoto, Y., Munger, W., Sun, H.W., Falk, R.J., Jennette, J.C., Alcorta, D.A., Li, H., Yamamoto, T., Saito, Y., Nakamura, M. J. Biol. Chem. (2004) [Pubmed]
  16. Renal nerves modulate renin gene expression in the developing rat kidney with ureteral obstruction. el-Dahr, S.S., Gomez, R.A., Gray, M.S., Peach, M.J., Carey, R.M., Chevalier, R.L. J. Clin. Invest. (1991) [Pubmed]
  17. Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Yang, J., Dai, C., Liu, Y. Gene Ther. (2001) [Pubmed]
  18. Autoradiographic analysis and regulation of angiotensin receptor subtypes AT(4), AT(1), and AT((1-7)) in the kidney. Handa, R.K., Handa, S.E., Elgemark, M.K. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  19. Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. Norwood, V.F., Carey, R.M., Geary, K.M., Jose, P.A., Gomez, R.A., Chevalier, R.L. Kidney Int. (1994) [Pubmed]
  20. Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction. Li, C., Wang, W., Kwon, T.H., Knepper, M.A., Nielsen, S., Frøkiaer, J. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  21. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. Nguyen, H.T., Bride, S.H., Badawy, A.B., Adam, R.M., Lin, J., Orsola, A., Guthrie, P.D., Freeman, M.R., Peters, C.A. Am. J. Pathol. (2000) [Pubmed]
  22. Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1. Kawashima, H., Watanabe, N., Hirose, M., Sun, X., Atarashi, K., Kimura, T., Shikata, K., Matsuda, M., Ogawa, D., Heljasvaara, R., Rehn, M., Pihlajaniemi, T., Miyasaka, M. J. Biol. Chem. (2003) [Pubmed]
  23. Transforming growth factor-beta induces renal epithelial jagged-1 expression in fibrotic disease. Morrissey, J., Guo, G., Moridaira, K., Fitzgerald, M., McCracken, R., Tolley, T., Klahr, S. J. Am. Soc. Nephrol. (2002) [Pubmed]
  24. Renal function after release of ureteral obstruction: role of endothelin and the renal artery endothelium. Reyes, A.A., Klahr, S. Kidney Int. (1992) [Pubmed]
  25. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Kitagawa, K., Wada, T., Furuichi, K., Hashimoto, H., Ishiwata, Y., Asano, M., Takeya, M., Kuziel, W.A., Matsushima, K., Mukaida, N., Yokoyama, H. Am. J. Pathol. (2004) [Pubmed]
  26. Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction. Yang, J., Dai, C., Liu, Y. Am. J. Pathol. (2003) [Pubmed]
  27. Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Schaefer, L., Macakova, K., Raslik, I., Micegova, M., Gröne, H.J., Schönherr, E., Robenek, H., Echtermeyer, F.G., Grässel, S., Bruckner, P., Schaefer, R.M., Iozzo, R.V., Kresse, H. Am. J. Pathol. (2002) [Pubmed]
  28. Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy. Zhang, G., Kim, H., Cai, X., López-Guisa, J.M., Alpers, C.E., Liu, Y., Carmeliet, P., Eddy, A.A. J. Am. Soc. Nephrol. (2003) [Pubmed]
  29. Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis. Wada, T., Furuichi, K., Sakai, N., Iwata, Y., Kitagawa, K., Ishida, Y., Kondo, T., Hashimoto, H., Ishiwata, Y., Mukaida, N., Tomosugi, N., Matsushima, K., Egashira, K., Yokoyama, H. J. Am. Soc. Nephrol. (2004) [Pubmed]
  30. Deep nephron function after release of acute unilateral ureteral obstruction in the young rat. Buerkert, J., Martin, D., Head, M., Prasad, J., Klahr, S. J. Clin. Invest. (1978) [Pubmed]
  31. Myofibroblasts in experimental hydronephrosis. Diamond, J.R., van Goor, H., Ding, G., Engelmyer, E. Am. J. Pathol. (1995) [Pubmed]
  32. Azathioprine. An alternative treatment for recurrent idiopathic retroperitoneal fibrosis. Cogan, E., Fastrez, R. Arch. Intern. Med. (1985) [Pubmed]
  33. Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney. Hilgers, K.F., Nagaraj, S.K., Karginova, E.A., Kazakova, I.G., Chevalier, R.L., Carey, R.M., Pentz, E.S., Gomez, R.A. Kidney Int. (1998) [Pubmed]
  34. Immunization against retrograde pyelonephritis. III. Vaccination against chronic pyelonephritis due to Escherichia coli. Brooks, S.J., Lyons, J.M., Braude, A.I. J. Infect. Dis. (1977) [Pubmed]
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