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MeSH Review

Streptococcal Infections

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Disease relevance of Streptococcal Infections


High impact information on Streptococcal Infections


Chemical compound and disease context of Streptococcal Infections

  • The efficacy of a single dose of aqueous penicillin G in preventing neonatal group-B streptococcal infections was demonstrated in a randomised study conducted over 41 months [9].
  • A significant activation of the complement common pathway (from C3 to terminal components) was observed only with SK infusion and is attributable to the rapid formation of immunocomplexes between SK and anti-SK antibodies present in plasma as a consequence of previous streptococcal infections [10].
  • RESULTS: Significant decreases in streptococcal infections during the study year were found with a mean of .1 (.3 SD) per subject, compared to the baseline year with 1.9 (1.2 SD) in the penicillin group and 2.4 (1.1 SD) in the azithromycin group [p<.01] [11].
  • CONCLUSIONS: Penicillin and azithromycin prophylaxis were found to be effective in decreasing streptococcal infections and neuropsychiatric symptom exacerbations among children in the PANDAS subgroup [11].
  • Because of the poor activities of erythromycin and azithromycin against S. pyogenes isolates from patients in southern Taiwan, these drugs should no longer be considered the drugs of choice for the management of group A streptococcal infections among patients who live in this area [12].

Biological context of Streptococcal Infections


Anatomical context of Streptococcal Infections


Gene context of Streptococcal Infections


Analytical, diagnostic and therapeutic context of Streptococcal Infections


  1. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Herwald, H., Cramer, H., Mörgelin, M., Russell, W., Sollenberg, U., Norrby-Teglund, A., Flodgaard, H., Lindbom, L., Björck, L. Cell (2004) [Pubmed]
  2. Prophylaxis of streptococcal infections and rheumatic fever: a comparison of orally administered clindamycin and penicillin. Massell, B.F. JAMA (1979) [Pubmed]
  3. Antibodies to streptococcal surface enolase react with human alpha-enolase: implications in poststreptococcal sequelae. Fontán, P.A., Pancholi, V., Nociari, M.M., Fischetti, V.A. J. Infect. Dis. (2000) [Pubmed]
  4. Immunoglobulins to group A streptococcal surface molecules decrease adherence to and invasion of human pharyngeal cells. Fluckiger, U., Jones, K.F., Fischetti, V.A. Infect. Immun. (1998) [Pubmed]
  5. Post-streptococcal autoimmune disorders of the central nervous system. Snider, L.A., Swedo, S.E. Curr. Opin. Neurol. (2003) [Pubmed]
  6. Response to type III polysaccharide in women whose infants have had invasive group B streptococcal infection. Baker, C.J., Rench, M.A., Kasper, D.L. N. Engl. J. Med. (1990) [Pubmed]
  7. The changing epidemiology of invasive group A streptococcal infections and the emergence of streptococcal toxic shock-like syndrome. A retrospective population-based study. Hoge, C.W., Schwartz, B., Talkington, D.F., Breiman, R.F., MacNeill, E.M., Englender, S.J. JAMA (1993) [Pubmed]
  8. Regulation of the phosphorylation of human pharyngeal cell proteins by group A streptococcal surface dehydrogenase: signal transduction between streptococci and pharyngeal cells. Pancholi, V., Fischetti, V.A. J. Exp. Med. (1997) [Pubmed]
  9. Single-dose penicillin prophylaxis of neonatal group-B-streptococcal disease. Siegel, J.D., McCracken, G.H., Threlkeld, N., DePasse, B.M., Rosenfeld, C.R. Lancet (1982) [Pubmed]
  10. Activation of complement and kinin systems after thrombolytic therapy in patients with acute myocardial infarction. A comparison between streptokinase and recombinant tissue-type plasminogen activator. Agostoni, A., Gardinali, M., Frangi, D., Cafaro, C., Conciato, L., Sponzilli, C., Salvioni, A., Cugno, M., Cicardi, M. Circulation (1994) [Pubmed]
  11. Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Snider, L.A., Lougee, L., Slattery, M., Grant, P., Swedo, S.E. Biol. Psychiatry (2005) [Pubmed]
  12. Decreased activity of erythromycin against Streptococcus pyogenes in Taiwan. Hsueh, P.R., Chen, H.M., Huang, A.H., Wu, J.J. Antimicrob. Agents Chemother. (1995) [Pubmed]
