Gene Review:
TLR2 - toll-like receptor 2
Homo sapiens
Synonyms:
CD282, TIL4, Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4
Netea,
Park,
Whitney,
von Beust,
Wüthrich,
Girardin,
Bot,
Drenth,
Jansen,
Mandell,
Van der Meer,
Ding,
Mitchell,
Naber,
Finberg,
Crowe,
Xinchun Chen,
Mingxia Zhang,
Xiuyun Zhu,
Qunyi Deng,
Haiying Liu,
Nicolas Larmonier,
Michael W. Graner,
Boping Zhou,
Johansen,
Ferwerda,
Smith,
Li,
Kramer,
Newburger,
Gosselin,
Kim,
Martinez Gomez,
Chang,
Goldberg,
Padgett,
Ryan,
Storni,
Senti,
Jacobs,
Kurt-Jones,
Adema,
Fitzmaurice,
Kündig,
de Jong,
Kullberg,
- Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Werts, C., Tapping, R.I., Mathison, J.C., Chuang, T.H., Kravchenko, V., Saint Girons, I., Haake, D.A., Godowski, P.J., Hayashi, F., Ozinsky, A., Underhill, D.M., Kirschning, C.J., Wagner, H., Aderem, A., Tobias, P.S., Ulevitch, R.J. Nat. Immunol. (2001)
- Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. Meng, G., Rutz, M., Schiemann, M., Metzger, J., Grabiec, A., Schwandner, R., Luppa, P.B., Ebel, F., Busch, D.H., Bauer, S., Wagner, H., Kirschning, C.J. J. Clin. Invest. (2004)
- Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Romics, L., Dolganiuc, A., Kodys, K., Drechsler, Y., Oak, S., Velayudham, A., Mandrekar, P., Szabo, G. Hepatology (2004)
- Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E.H., Lockett, S., Dunlop, N.M., Wang, J.M. J. Biol. Chem. (2006)
- Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2. Gaudreault, E., Fiola, S., Olivier, M., Gosselin, J. J. Virol. (2007)
- TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. Shigeoka, A.A., Holscher, T.D., King, A.J., Hall, F.W., Kiosses, W.B., Tobias, P.S., Mackman, N., McKay, D.B. J. Immunol. (2007)
- Toll-like receptor 2 variants are associated with acute reactive arthritis. Tsui, F.W., Xi, N., Rohekar, S., Riarh, R., Bilotta, R., Tsui, H.W., Inman, R.D. Arthritis Rheum. (2008)
- Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. Chen, X., Zhang, M., Zhu, X., Deng, Q., Liu, H., Larmonier, N., Graner, M.W., Zhou, B. J. Infect. Dis. (2009)
- Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Aliprantis, A.O., Yang, R.B., Mark, M.R., Suggett, S., Devaux, B., Radolf, J.D., Klimpel, G.R., Godowski, P., Zychlinsky, A. Science (1999)
- Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Krutzik, S.R., Ochoa, M.T., Sieling, P.A., Uematsu, S., Ng, Y.W., Legaspi, A., Liu, P.T., Cole, S.T., Godowski, P.J., Maeda, Y., Sarno, E.N., Norgard, M.V., Brennan, P.J., Akira, S., Rea, T.H., Modlin, R.L. Nat. Med. (2003)
- Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Lemjabbar, H., Basbaum, C. Nat. Med. (2002)
- Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J.L., Tong, L. Nature (2000)
- The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Underhill, D.M., Ozinsky, A., Hajjar, A.M., Stevens, A., Wilson, C.B., Bassetti, M., Aderem, A. Nature (1999)
- Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Yang, R.B., Mark, M.R., Gray, A., Huang, A., Xie, M.H., Zhang, M., Goddard, A., Wood, W.I., Gurney, A.L., Godowski, P.J. Nature (1998)
- Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Kurt-Jones, E.A., Mandell, L., Whitney, C., Padgett, A., Gosselin, K., Newburger, P.E., Finberg, R.W. Blood (2002)
- Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. Hajjar, A.M., O'Mahony, D.S., Ozinsky, A., Underhill, D.M., Aderem, A., Klebanoff, S.J., Wilson, C.B. J. Immunol. (2001)
- Toll-like receptor signaling in anti-cancer immunity. Okamoto, M., Sato, M. J. Med. Invest. (2003)
- Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy. De Rycke, L., Vandooren, B., Kruithof, E., De Keyser, F., Veys, E.M., Baeten, D. Arthritis Rheum. (2005)
- Upregulation of toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-kappa b activation. Liu, Y., Wang, Y., Yamakuchi, M., Isowaki, S., Nagata, E., Kanmura, Y., Kitajima, I., Maruyama, I. Infect. Immun. (2001)
- Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression. Hermoso, M.A., Matsuguchi, T., Smoak, K., Cidlowski, J.A. Mol. Cell. Biol. (2004)
- Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. Sabroe, I., Prince, L.R., Jones, E.C., Horsburgh, M.J., Foster, S.J., Vogel, S.N., Dower, S.K., Whyte, M.K. J. Immunol. (2003)
- Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. Kim, J., Ochoa, M.T., Krutzik, S.R., Takeuchi, O., Uematsu, S., Legaspi, A.J., Brightbill, H.D., Holland, D., Cunliffe, W.J., Akira, S., Sieling, P.A., Godowski, P.J., Modlin, R.L. J. Immunol. (2002)
- The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7. Yoshida, H., Jono, H., Kai, H., Li, J.D. J. Biol. Chem. (2005)
- Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. Smith, M.F., Mitchell, A., Li, G., Ding, S., Fitzmaurice, A.M., Ryan, K., Crowe, S., Goldberg, J.B. J. Biol. Chem. (2003)
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Dolganiuc, A., Oak, S., Kodys, K., Golenbock, D.T., Finberg, R.W., Kurt-Jones, E., Szabo, G. Gastroenterology (2004)
- Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Hausmann, M., Kiessling, S., Mestermann, S., Webb, G., Spöttl, T., Andus, T., Schölmerich, J., Herfarth, H., Ray, K., Falk, W., Rogler, G. Gastroenterology (2002)
- A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence. Sing, A., Reithmeier-Rost, D., Granfors, K., Hill, J., Roggenkamp, A., Heesemann, J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Pinhal-Enfield, G., Ramanathan, M., Hasko, G., Vogel, S.N., Salzman, A.L., Boons, G.J., Leibovich, S.J. Am. J. Pathol. (2003)
- Selective impairment of Toll-like receptor 2-mediated proinflammatory cytokine production by monocytes from patients with atopic dermatitis. Hasannejad, H., Takahashi, R., Kimishima, M., Hayakawa, K., Shiohara, T. J. Allergy Clin. Immunol. (2007)
- Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R.L., Akira, S. J. Immunol. (2002)
- Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae. Lazou Ahrén, I., Bjartell, A., Egesten, A., Riesbeck, K. J. Infect. Dis. (2001)
- Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. Netea, M.G., Ferwerda, G., de Jong, D.J., Jansen, T., Jacobs, L., Kramer, M., Naber, T.H., Drenth, J.P., Girardin, S.E., Kullberg, B.J., Adema, G.J., Van der Meer, J.W. J. Immunol. (2005)
- Toll-like receptor ligands as adjuvants in allergen-specific immunotherapy. Johansen, P., Senti, G., Martinez Gomez, J.M., Storni, T., von Beust, B.R., Wüthrich, B., Bot, A., Kündig, T.M. Clin. Exp. Allergy (2005)
- TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. Oak, S., Mandrekar, P., Catalano, D., Kodys, K., Szabo, G. J. Immunol. (2006)
- Apoptosis signal-regulating kinase 1-mediated sustained p38 mitogen-activated protein kinase activation regulates mycoplasmal lipoprotein- and staphylococcal peptidoglycan-triggered Toll-like receptor 2 signalling pathways. Into, T., Shibata, K. Cell. Microbiol. (2005)
- Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. Nakao, Y., Funami, K., Kikkawa, S., Taniguchi, M., Nishiguchi, M., Fukumori, Y., Seya, T., Matsumoto, M. J. Immunol. (2005)
- Pneumococcal lipoteichoic acid (LTA) is not as potent as staphylococcal LTA in stimulating Toll-like receptor 2. Han, S.H., Kim, J.H., Martin, M., Michalek, S.M., Nahm, M.H. Infect. Immun. (2003)
- Human monocytoid cells as a model to study Toll-like receptor-mediated activation. Remer, K.A., Brcic, M., Sauter, K.S., Jungi, T.W. J. Immunol. Methods (2006)
- Dependence on p38 MAPK signalling in the up-regulation of TLR2, TLR4 and TLR9 gene expression in Trichomonas vaginalis-treated HeLa cells. Chang, J.H., Park, J.Y., Kim, S.K. Immunology (2006)
- Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. Kirschning, C.J., Wesche, H., Merrill Ayres, T., Rothe, M. J. Exp. Med. (1998)
- Human Langerhans Cells Express a Specific TLR Profile and Differentially Respond to Viruses and Gram-Positive Bacteria. Flacher, V., Bouschbacher, M., Verron??se, E., Massacrier, C., Sisirak, V., Berthier-Vergnes, O., de Saint-Vis, B., Caux, C., Dezutter-Dambuyant, C., Lebecque, S., Valladeau, J. J. Immunol. (2006)
- Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Aslam, R., Speck, E.R., Kim, M., Crow, A.R., Bang, K.W., Nestel, F.P., Ni, H., Lazarus, A.H., Freedman, J., Semple, J.W. Blood (2006)
- Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. Melmed, G., Thomas, L.S., Lee, N., Tesfay, S.Y., Lukasek, K., Michelsen, K.S., Zhou, Y., Hu, B., Arditi, M., Abreu, M.T. J. Immunol. (2003)
- Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., Kirschning, C.J. J. Biol. Chem. (1999)
- Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Seibl, R., Birchler, T., Loeliger, S., Hossle, J.P., Gay, R.E., Saurenmann, T., Michel, B.A., Seger, R.A., Gay, S., Lauener, R.P. Am. J. Pathol. (2003)