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Gene Review

CEACAM5  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CD66e, CEA, Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, Meconium antigen 100
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Disease relevance of CEACAM5


Psychiatry related information on CEACAM5


High impact information on CEACAM5


Chemical compound and disease context of CEACAM5


Biological context of CEACAM5


Anatomical context of CEACAM5


Associations of CEACAM5 with chemical compounds


Physical interactions of CEACAM5


Regulatory relationships of CEACAM5


Other interactions of CEACAM5


Analytical, diagnostic and therapeutic context of CEACAM5


  1. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Blumenthal, R.D., Hansen, H.J., Goldenberg, D.M. Cancer Res. (2005) [Pubmed]
  2. A phase I trial combining high-dose 90Y-labeled humanized anti-CEA monoclonal antibody with doxorubicin and peripheral blood stem cell rescue in advanced medullary thyroid cancer. Sharkey, R.M., Hajjar, G., Yeldell, D., Brenner, A., Burton, J., Rubin, A., Goldenberg, D.M. J. Nucl. Med. (2005) [Pubmed]
  3. Immunobead multiplex RT-PCR detection of carcinoembryonic genes expressing cells in the blood of colorectal cancer patients. Douard, R., Moutereau, S., Serru, V., Sales, J.P., Wind, P., Cugnenc, P.H., Vaubourdolle, M., Loric, S. Clin. Chem. Lab. Med. (2005) [Pubmed]
  4. Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Liebig, B., Brabletz, T., Staege, M.S., Wulfänger, J., Riemann, D., Burdach, S., Ballhausen, W.G. Cancer Lett. (2005) [Pubmed]
  5. The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Baczyńska, D., Wietrzyk, J., Madej, J., Krop-Watorek, A., Dabrowska, A., Widerak, K., Opolski, A., Ugorski, M. Cell. Mol. Biol. Lett. (2003) [Pubmed]
  6. Anti-idiotype antibody induced cellular immunity in mice transgenic for human carcinoembryonic antigen. Saha, A., Chatterjee, S.K., Foon, K.A., Bhattacharya-Chatterjee, M. Immunology (2006) [Pubmed]
  7. Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer. Krimmel, M., Hoffmann, J., Krimmel, C., Cornelius, C.P., Schwenzer, N. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (1998) [Pubmed]
  8. The usefulness of carcinoembryonic antigen testing in the overall management of patients with non-small-cell lung cancer. Sadoff, L. Am. J. Clin. Oncol. (1998) [Pubmed]
  9. T-lymphocyte control of HLA-DR blood monocyte differentiation into neo-fibroblasts. Further evidence of pluripotential secreting functions of HLA-DR monocytes, involving not only collagen but also uromodulin, amyloid-beta peptide, alpha-fetoprotein and carcinoembryonic antigen. Bringuier, A.F., Séébold-Choqueux, C., Moricard, Y., Simmons, D.J., Milhaud, G., Labat, M.L. Biomed. Pharmacother. (1992) [Pubmed]
  10. The use of cancer registry data to study preoperative carcinoembryonic antigen level as an indicator of survival in colorectal cancer. Sener, S.F., Imperato, J.P., Chmiel, J., Fremgen, A., Sylvester, J. CA: a cancer journal for clinicians. (1989) [Pubmed]
  11. Detection of carcinoembryonic antigen messenger RNA in lymph nodes from patients with colorectal cancer. Bostick, P.J., Hoon, D.S., Cote, R.J. N. Engl. J. Med. (1998) [Pubmed]
  12. Micrometastases and survival in stage II colorectal cancer. Liefers, G.J., Cleton-Jansen, A.M., van de Velde, C.J., Hermans, J., van Krieken, J.H., Cornelisse, C.J., Tollenaar, R.A. N. Engl. J. Med. (1998) [Pubmed]
  13. Carcinoembryonic antigen as a tissue marker in medullary thyroid carcinoma. DeLellis, R.A., Wolfe, H.J., Rule, A.H. N. Engl. J. Med. (1978) [Pubmed]
