Disease relevance of Fasciitis, Necrotizing

• We conclude that the group A streptococcal hyaluronic acid capsule and M protein, but not the cysteine protease, are critical for the development of tissue necrosis, secondary bacteremia, and lethal infection in a murine model of human necrotizing fasciitis [1].
• We have determined the crystal structure of streptococcal pyrogenic exotoxin B (SpeB), a cysteine protease that is a major virulence factor of the human pathogen Streptococcus pyogenes and participates in invasive disease episodes, including necrotizing fasciitis [2].
• Coagulation and fibrinolytic systems during the course of erysipelas and necrotizing fasciitis and the effect of heparin [3].
• Recurrent soft tissue infection in a patient with previous MRSA-related necrotizing fasciitis should therefore be treated with a high index of suspicion [4].
• Staphylococcus aureus has been a very uncommon cause of necrotizing fasciitis, but we have recently noted an alarming number of these infections caused by community-associated methicillin-resistant S. aureus (MRSA) [5].

High impact information on Fasciitis, Necrotizing

• Recurrent necrotizing fasciitis in complement C4 deficiency [6].
• Progression of group A streptococcal necrotizing fasciitis during moxalactam therapy [7].
• Two cases of necrotizing fasciitis in intravenous cocaine abusers are presented to alert the medical community to the possibility of these severe infections in such addicts [8].
• We report a case of necrotizing fasciitis associated with methylphenidate abuse from which H aphrophilus was isolated [9].
• IL-8-cleaving activity was found in partially purified supernatant of a necrotizing fasciitis isolate, and this activity was associated with an approximately 150-kDa fraction containing S. pyogenes cell envelope proteinase (SpyCEP) [10].

Chemical compound and disease context of Fasciitis, Necrotizing

• Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis [11].
• Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V. vulnificus in vitro, and this combination regimen can be a good choice as the empirical treatment for suspected necrotizing fasciitis due to V. vulnificus [12].
• Differential diagnosis between warfarin induced skin necrosis and necrotizing fasciitis, venous gangrene and other causes of skin necrosis may be difficult; the disease may also be confused with other dermatological entities [13].
• Diagnosis of group A streptococcal necrotizing fasciitis by using PCR to amplify the streptococcal pyrogenic exotoxin B gene [14].
• A case of heparin-induced cutaneous necrosis resembling necrotizing fasciitis occurred in a post-cesarean section patient [15].

Biological context of Fasciitis, Necrotizing

• Although it has been described following many surgical procedures, necrotizing fasciitis has not been previously described following postpartum tubal ligation [16].

Gene context of Fasciitis, Necrotizing

• In a murine model of streptococcal necrotizing fasciitis, the activated partial thromboplastin times were significantly prolonged in infected mice compared with controls, whereas prothrombin times were normal, suggesting an isolated abnormality of the intrinsic pathway [17].
• Two of the five patients who received PMN mobilized by G-CSF died of fungal infections or necrotizing fasciitis, although two of the remaining patients overcame severe bacterial infections [18].
• Necrotizing fasciitis in a patient with rheumatoid arthritis [19].
• Finally, we believe this to be the first reported case of diabetic ketoacidotic coma precipitated by necrotizing fasciitis [20].
• Systemic lupus erythematosus complicated by necrotizing fasciitis [21].

Analytical, diagnostic and therapeutic context of Fasciitis, Necrotizing

• In this article we present a case of fatal necrotizing fasciitis occurring in association with intramuscular injections of diclofenac in a patient who was admitted for the symptoms of a urinary stone [22].

References