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Gene Review

CLDN3  -  claudin 3

Homo sapiens

Synonyms: C7orf1, CPE-R 2, CPE-R2, CPE-receptor 2, CPETR2, ...
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Disease relevance of CLDN3


High impact information on CLDN3


Chemical compound and disease context of CLDN3


Biological context of CLDN3


Anatomical context of CLDN3

  • RESULTS: We confirmed that these genes are highly overexpressed in all histological subtypes of EOC compared with normal ovarian surface epithelium, identifying DDR1 and CLDN3 as new biomarkers of EOC [10].
  • CONCLUSIONS: These results show that CLDN3 and CLDN4 are frequently up-regulated in ovarian tumors and cell lines and may represent novel markers for this disease [1].
  • While normal gastric mucosa lacked Claudin 3, 4, and 7 expression, intestinal metaplasia and dysplasia showed these proteins [14].
  • By microarray analysis, Claudin 3 showed a marked increase in mRNA expression compared with normal esophagus (approximately 100-fold) [14].
  • High levels of expression of CPE-R and/or RVP1 mRNA were also detected in other organs, including the lungs, liver, and kidneys, but only low levels were expressed in heart and skeletal muscles [15].

Associations of CLDN3 with chemical compounds


Other interactions of CLDN3


Analytical, diagnostic and therapeutic context of CLDN3


  1. Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Rangel, L.B., Agarwal, R., D'Souza, T., Pizer, E.S., Alò, P.L., Lancaster, W.D., Gregoire, L., Schwartz, D.R., Cho, K.R., Morin, P.J. Clin. Cancer Res. (2003) [Pubmed]
  2. Tight junctions and compression therapy in chronic venous insufficiency. Herouy, Y., Kahle, B., Idzko, M., Eberth, I., Norgauer, J., Pannier, F., Rabe, E., Jünger, M., Bruckner-Tuderman, L. Int. J. Mol. Med. (2006) [Pubmed]
  3. Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium. Long, H., Crean, C.D., Lee, W.H., Cummings, O.W., Gabig, T.G. Cancer Res. (2001) [Pubmed]
  4. Intraepithelial gammadelta(+) Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection. Dalton, J.E., Cruickshank, S.M., Egan, C.E., Mears, R., Newton, D.J., Andrew, E.M., Lawrence, B., Howell, G., Else, K.J., Gubbels, M.J., Striepen, B., Smith, J.E., White, S.J., Carding, S.R. Gastroenterology (2006) [Pubmed]
  5. Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. Grotegut, S., von Schweinitz, D., Christofori, G., Lehembre, F. EMBO J. (2006) [Pubmed]
  6. Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Agarwal, R., D'Souza, T., Morin, P.J. Cancer Res. (2005) [Pubmed]
  7. Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin. Santin, A.D., Cané, S., Bellone, S., Palmieri, M., Siegel, E.R., Thomas, M., Roman, J.J., Burnett, A., Cannon, M.J., Pecorelli, S. Cancer Res. (2005) [Pubmed]
  8. Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Morin, P.J. Cancer Res. (2005) [Pubmed]
  9. Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. D'Souza, T., Agarwal, R., Morin, P.J. J. Biol. Chem. (2005) [Pubmed]
  10. Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Heinzelmann-Schwarz, V.A., Gardiner-Garden, M., Henshall, S.M., Scurry, J., Scolyer, R.A., Davies, M.J., Heinzelmann, M., Kalish, L.H., Bali, A., Kench, J.G., Edwards, L.S., Vanden Bergh, P.M., Hacker, N.F., Sutherland, R.L., O'Brien, P.M. Clin. Cancer Res. (2004) [Pubmed]
  11. Identification of a transcriptional profile associated with in vitro invasion in non-small cell lung cancer cell lines. Lader, A.S., Ramoni, M.F., Zetter, B.R., Kohane, I.S., Kwiatkowski, D.J. Cancer Biol. Ther. (2004) [Pubmed]
  12. Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Zhu, Y., Brännström, M., Janson, P.O., Sundfeldt, K. Int. J. Cancer (2006) [Pubmed]
  13. Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Hough, C.D., Sherman-Baust, C.A., Pizer, E.S., Montz, F.J., Im, D.D., Rosenshein, N.B., Cho, K.R., Riggins, G.J., Morin, P.J. Cancer Res. (2000) [Pubmed]
  14. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Montgomery, E., Mamelak, A.J., Gibson, M., Maitra, A., Sheikh, S., Amr, S.S., Yang, S., Brock, M., Forastiere, A., Zhang, S., Murphy, K.M., Berg, K.D. Appl. Immunohistochem. Mol. Morphol. (2006) [Pubmed]
  15. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. Katahira, J., Sugiyama, H., Inoue, N., Horiguchi, Y., Matsuda, M., Sugimoto, N. J. Biol. Chem. (1997) [Pubmed]
  16. Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Tokés, A.M., Kulka, J., Paku, S., Szik, A., Páska, C., Novák, P.K., Szilák, L., Kiss, A., Bögi, K., Schaff, Z. Breast Cancer Res. (2005) [Pubmed]
  17. Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma. Soini, Y. Hum. Pathol. (2004) [Pubmed]
  18. PPARgamma-regulated tight junction development during human urothelial cytodifferentiation. Varley, C.L., Garthwaite, M.A., Cross, W., Hinley, J., Trejdosiewicz, L.K., Southgate, J. J. Cell. Physiol. (2006) [Pubmed]
  19. Claudin 5 is transiently expressed during the development of the retinal pigment epithelium. Kojima, S., Rahner, C., Peng, S., Rizzolo, L.J. J. Membr. Biol. (2002) [Pubmed]
  20. Identification of multiple claudins in the rat epididymis. Gregory, M., Cyr, D.G. Mol. Reprod. Dev. (2006) [Pubmed]
  21. Transepithelial Leak in Barrett's Esophagus. Mullin, J.M., Valenzano, M.C., Trembeth, S., Allegretti, P.D., Verrecchio, J.J., Schmidt, J.D., Jain, V., Meddings, J.B., Mercogliano, G., Thornton, J.J. Dig. Dis. Sci. (2006) [Pubmed]
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