  14. Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. Ransohoff, D.F., Feinstein, A.R. N. Engl. J. Med. (1978) [Pubmed]
  15. The 95-kilodalton membrane glycoprotein overexpressed in novel multidrug-resistant breast cancer cells is NCA, the nonspecific cross-reacting antigen of carcinoembryonic antigen. Ross, D.D., Gao, Y., Yang, W., Leszyk, J., Shively, J., Doyle, L.A. Cancer Res. (1997) [Pubmed]
  16. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Duxbury, M.S., Ito, H., Benoit, E., Waseem, T., Ashley, S.W., Whang, E.E. Cancer Res. (2004) [Pubmed]
  17. Binding of Escherichia coli and Salmonella strains to members of the carcinoembryonic antigen family: differential binding inhibition by aromatic alpha-glycosides of mannose. Leusch, H.G., Drzeniek, Z., Markos-Pusztai, Z., Wagener, C. Infect. Immun. (1991) [Pubmed]
  18. Antiserum to carcinoembryonic antigen recognizes a phosphotyrosine-containing protein in human colon cancer cell lines. Skubitz, K.M., Ducker, T.P., Skubitz, A.P., Goueli, S.A. FEBS Lett. (1993) [Pubmed]
  19. Prospects of radioimmunotherapy in epithelial ovarian cancer: results with iodine-131-labeled murine and humanized MN-14 anti-carcinoembryonic antigen monoclonal antibodies. Juweid, M., Swayne, L.C., Sharkey, R.M., Dunn, R., Rubin, A.D., Herskovic, T., Goldenberg, D.M. Gynecol. Oncol. (1997) [Pubmed]
  20. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo. Horst, A.K., Ito, W.D., Dabelstein, J., Schumacher, U., Sander, H., Turbide, C., Brümmer, J., Meinertz, T., Beauchemin, N., Wagener, C. J. Clin. Invest. (2006) [Pubmed]
  21. Isolation and characterization of the normal crossreacting antigen: homology of its NH2-terminal amino acid sequence with that of carcinoembryonic antigen. Engvall, E., Shively, J.E., Wrann, M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  22. Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family. Paxton, R.J., Mooser, G., Pande, H., Lee, T.D., Shively, J.E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  23. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. Thompson, J., Seitz, M., Chastre, E., Ditter, M., Aldrian, C., Gespach, C., Zimmermann, W. Cancer Res. (1997) [Pubmed]
  24. Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors. McCaw, S.E., Liao, E.H., Gray-Owen, S.D. Infect. Immun. (2004) [Pubmed]
  25. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. Eidelman, F.J., Fuks, A., DeMarte, L., Taheri, M., Stanners, C.P. J. Cell Biol. (1993) [Pubmed]
  26. Expression of carcinoembryonic antigen and nonspecific cross-reacting 50-kDa antigen in human normal and cancerous colon mucosa: comparative ultrastructural study with monoclonal antibodies. Baranov, V., Yeung, M.M., Hammarström, S. Cancer Res. (1994) [Pubmed]
  27. Therapy of established tumors in a novel murine model transgenic for human carcinoembryonic antigen and HLA-A2 with a combination of anti-idiotype vaccine and CTL peptides of carcinoembryonic antigen. Saha, A., Chatterjee, S.K., Foon, K.A., Celis, E., Bhattacharya-Chatterjee, M. Cancer Res. (2007) [Pubmed]
  28. Molecular cloning and expression of cDNA for a carcinoembryonic antigen-related fetal liver glycoprotein. Khan, W.N., Osterman, A., Hammarström, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Carcinoembryonic antigen-related cell adhesion molecule 1 is the 85-kilodalton pronase-resistant biliary glycoprotein in the cholesterol crystallization promoting low density protein-lipid complex. Jirsa, M., Muchová, L., Dráberová, L., Dráber, P., Smíd, F., Kuroki, M., Marecek, Z., Groen, A.K. Hepatology (2001) [Pubmed]
