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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits.

To study in detail the relation between gene expression and resistance against gemcitabine, a cell line was isolated from a tumor for which gemcitabine resistance was induced in vivo. Similar to the in vivo tumor, resistance in this cell line, C 26-G, was not related to deficiency of deoxycytidine kinase (dCK). Micro-array analysis showed increased expression of ribonucleotide reductase (RR) subunits M1 and M2 as confirmed by real time PCR analysis (28- and 2.7-fold, respectively). In cell culture, moderate cross-resistance (about 2-fold) was observed to 1-ss-D-arabinofuranosylcytosine (ara-C), 2-chloro-2'deoxyadenosine (CdA), LY231514 (ALIMTA), and cisplatin (CDDP), and pronounced cross-resistance (>23-fold) to 2',2'-difluorodeoxyuridine (dFdU) and 2',2'-difluorodeoxyguanosine (dFdG). Culture in the absence of gemcitabine reduced resistance as well as RRM1 RNA expression, demonstrating a direct relationship of RRM1 RNA expression with acquired resistance to gemcitabine.[1]

References

  1. Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Smid, K., Bergman, A.M., Eijk, P.P., Veerman, G., Ruiz van Haperen, V.W., van den Ijssel, P., Ylstra, B., Peters, G.J. Nucleosides Nucleotides Nucleic Acids (2006) [Pubmed]
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