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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Streptococcal M protein: a multipotent and powerful inducer of inflammation.

Severe infections with Streptococcus pyogenes, an important human pathogen, are associated with massive inflammatory reactions in the human host. Here we show that streptococcal M protein interacts with TLR2 on human peripheral blood monocytes. As a consequence, monocytes express the cytokines IL-6, IL-1beta, and TNF-alpha. This response is significantly increased in the presence of neutrophil-derived heparin-binding protein ( HBP), which co-stimulates monocytes by interacting with CD11/ CD18. Analysis of tissue biopsies from patients with necrotizing fasciitis revealed recruitment of neutrophils and monocytes to the infectious site, combined with the release of HBP. The results show that M protein, in synergy with HBP, evokes an inflammatory response that may contribute to the profound pathophysiological consequences seen in severe streptococcal infections.[1]

References

  1. Streptococcal M protein: a multipotent and powerful inducer of inflammation. Påhlman, L.I., Mörgelin, M., Eckert, J., Johansson, L., Russell, W., Riesbeck, K., Soehnlein, O., Lindbom, L., Norrby-Teglund, A., Schumann, R.R., Björck, L., Herwald, H. J. Immunol. (2006) [Pubmed]
 
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