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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Transepithelial Leak in Barrett's Esophagus.

Using orally administered sucrose as a probe of gastrointestinal permeability, this study focused on determining whether Barrett's metaplasia exhibits a paracellular transepithelial leak to small nonelectrolytes. Subjects in five separate classes (nonendoscoped, asymptomatic controls; endoscoped, asymptomatic controls; gastroesophageal reflux disease without mucosal complications; grossly visible esophagitis; and Barrett's esophagus) consumed a sucrose solution at bedtime and collected all overnight urine. Urine volume was measured and sucrose concentration was determined by high-performance liquid chromatography. Patients with Barrett's were observed to exhibit a transepithelial leak to sucrose whose mean value was threefold greater than that seen in healthy control subjects or patients with reflux but without any mucosal defect. A parallel study of claudin tight junction proteins in endoscopy biopsy samples showed that whereas Barrett's metaplasia contains dramatically more claudin-2 and claudin-3 than is found in normal esophageal mucosa, it is markedly lower in claudins 1 and 5, indicating very different tight junction barriers.[1]


  1. Transepithelial Leak in Barrett's Esophagus. Mullin, J.M., Valenzano, M.C., Trembeth, S., Allegretti, P.D., Verrecchio, J.J., Schmidt, J.D., Jain, V., Meddings, J.B., Mercogliano, G., Thornton, J.J. Dig. Dis. Sci. (2006) [Pubmed]
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