  13. Contribution of protein G-related alpha2-macroglobulin-binding protein to bacterial virulence in a mouse skin model of group A streptococcal infection. Toppel, A.W., Rasmussen, M., Rohde, M., Medina, E., Chhatwal, G.S. J. Infect. Dis. (2003) [Pubmed]
  14. Inhibition of streptokinase-induced, antibody-mediated platelet aggregation with tirofiban after exposure to streptokinase or streptococcal infection. Courval, M., Palisaitis, D.A., Diodati, J.G., Lesperance, B., Pharand, C. Pharmacotherapy (2004) [Pubmed]
  15. Increased pulmonary susceptibility to streptococcal infection following inhalation of manganese oxide. Adkins, B., Luginbuhl, G.H., Miller, F.J., Gardner, D.E. Environmental research. (1980) [Pubmed]
  16. The anti-MAP and anti-group A carbohydrate antibodies response in streptococcal human infections. Mihalcu, F., Stefãnescu, M. Dev. Biol. Stand. (1975) [Pubmed]
  17. Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit/hyperactivity disorders. Peterson, B.S., Leckman, J.F., Tucker, D., Scahill, L., Staib, L., Zhang, H., King, R., Cohen, D.J., Gore, J.C., Lombroso, P. Arch. Gen. Psychiatry (2000) [Pubmed]
  18. A role for C5 and C5a-ase in the acute neutrophil response to group B streptococcal infections. Bohnsack, J.F., Widjaja, K., Ghazizadeh, S., Rubens, C.E., Hillyard, D.R., Parker, C.J., Albertine, K.H., Hill, H.R. J. Infect. Dis. (1997) [Pubmed]
  19. Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope. Olive, C., Clair, T., Yarwood, P., Good, M.F. Vaccine (2002) [Pubmed]
  20. Myocardial infarction associated with pseudoephedrine use and acute streptococcal infection in a boy with normal coronary arteries. Biyik, I., Ergene, O. The Canadian journal of cardiology. (2006) [Pubmed]
  21. Occurrence and specificity of antibodies against group-specific polysaccharides in beta-hemolytic streptococcal infections. Seppälä, I.J., Larinkari, U., Räsänen, T., Valtonen, V.V. Acta pathologica et microbiologica Scandinavica. Section B, Microbiology. (1981) [Pubmed]
  22. Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection. Teti, G., Mancuso, G., Tomasello, F. Infect. Immun. (1993) [Pubmed]
  23. Correlation between serum TNF alpha and IL6 levels and severity of group A streptococcal infections. Norrby-Teglund, A., Pauksens, K., Norgren, M., Holm, S.E. Scand. J. Infect. Dis. (1995) [Pubmed]
  24. Soluble adhesion molecules in Gilles de la Tourette's syndrome. Martino, D., Church, A.J., Defazio, G., Dale, R.C., Quinn, N.P., Robertson, M.M., Livrea, P., Orth, M., Giovannoni, G. J. Neurol. Sci. (2005) [Pubmed]
  25. Streptokinase promotes development of dipeptidyl peptidase IV (CD26) autoantibodies after fibrinolytic therapy in myocardial infarction patients. Cuchacovich, M., Gatica, H., Vial, P., Yovanovich, J., Pizzo, S.V., Gonzalez-Gronow, M. Clin. Diagn. Lab. Immunol. (2002) [Pubmed]
  26. Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Wessels, M.R., Butko, P., Ma, M., Warren, H.B., Lage, A.L., Carroll, M.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. High-dose intravenous immune globulin impairs antibacterial activity of antibiotics. Kim, K.S. J. Allergy Clin. Immunol. (1989) [Pubmed]
  28. Type-specific protection of neonatal rats from lethal group B streptococcal infection by immune sera obtained from human volunteers vaccinated with type III-specific polysaccharide. De Cueninck, B.J., Eisenstein, T.K., McIntosh, T.S., Shockman, G.D., Swenson, R.M. Infect. Immun. (1982) [Pubmed]
  29. Effect of fibronectin on IgA-mediated uptake of type III group B streptococci by phagocytes. Yang, K.D., Bohnsack, J.F., Hawley, M.M., Augustine, N.H., Knape, W.A., Egan, M.L., Pritchard, D.G., Hill, H.R. J. Infect. Dis. (1990) [Pubmed]
  30. Evaluation of a commercially available latex agglutination test for rapid diagnosis of group B streptococcal infection. Rabalais, G.P., Bronfin, D.R., Daum, R.S. Pediatr. Infect. Dis. J. (1987) [Pubmed]
  31. Streptococcal pharyngitis in Italian children: epidemiology and treatment with miocamycin. Principi, N., Marchisio, P., Calanchi, A., Onorato, J., Plebani, A., Reali, E., Rancilio, L., Grasso, E., Magni, L., Caramia, G. Drugs under experimental and clinical research. (1990) [Pubmed]
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