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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Growth-factor independence of a new differentiated hepatitis B virus DNA-negative human hepatoma cell line.

The establishment of a new, differentiated, hepatitis B virus DNA-negative, human hepatoma cell line (named PLC/AN/2) is described. Neoplastic liver tissue was obtained during hepatectomy in an HBsAg-negative man. The established cell line is negative for alpha-fetoprotein and carcinoembryonic antigen; it has retained in vitro some of the differentiated functions of normal hepatocytes. Additionally, it presents a distinctive rearrangement ( translocation) at the long arm of chromosome 4. The high degree of independence from serum growth factor requirements appears to be a major in vitro characteristic of PLC/AN/2 cells, making them a suitable model system for the more precise definition of the human hepatocellular carcinoma phenotype, including mechanisms of growth control.[1]

References

  1. Growth-factor independence of a new differentiated hepatitis B virus DNA-negative human hepatoma cell line. Bagnarelli, P., Devescovi, G., Manzin, A., Bearzi, I., Bonazzi, P., Carloni, G., Clementi, M. Hepatology (1990) [Pubmed]
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