  30. Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: determination of affinities and specificities of monoclonal antibodies by using biotin-labeled antibodies and avidin as precipitating agent in a solution phase immunoassay. Wagener, C., Clark, B.R., Rickard, K.J., Shively, J.E. J. Immunol. (1983) [Pubmed]
  31. GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction&. Ordonez, C., Zhai, A.B., Camacho-Leal, P., Demarte, L., Fan, M.M., Stanners, C.P. J. Cell. Physiol. (2007) [Pubmed]
  32. Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells. Guignot, J., Peiffer, I., Bernet-Camard, M.F., Lublin, D.M., Carnoy, C., Moseley, S.L., Servin, A.L. Infect. Immun. (2000) [Pubmed]
  33. Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells. Ideo, H., Seko, A., Yamashita, K. J. Biol. Chem. (2005) [Pubmed]
  34. Carcinoembryonic antigen and lectin binding in the bile canalicular structures of hepatocellular carcinoma. Machinami, R., Oono, Y. Virchows Archiv. A, Pathological anatomy and histopathology. (1987) [Pubmed]
  35. Recognition by TNF-alpha of the GPI-anchor glycan induces apoptosis of U937 cells. Fukushima, K., Ishiyama, C., Yamashita, K. Arch. Biochem. Biophys. (2004) [Pubmed]
  36. Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. Blumenthal, R.D., Leon, E., Hansen, H.J., Goldenberg, D.M. BMC Cancer (2007) [Pubmed]
  37. CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. Kuijpers, T.W., Hoogerwerf, M., van der Laan, L.J., Nagel, G., van der Schoot, C.E., Grunert, F., Roos, D. J. Cell Biol. (1992) [Pubmed]
  38. Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells. Jay, P., Berta, P., Blache, P. Cancer Res. (2005) [Pubmed]
  39. P53-immunoreactive cells in benign and malignant effusions: diagnostic value using a panel of monoclonal antibodies and comparison with CEA-staining. Stoetzer, O.J., Munker, R., Darsow, M., Wilmanns, W. Oncol. Rep. (1999) [Pubmed]
  40. Comparison of glycoprotein expression between ovarian and colon adenocarcinomas. Multhaupt, H.A., Arenas-Elliott, C.P., Warhol, M.J. Arch. Pathol. Lab. Med. (1999) [Pubmed]
  41. Corticotropin-releasing hormone modulates human trophoblast invasion through carcinoembryonic antigen-related cell adhesion molecule-1 regulation. Bamberger, A.M., Minas, V., Kalantaridou, S.N., Radde, J., Sadeghian, H., Löning, T., Charalampopoulos, I., Brümmer, J., Wagener, C., Bamberger, C.M., Schulte, H.M., Chrousos, G.P., Makrigiannakis, A. Am. J. Pathol. (2006) [Pubmed]
  42. Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer. Pollán, M., Varela, G., Torres, A., de la Torre, M., Ludeña, M.D., Ortega, M.D., Pac, J., Freixenet, J., Gómez, G., Sebastián, F., Díez, M., Arrabal, R., Canalís, E., García-Tirado, J., Arnedillo, A., Rivas, J.J., Minguella, J., Gómez, A., García, M., Aragonés, N., Pérez-Gómez, B., López-Abente, G., González-Sarmiento, R., Rojas, J.M. Int. J. Cancer (2003) [Pubmed]
  43. Differential expression of tumor-associated antigens in human colon carcinomas xenografted into nude mice. Gold, D.V., Shochat, D., Primus, F.J., Dexter, D.L., Calabresi, P., Goldenberg, D.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  44. Ablation of human colon carcinoma in nude mice by 131I-labeled monoclonal anti-carcinoembryonic antigen antibody F(ab')2 fragments. Buchegger, F., Pfister, C., Fournier, K., Prevel, F., Schreyer, M., Carrel, S., Mach, J.P. J. Clin. Invest. (1989) [Pubmed]
  45. A monoclonal antibody-enzyme immunoassay for serum carcinoembryonic antigen with increased specificity for carcinomas. Hedin, A., Carlsson, L., Berglund, A., Hammarström, S. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
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